Insulin’s Weighted Model 1984 transcripts’ weighted models overlap with insulin’s weighted model Ping Wang.

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Presentation transcript:

Insulin’s Weighted Model 1984 transcripts’ weighted models overlap with insulin’s weighted model Ping Wang

Insulin linkage via scanone Ping Wang

Insulin’s Model Plots Ping Wang How many islet transcripts show this same genetic dependence at these loci?

Modules for 1984 transcripts with similar genetic architecture as insulin contains the insulin trait Ping Wang

SetPvalueQvalueCountSizeTerm MF5.04E E cytoplasm MF7.41E E cytoplasmic part MF6.20E mitochondrion MF2.17E intracellular part MF4.27E intracellular BP biosynthetic process MF organelle CC oxidoreductase activity, acting on the CH-CH group of donors BP cellular lipid metabolic process Ping WangMapping by BIM

Ping Wang SetPvalueQvalueCountSizeTerm MF5.04E E cytoplasm MF7.41E E cytoplasmic part MF6.20E mitochondrion MF2.17E intracellular part MF4.27E intracellular BP biosynthetic process MF organelle CC oxidoreductase activity, acting on the CH-CH group of donors BP cellular lipid metabolic process Mapping by BIM

SetPvalueQvalueCountSizeTerm MF1.74E extracellular matrix part CC1.61E extracellular matrix structural constituent conferring tensile strength MF6.31E collagen MF proteinaceous extracellular matrix MF extracellular matrix CC extracellular matrix structural constituent BP phosphate transport Ping WangMapping by BIM

SetPvalueQvalueCountSizeTerm BP nucleobase, nucleoside, nucleotide and nucleic acid metabolic process MF intracellular organelle MF organelle MF cytoskeleton BP pyrimidine ribonucleotide metabolic process BP pyrimidine ribonucleotide biosynthetic process BP regulation of protein stability MF intracellular part BP transcription initiation from RNA polymerase II promoter Ping WangMapping by BIM

SetPvalueQvalueCountSizeTerm BP sensory perception of sound BP sensory perception of mechanical stimulus MF basement membrane Ping WangMapping by BIM

SetPvalueQvalueCountSizeTerm MF4.63E E-05563chromosome, pericentric region BP2.54E cell cycle process BP microtubule-based process BP mitotic cell cycle BP M phase BP cell division MF condensed chromosome, pericentric region MF non-membrane-bound organelle MF intracellular non-membrane-bound organelle MF intracellular organelle part MF organelle part MF chromosomal part Ping WangMapping by BIM

Ping WangMapping by BIM

SetPvalueQvalueCountSizeTerm MF anchored to membrane Ping WangMapping by BIM

SetPvalueQvalueCountSizeTerm MF7.41E extracellular region part MF7.53E extracellular region MF8.99E extracellular space Ping WangMapping by BIM

SetPvalueQvalueCountSizeTerm BP response to pheromone Ping WangMapping by BIM

Ping WangMapping by BIM qvaluePvalueCountSizeTerm steroid hormone receptor signaling pathway

SetPvalueQvalueCountSizeTerm BP enzyme linked receptor protein signaling pathway Ping WangMapping by BIM

SetPvalueQvalueCountSizeTerm BP vesicle organization and biogenesis Ping WangMapping by BIM

SetPvalueQvalueCountSizeTerm BP vesicle organization and biogenesis Ping WangMapping by BIM

Ping Wang 1 2 Mapping by BIM

Ping Wang 1 2 Mapping by BIM

Ping Wang 1 2 Mapping by BIM

Ping Wang 1 2 Mapping by BIM

Ping WangMapping by BIM

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