Growth Hormone Treatment in Children with Intrauterine Growth Retardation and Silver-Russell Syndrome Pierre Chatelain KIGS 10 Year Book, 1999.

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Presentation transcript:

Growth Hormone Treatment in Children with Intrauterine Growth Retardation and Silver-Russell Syndrome Pierre Chatelain KIGS 10 Year Book, 1999

P Chatelain - KIGS 10 Year Book, 1999 Definition and percentage of newborns with IUGR/SGA Based on Albertsson-Wikland et al 1993

Characteristics of IUGR/SGA patients enrolled in KIGS MPH, mid-parental height (1/3) P Chatelain - KIGS 10 Year Book, 1999

Characteristics of IUGR/SGA patients enrolled in KIGS (2/3) MPH, mid-parental height

P Chatelain - KIGS 10 Year Book, 1999 Characteristics of IUGR/SGA patients enrolled in KIGS (3/3) MPH, mid-parental height

P Chatelain - KIGS 10 Year Book, 1999 (1/3) Characteristics of patients with Silver-Russell syndrome enrolled in KIGS MPH, mid-parental height

P Chatelain - KIGS 10 Year Book, 1999 (2/3) Characteristics of patients with Silver-Russell syndrome enrolled in KIGS MPH, mid-parental height

P Chatelain - KIGS 10 Year Book, 1999 (3/3) Characteristics of patients with Silver-Russell syndrome enrolled in KIGS MPH, mid-parental height

(1/2) P Chatelain - KIGS 10 Year Book, 1999 First-year response to GH treatment of IUGR/SGA patients compared with the KIGS Prediction model for children with idiopathic GHD Predicted height velocity (cm/year) Studentised residuals

(2/2) P Chatelain - KIGS 10 Year Book, 1999 First-year response to GH treatment of IUGR/SGA patients compared with the KIGS Prediction model developed specifically for IUGR Predicted height velocity (cm/year) Studentised residuals

(1/2) P Chatelain - KIGS 10 Year Book, 1999 Longitudinal analysis over 4 years showing height related to chronological age in a subgroup of 79 patients with IUGR/SGA Box plots represent ranges (whiskers), 25th and 75th percentiles (shaded boxes), means (dots) and medians (rules) Duration of GH treatment (years) Height for chronological age (SDS) (n = 79)

(2/2) P Chatelain - KIGS 10 Year Book, 1999 Longitudinal analysis over 4 years showing height related to chronological age in a subgroup of 79 patients with IUGR/SGA Box plots represent ranges (whiskers), 25th and 75th percentiles (shaded boxes), means (dots) and medians (rules) Duration of GH treatment (years) Height velocity (cm/year)

(1/2) P Chatelain - KIGS 10 Year Book 1999 First-year response to GH treatment of patients with SRS compared with the KIGS prediction model for children with idiopathic GHD Predicted height velocity (cm/year) Studentised residuals

(2/2) P Chatelain - KIGS 10 Year Book, 1999 First-year response to GH treatment of patients with SRS compared with the KIGS prediction model developed for IUGR Predicted height velocity (cm/year) Studentised residuals

(1/2) P Chatelain - KIGS 10 Year Book, 1999 Longitudinal analysis over 4 years of height related to chronological age in a subgroup of 66 patients with SRS Box plots represent ranges (whiskers), 25th and 75th percentiles (shaded boxes), means (dots) and medians (rules) Duration of GH therapy (years) Height for chronological age (SDS)

(2/2) P Chatelain - KIGS 10 Year Book, 1999 Box plots represent ranges (whiskers), 25th and 75th percentiles (shaded boxes), means (dots) and medians (rules) Longitudinal analysis over 4 years of height velocity in a subgroup of 66 patients with SRS Duration of GH therapy (years) Height for chronological age (SDS)