Safety and Efficacy of Ultraviolet-A Light-Activated Gene Transduction for Gene Therapy of Articular Cartilage Defects by Michael D. Maloney, J. Jeffrey.

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Presentation transcript:

Safety and Efficacy of Ultraviolet-A Light-Activated Gene Transduction for Gene Therapy of Articular Cartilage Defects by Michael D. Maloney, J. Jeffrey Goater, Richard Parsons, Hiromu Ito, Regis J. O'Keefe, Paul T. Rubery, M. Hicham Drissi, and Edward M. Schwarz J Bone Joint Surg Am Volume 88(4): April 1, 2006 ©2006 by The Journal of Bone and Joint Surgery, Inc.

Ultraviolet A-induced cytotoxicity in human articular chondrocytes (AC) and human fibroblast- like synoviocytes (FLS). Michael D. Maloney et al. J Bone Joint Surg Am 2006;88: ©2006 by The Journal of Bone and Joint Surgery, Inc.

Ultraviolet A-induced rAAV transduction in human articular chondrocytes. Michael D. Maloney et al. J Bone Joint Surg Am 2006;88: ©2006 by The Journal of Bone and Joint Surgery, Inc.

Ultraviolet-induced pyrimidine dimer formation in human articular chondrocytes. Michael D. Maloney et al. J Bone Joint Surg Am 2006;88: ©2006 by The Journal of Bone and Joint Surgery, Inc.

Ultraviolet-induced reactive oxygen species levels in human articular chondrocytes. Michael D. Maloney et al. J Bone Joint Surg Am 2006;88: ©2006 by The Journal of Bone and Joint Surgery, Inc.

The in vivo effects of ultraviolet A-induced light-activated gene transduction in articular cartilage defects. Michael D. Maloney et al. J Bone Joint Surg Am 2006;88: ©2006 by The Journal of Bone and Joint Surgery, Inc.

Ultraviolet-A and rAAV-eGFP treatment does not affect the normal process of fibrous deposition and healing of the defect at seven days. Michael D. Maloney et al. J Bone Joint Surg Am 2006;88: ©2006 by The Journal of Bone and Joint Surgery, Inc.