Fluorodeoxyglucose Positron Emission Tomography Scanning: Basic Principles and Imaging of Adult Soft- Tissue Sarcomas by Ernest U. Conrad, Hannah D. Morgan,

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Presentation transcript:

Fluorodeoxyglucose Positron Emission Tomography Scanning: Basic Principles and Imaging of Adult Soft- Tissue Sarcomas by Ernest U. Conrad, Hannah D. Morgan, Cheryl Vernon, Scott M. Schuetze, and Janet F. Eary J Bone Joint Surg Am Volume 86(suppl 2): December 1, 2004 ©2004 by The Journal of Bone and Joint Surgery, Inc.

In the unstable atomic nucleus, a proton decays to a neutron. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

Coincidence timing and detection of the decay event. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

Glucose and fluorine-18 fluorodeoxyglucose (FDG) biochemistry. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

Dynamic quantification. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

Static quantification. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

Relapse-free survival curves by fluorine-18 fluorodeoxyglucose positron emission tomography response to chemotherapy, showing the difference between a reduction of >40% and a reduction of <40% in maximum standardized uptake value. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

Overall survival curves by fluorine-18 fluorodeoxyglucose positron emission tomography response to chemotherapy, showing the different overall survival between a reduction of >40% and a reduction of <40% in maximum standardized uptake value. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

A good response to treatment of a soft-tissue sarcoma of the thigh as seen by a substantial decrease in the maximum standardized uptake value (SUV) between baseline (left) and preresection (right) positron emission tomography scans. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

A poor response to treatment of a soft-tissue sarcoma of the hip as evidenced by a minimal decrease in the maximum standardized uptake value (SUV) between baseline (left) and preresection (right) positron emission tomography scans. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.

Disease progression as seen by an increase in the maximum standardized uptake value (SUV) over the interval between the baseline (left) and preresection (right) positron emission tomography scans. Ernest U. Conrad III et al. J Bone Joint Surg Am 2004;86: ©2004 by The Journal of Bone and Joint Surgery, Inc.