Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody by Davide Corti, John Misasi, Sabue Mulangu, Daphne A.

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Presentation transcript:

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody by Davide Corti, John Misasi, Sabue Mulangu, Daphne A. Stanley, Masaru Kanekiyo, Suzanne Wollen, Aurélie Ploquin, Nicole A. Doria-Rose, Ryan P. Staupe, Michael Bailey, Wei Shi, Misook Choe, Hadar Marcus, Emily A. Thompson, Alberto Cagigi, Chiara Silacci, Blanca Fernandez-Rodriguez, Laurent Perez, Federica Sallusto, Fabrizia Vanzetta, Gloria Agatic, Elisabetta Cameroni, Neville Kisalu, Ingelise Gordon, Julie E. Ledgerwood, John R. Mascola, Barney S. Graham, Jean-Jacques Muyembe-Tamfun, John C. Trefry, Antonio Lanzavecchia, and Nancy J. Sullivan Science Volume ():aad5224 February 25, 2016 Published by AAAS

Fig. 1 Isolation of antigen-specific monoclonal antibodies from Ebola virus disease survivor. Davide Corti et al. Science 2016;science.aad5224 Published by AAAS

Fig. 2 Characterization of purified EBOV GP monoclonal antibodies. Davide Corti et al. Science 2016;science.aad5224 Published by AAAS

Fig. 3 Binding regions and effector function. Davide Corti et al. Science 2016;science.aad5224 Published by AAAS

Fig. 4 Passive transfer of antibody cocktail. Davide Corti et al. Science 2016;science.aad5224 Published by AAAS