1. Sven Haller Haller, Nguyen, Rodriguez, Emch, Gold, Bartsch, Lovblad, Giannakopoulos

2. Alzheimer Disease Coronal MRI scan shows absence (left) and presence (right) of atrophy of the medial temporal lobe in a healthy elderly subject and a patient with AD van der Flier W M and Scheltens P (2005) Use of laboratory and imaging investigations in dementia. J Neurol Neurosurg Psychiatry v45-52

3. VBM in MCI VBM: 11 MCI versus 10 controls

4. VBM: individual patient ?

5. MCI: stable or progressive?

6. a c b SVM: basics

7. SVM: Classification of AD Kloppel S, Stonnington C M, Chu C et al (2008) Automatic classification of MR scans in Alzheimer's disease. Brain Pt 3:681- 689

8. Methods 35 Controls 67 MCI Neuropsy follow-up after 1 year  40 stable MCI  27 progressive MCI MRI at baseline  DTI  SWI  other (T2w….)

9. Sven Haller

10. TBSS

11. Results: DTI Haller, S., Nguyen, D., Rodriguez, C., Emch, J., Gold, G., Bartsch, A. J. et al. (epub). Individual prediction of cognitive decline in mild cognitive impairment using support vector machine-based analysis of diffusion tensor imaging data. J Alzheimers Dis.

12. Results: DTI Haller, S., Nguyen, D., Rodriguez, C., Emch, J., Gold, G., Bartsch, A. J. et al. (epub). Individual prediction of cognitive decline in mild cognitive impairment using support vector machine-based analysis of diffusion tensor imaging data. J Alzheimers Dis.

13. Sven Haller

14. Magnitude imagePhase mask image SWI image × = SWI: basics

15. GRE T2* HEMO SWI

16. Results: SWI Haller, S., Bartsch, A. J., Nguyen, D., Rodriguez, C., Emch, J., Gold, G. et al. (in press). Susceptibility weighted imaging (SWI) assessment of cerebral microbleeds and iron deposition in mild cognitive impairment. Radiology.

17. Results: SWI Haller, S., Bartsch, A. J., Nguyen, D., Rodriguez, C., Emch, J., Gold, G. et al. (in press). Susceptibility weighted imaging (SWI) assessment of cerebral microbleeds and iron deposition in mild cognitive impairment. Radiology.

19. Conclusions SVM classification sMCI versus pMCI  at baseline MRI  98% based on DTI  84% based on SWI Higher number of microbleeds for MCI vs HC  but no difference between sMCI and pMCI Iron accumulation  MCI increased iron in the right pallidum and right substantia nigra,  MCI decreased iron in the right red nucleus

20. THANK YOU! The End