1. Somatosensory System and Pain Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for research on Pain Institute of Life Sciences Hebrew University of Jerusalem lecture 6: Ascending pathways 08-9 פיסיולוגיה מורחב

2. primary sensory neurons perception vs. regulation

3. Spinal white matter pathways antero- lateral column dorsal column

4. dorsal column – medial lemniscus system hand foot A  LTM afferents

5. dorsal column nuclei thalamus (ventro-basal nucleus) VPL, VPM somatosensory cortex (S1) dorsal column – medial lemniscus system light touch and vibration sense

7. anterolateral column system (spino-bulbo-thalamic system) all types of afferents hand foot

8. thalamus (ventro-basal nucleus) VPL, VPM somatosensory cortex (S1) spino-bulbo- thalamic system which sense ? brainstem nuclei "bulbo-"

9. spino-bulbo- thalamic system

10. dorsal column – medial lemniscus system light touch and vibration spino-bulbo-thalamic system which sense ?? tabes dorsalis

11. anterolateral column system (spino-bulbo-thalamic system) all types of afferents hand foot

12. dorsal column – medial lemniscus system light touch and vibration spino-bulbo-thalamic system all somato-visceral senses

13. primary sensory neurons “medial pain pathway” lamina I (nociceptive)  parabrachial n. (pons)  amygdala + hypothalamus

15. succinyl dehydrogenase barrel field (van der Loos)

16. homunculus

17. functional magnetic resonance imaging fMRI

18. saggital human brain anterior cingulate gyrus

19. CCoghill et al. 2003 constant stimulus, variable sensory response among subjects

20. propriospinal system propriospinal tract

21. Somatosensory System and Pain Prof. Marshall Devor, Ph.D. Dept. of Cell & Animal Biology and Center for research on Pain Institute of Life Sciences Hebrew University of Jerusalem lecture 6: Ascending pathways פיסיולוגיה מורחב

22. primary sensory neurons

23. heterogeneity of primary afferents (  labeled line theory) heterogeneity of primary afferents (  labeled line theory) divergence + convergence  different heterogeneity of second divergence + convergence  different heterogeneity of second order projection neurons order projection neurons (2x specific, WDR, multireceptive) (2x specific, WDR, multireceptive) dynamic (RF size & response properties, central sensitization ) dynamic (RF size & response properties, central sensitization ) multiple ascending pathways multiple ascending pathways multiple terminal areas multiple terminal areas descending control (feedback, feedforward, anticipation) descending control (feedback, feedforward, anticipation) A Q P A Q P for every unique stimulus, a unique constellation of neural population activity Population activity theory "Population activity theory" “bottom-up” vs. “top-down”