1. Impact of Physical Activity on Glycemic Control and Prevalence of Cardiovascular Risk Factors in Adults With Type 1 Diabetes: A Cross- sectional Multicenter Study of 18,028 Patients Featured Article: Barbara Bohn, Antje Herbst, Martin Pfeifer, Dietmar Krakow, Stefan Zimny, Florian Kopp, Andreas Melmer, Jürgen M. Steinacker, and Reinhard W. Holl, for the DPV Initiative Diabetes Care Volume 38:1536–1543 August, 2015

2. STUDY OBJECTIVE To investigate whether there is an association between physical activity (PA) and glycemic control or cardiovascular risk in subjects with type 1 diabetes Bohn B.et al. Diabetes Care 2015;38:1536-1543

3. STUDY DESIGN AND METHODS 18,028 adults with type 1 diabetes from Germany and Austria in the Diabetes-Patienten-Verlaufsdokumentation (DPV) database were included Patients were stratified according to their self-reported frequency of PA Multivariable regression models were applied for glycemic control, diabetes-related comorbidities, and cardiovascular risk factors Data were adjusted for sex, age, and diabetes duration Bohn B.et al. Diabetes Care 2015;38:1536-1543

6. RESULTS An inverse association between PA and HbA1c, diabetic ketoacidosis, BMI, dyslipidemia, and hypertension, as well as between PA and retinopathy or microalbuminuria, was present Severe hypoglycemia did not differ in PA groups, whereas severe hypoglycemia with coma was inversely associated with PA Bohn B.et al. Diabetes Care 2015;38:1536-1543

7. CONCLUSIONS PA was beneficial with respect to glycemic control, diabetes- related comorbidities, and cardiovascular risk factors without an increase of adverse events Subjects with type 1 diabetes should perform regular PA Bohn B.et al. Diabetes Care 2015;38:1536-1543