1. CTIIP Coordination

2. Contract Period of Performance Digital Pathology and Integrative Query –July 24, 2014 – January 23, 2016 DICOM WG-30 –June 26, 2014 – June 25, 2015 Pilot Challenges –December 18, 2014 – June 17, 2016 Co-clinical and animal model data –April 15, 2015 – April 14, 2016

3. Timeline – Digital Pathology Support native WSI format in caMicroscope –Delivered to QA – March 2015 Tools and libraries to support the creation, consumption and management of PathAIM –Delivered to QA – August 2015 Support analytical services –Delivered to QA – November 2015 Pilot a data mashup and integrative query system –Delivered to QA – December 2015 3

4. Timeline - Pilot Challenges Evaluation of existing challenge platforms, standards, tools and technologies –Report due March 31, 2015 Develop MedICI system to support imaging (radiology and digital pathology) challenges –Development March to October 2015 –Deliver to QA – September 2015 Demonstrate the ability to host/execute pilot challenges using the challenge management system –Deploy Challenge Management System – September 2015 –Execute first challenge – October / November 2015 –Fine-tune system – November 2015 – January 2016 –QA refinements – March 2016 –Execute two more challenges – March to June 2016 4

5. Timeline – Co-clinical/animal model Submit Whole Slide Images and Demographics –May – October 2015 PathAIM mark up and annotations –June – October 2015 Prepare CMGI Images –May – July 2015 Mark up In-Vivo Images –July – August 2015 Submit CMGI images –July – November 2015 Identify and prepare human BrCa cases –July – September 2015 Submit human BrCA Images –November 2015 – April 2016 5

6. Dependencies / Linking of Projects Creation of PathAIM annotations and markups for animal images DigPath –Tools and libraries to support the creation, consumption and management of PathAIM Delivered to QA – August 2015 Co-Clinical –Submit Whole Slide Images and Demographics May – October 2015 –PathAIM mark up and annotations June – October 2015 6 UC Davis team to provide input on markup and annotations for animal images UC Davis team = user acceptance testing during development

7. DigPath –Pilot a data mashup and integrative query system Delivered to QA – December 2015 Co-clinical –Submit Whole Slide Images and Demographics May – October 2015 –PathAIM mark up and annotations June – October 2015 –Prepare CMGI Images May – July 2015 –Mark up In-Vivo Images July – August 2015 –Submit CMGI images July – November 2015 Need to agree where to store the data to make them accessible to the query system. 7 Dependencies / Linking of Projects Providing animal model/co-clinical data for integrated queries

8. Pilot Challenges –Execute two more challenges March to June 2016 Co-clinical –PathAIM mark up and annotations June – October 2015 –Mark up In-Vivo Images July – August 2015 –Submit CMGI images July – November 2015 –Submit human BrCA Images November 2015 – April 2016 8 Dependencies / Linking of Projects Providing animal model/co-clinical data for pilot challenge

9. Dependencies / Linking of Projects DICOM for animal model images Co-clinical –Submit CMGI images July – November 2015 DICOM WG-30 –Collecting images now –Images can be used as test cases DCB funded project develops DICOM wrapper tool –Coordination with DCB team (Rubin/Beck) needed 9

10. Working with the QA team Digital Pathology –QA Engineer Reza Mehri –Requirements before we go in QA Design Document Requirements Definition Document Architectural Review Checklist (ARC) –https://wiki.nci.nih.gov/display/sysdeploy/CTIIP+Digital+Patholo gy+ARChttps://wiki.nci.nih.gov/display/sysdeploy/CTIIP+Digital+Patholo gy+ARC Provision Target Environment (PTE) –https://wiki.nci.nih.gov/display/sysdeploy/CTIIP+Digital+Patholo gy+PTEhttps://wiki.nci.nih.gov/display/sysdeploy/CTIIP+Digital+Patholo gy+PTE –App scan for security vulnerabilities –508 compliance scan –Use the same QA server for Dig Path and Pilot Challenges? 10

11. Working with the technical writer Carolyn Klinger –Goal = make the CTIIP wiki public –User Documentation –Installation Guides 11

12. Coordination Meetings Once a month have all teams meet in a one-hour meeting to –Report progress –Discuss interactions and data delivery –Feedback on tools Find a timeslot 12

13. Resources CTIIP wiki –https://wiki.nci.nih.gov/x/XQJjCghttps://wiki.nci.nih.gov/x/XQJjCg 13