1. Delivering clinical research to make patients, and the NHS, better Sarcoma SSG 21 st October 2015 Research Surgeon Captain Professor, Rory Rickard Wendy Cook, Research Delivery Manager dd/mm/yyyy

2. Division 1- Cancer - Contacts Duncan Wheatley, Clinical Specialty Lead duncan.wheatley@rcht.cornwall.nhs.uk 01872 258312duncan.wheatley@rcht.cornwall.nhs.uk Rory Rickard, Sarcoma sub specialty lead roryrickard@me.com 01752 431515 roryrickard@me.com Wendy Cook, Research Delivery Manager wcook1@nhs.net 01392 406995 wcook1@nhs.net Ann Courtman, Administrator ann.courtman@nhs.net ann.courtman@nhs.net 01392 406966 2

3. Sarcoma Group National Perspective Data from Portfolio ODP – Cut off 25/09/15

4. Network 2014/20152015/2016 Commercial Non- Commercial TotalRankCommercial Non- Commercial TotalRank East Midlands0331000012 Eastern000140338 Greater Manchester019 3012 2 Kent, Surrey and Sussex0111201110 North East and North Cumbria035 20446 North Thames016 40993 North West Coast06670555 North West London044800012 South London0137 1026 1 South West Peninsula0001400012 Thames Valley and South Midlands010 50446 Wessex01112000 West Midlands022110774 West of England088601110 Yorkshire and Humber04480338 Sarcoma Group National Perspective

5. Key Issues/Messages No sarcoma recruitment last year or this year National Cancer Objectives - 4 1.Increase recruitment in rare cancer groups T2T. Networks will receive financial penalties if not met 5

6. CRN: South West Peninsula Annual Cancer Research Symposium 20 th May 2016 Taunton Conference Centre, Taunton Hosted by Musgrove Park Lead by Mo Varughese and Petra Jankowska Please contact Ann Courtman CRN: SWP Administrator, for further details and to register ann.courtman@nhs.netann.courtman@nhs.net 01392 406966 6

7. Sarcoma Group Open Studies Data from Portfolio ODP – Cut off 25/09/15 East Midlands StudyRecruitment Axi-STS3 CASPS2 Euro Ewing 20122 STS 2006 03 (NRSTS)4 Eastern StudyRecruitment Euro Ewing 20123 STS 2006 03 (NRSTS)9 Greater Manchester StudyRecruitment A study of selumetinib in patients with Kaposi’s sarcoma (SCART)2 Axi-STS17 CASPS7 Euro Ewing 201217 rEECur3 STS 2006 03 (NRSTS)24 Kent, Surrey and Sussex StudyRecruitment A study of selumetinib in patients with Kaposi’s sarcoma (SCART)4

8. Data from Portfolio ODP – Cut off 25/09/15 Sarcoma Group Open Studies North East and North Cumbria StudyRecruitment CASPS3 Euro Ewing 20124 Optimisation of Circulating Tumour Cell Detection in Bone Sarcomas4 STS 2006 03 (NRSTS)17 North Thames StudyRecruitment Axi-STS27 CASPS2 Euro Ewing 201210 rEECur3 STS 2006 03 (NRSTS)34 North West Coast StudyRecruitment Axi-STS7 EORTC-1202-STBSG1 Euro Ewing 20124 rEECur2 STS 2006 03 (NRSTS)12 North West London StudyRecruitment A study of selumetinib in patients with Kaposi’s sarcoma (SCART)11

9. Sarcoma Group Open Studies Data from Portfolio ODP – Cut off 25/09/15 South London StudyRecruitment Axi-STS52 CASPS8 EORTC-1202-STBSG2 Euro Ewing 20121 ISKS study118 PIRS26 Profiling and culturing of neuroblastoma and soft tissue sarcoma cells6 STRASS (EORTC 62092-22092)11 STS 2006 03 (NRSTS)16 Thames Valley and South Midlands StudyRecruitment Axi-STS5 Euro Ewing 20124 LINES: Eurosarc Trial of Linsitinib in advanced Ewing Sarcoma8 MEMOS: A Eurosarc Study of Mifamurtide in advanced osteosarcoma1 STS 2006 03 (NRSTS)3 Wessex StudyRecruitment Axi-STS5 Euro Ewing 20121 STS 2006 03 (NRSTS)9

10. Sarcoma Group Open Studies Data from Portfolio ODP – Cut off 25/09/15 West Midlands StudyRecruitment Euro Ewing 20122 Ewings Genotype3 STRASS (EORTC 62092-22092)2 STS 2006 03 (NRSTS)4 West of England StudyRecruitment Axi-STS5 CASPS1 Euro Ewing 20121 STRASS (EORTC 62092-22092)1 STS 2006 03 (NRSTS)21 Yorkshire and Humber StudyRecruitment A study of selumetinib in patients with Kaposi’s sarcoma (SCART)2 Axi-STS13 Euro Ewing 20122 STS 2006 03 (NRSTS)22