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Slamf1 -/- [ BALB/c.129] wt BALB/c 1000 2000 3000 4000 IgM IgG1 IgG2a IgG2b IgG3 IgA 250 500 750 1000 IgM IgG1 IgG2a IgG2b IgG3 IgA Slamf2 -/- [ BALB/c.129]

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Presentation on theme: "Slamf1 -/- [ BALB/c.129] wt BALB/c 1000 2000 3000 4000 IgM IgG1 IgG2a IgG2b IgG3 IgA 250 500 750 1000 IgM IgG1 IgG2a IgG2b IgG3 IgA Slamf2 -/- [ BALB/c.129]"— Presentation transcript:

1 Slamf1 -/- [ BALB/c.129] wt BALB/c 1000 2000 3000 4000 IgM IgG1 IgG2a IgG2b IgG3 IgA 250 500 750 1000 IgM IgG1 IgG2a IgG2b IgG3 IgA Slamf2 -/- [ BALB/c.129] wt BALB/c Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1A

2  Slamf1 -/- [ B6.129] wt B6 500 1000 1500 2000 1 mo 2 mo 3 mo 6 mo IgM   250 500 750 1000 1 mo 2 mo 3 mo 6 mo IgG1  Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S1B

3 F M 0 25 50 75 100 % autoantibody + Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S2

4 B6 CD244  Slamf Haplotype 1  Slamf Haplotype 2 Sle1b Slamf2-/- [B6.129] Slamf1/- [B6.129] 1.2598.872.627.41.039993.66.420.7199.3712984.415.60.399.7 Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S3

5 CD4-PE + PNA-FITC CD4-PE + B220-FITC wt BALB/c Slamf2-/- [BALB/c.129] Slamf1-/- [BALB/c.129] Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S4

6 Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S5A p < 0.001 3 months6 months Slamf2-/- [B6.129] Slamf2-/- [B6.129] B6

7 Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S5B 3 months6 months Slamf2-/- [B6.129] Slamf2-/- [B6.129] B6

8 B6.129chr1b (26) B6.Sle1b (13) 129/NZW allele B6 allele Slamf2-/- [B6.129] recombinant region 10Mb Autoimmunity in Slamf1-/- and Slamf2-/- mice Supplement Fig S6

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