1. INFSO-RI-508833 Enabling Grids for E-sciencE Grid based telemedicine application for GATE Monte Carlo dosimetric studies using HOPE (Hospital Platform for E-health) Lydia MAIGNE, PhD Laboratoire de Physique Corpusculaire maigne@clermont.in2p3.fr Credits: M.Diarena, S.Nowak, C. Thiam, D.Donnarieix and V.Breton

2. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 2 Better treatment requires better planning Today: analytic calculation to compute dose distributions in the tumor or to model scans – For new Intensity Modulated Radiotherapy treatments, analytic calculations off by 10 to 20% near heterogeneities – Quantification of the radioactivity inside an organ or a tumor after an internal dosimetry treatment very difficult to perform Better alternative: Monte Carlo (MC) simulations unacceptable time consuming The GRID impact: reduce MC computing time to a level acceptable by the physician

3. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 3 GATE: Geant4 Application for Tomographic Emission noyau GEANT4 Développements dédiés SPECT/TEP GATE  Goal: Develop a platform dedicated to PET and SPECT applications  Ensure a long terme development Based on Geant4 Dedicated tools for imaging Easy to use Shared developement OpenGATE collaboration

4. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 4 Medical physics Application Some examples of medical physics applications: PET camera Ocular brachytherapy treatment Radiotherapy OpenGATE collaboration http://www.opengatecollaboration.org

5. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 5 Pseudorandom number sequences  Random numbers consumption depends of: interactions, number of particles générated, etc…  Linear RN consumption in function of the number of particles generated x15x14x13x12x11x10x9x8x7x6x5x4x3x2x1 status000.rndmstatus001.rndmstatus002.rndm Status 1Status 2Status 3 u 1000 status of the Random Number Generator with a length of 3.10 10 numbers.

6. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 6 6°) Split the simulations: A GATE simulation generating a lot of particles in matter could take a very long time to run on a single processor – So, the big simulation generating 10M of particles is divided into little ones, for example  10 simulations generating 1M of particles  20 simulations generating 500000 particles  50 simulations generating 200000 particles …… – All the other files needed to launch Monte Carlo simulations are automatically created with the program. jdl files jobXXX.jdl Script files scriptXXX.csh Required files Macro files macroXXX.mac Status files statusXXX.rndm

7. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 7 An ocular brachytherapy treatment 2°) Treatment planning Calculation of deposit dose on the tumor (~1mn): A treatment plan is developed using the images 1°) Obtain scanner slices images The head is imaged using a MRI and/or CT scanner 3°) Ocular brachytherapy treatment Irradiation of the ocular tumor using an ophthalmic applicator

8. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 8 HOPE portal

9. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 9 How it works on the grid The telemedicine infrastructure allows users to exchange medical data from different hospitals. The information exchange takes place between web services deployed in different locations and is completely transparent to end users. Information are transferred between different locations only on request using SOAP messages over an SSL secured channel. Security:

10. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 10 1°) The connexion: to a smart adaptive identifier Patient smart card –The card will host an identifier based on hash value of name, birth and family components –Each medical act is stored as a small string in the card Encryption –Between the PACS server and the web portal, patient ID and medical act will be a part of a key used to encrypt images to secure transactions Data retrieval system –A secure authentication for patients to retrieve their personal data Physician authentication –Healthcare professional smart card + Password Look at the poster of Paul de Vlieger: Smart adaptive identifier for a medical data retrievement system

11. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 11 1°) Enter a new patient: patient sheet

12. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 12 2°) Obtain the medical images of the tumor from the PACS system Scanner slices: DICOM or DICOMRT format Scanner slices of the patient brain in DICOM or DICOMRT format  Size of the scan slices: 512 X 512 X 1 pixels  Size of a voxel in the image: 0,625 X 0,625 X 1,25 mm

13. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 13 2°) Obtain the medical images of the tumor from the PACS system

14. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 14 3°) Register and replicate the binary image on SEs:StorageElement ComputingElement StorageElement ComputingElement StorageElement ComputingElement StorageElement ComputingElement Image: text file Binary file: Image.raw Size 19M Scanner slices: DICOM format Anonymisation Concatenation DICOM Viewer Site 1 Site 2 Site 3 Site 4 User interface Copy image.raw on a SE Replicate image on the other SEs

15. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 15 4°) Register the confidential data: Image: text file Binary file: Image.raw Size 19M Scanner slices: DICOM format AMGA Database Anonymisation Concatenation StorageElement ComputingElement StorageElement ComputingElement StorageElement ComputingElement StorageElement ComputingElement Site1 Site2 Site3 Site4 Register lfn in the database Query a lfn to the database User interface

16. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 16 5°) Submission on the Grid: StorageElement ComputingElement StorageElement ComputingElement StorageElement ComputingElement StorageElement ComputingElement GATE Image: text file Binary file: Image.raw Size 19M Scanner slices: DICOM format AMGA Database User interface Site1 Site2 Site3 Site4 Anonymisation Concatenation Submission of jdls to the CEs Copy the medical image from the SE to the CE Retrieving of root output files from CEs

17. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 17 5°) Submission on the Grid:

18. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 18 6°) Results: Treatment plans

19. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 19 Computing time tests

20. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 20 Conclusion and perspectives New convivial web platforms for different biomedical applications Tools begin to be used by medical staff Grid stability, EGEEIII infrastructure Develop convivial end users tools to be used in hospital Federate the communities (the HealthGrid association) Confidential data, legal issues Think about the electronic medical patient file and how the grid could deal with in a near future.

21. Enabling Grids for E-sciencE Lydia Maigne EGEE User Forum – Clermont-Ferrand - 11-14 February 2008 21 References EGEEII biomedical applications: –http://egee-na4.ct.infn.it/biomed/egee2-applications.html WISDOM: –www.wisdom.healthgrid.org LifeGrid project: –www.lifegrid.org GATE Monte Carlo platform: –www.opengatecollaboration.org HealthGrid initiative: –www.healthgrid.org Contacts: –PCSV team web site: http://clrwww.in2p3.fr/PCSV –Lydia Maigne: maigne@clermont.in2p3.frmaigne@clermont.in2p3.fr