1. IMMUNOLOGY II
CHAPTER 18

2. Immunological Disorders
Hypersensitivity - allergy
Immunodeficiency

3. Type I Hypersensitivity (Anaphylactic)
Anaphylaxis
Localized vs. Generalized
Mechanism
Treatment - epinephrine
benadryl

4. Type I Hypersensitivity (Anaphylactic)

5. Type II Hypersensitivity (Cytotoxic)
Mechanisms
Examples
Wrong blood type

6. Hemolytic Disease of the Newborn

7. Hemolytic Disease of the Newborn

8. Type III Hypersensitivity (Immune Complex)
Mechanism
Examples

9. Type IV Hypersensitivity (Cell-mediated)
Mechanism
Examples

10. Autoimmune Disease
Mechanism
Examples
Severe rheumatoid arthritis

11. Other examples:
Graves disease, lupus, crohn’s disease, MS

12. Transplantation Issues
Rejection
Tolerance
Immunosuppression
predisilone, methotrexate

13. Immunodeficiency Disorders
Primary
Secondary

14. AIDS (Acquired Immunodeficiency Syndrome)
Disease Progression
Epidemiology

15. CDC AIDS Classification System

16. AIDS Spread
Risk Population
Vaccine ???

17. Global HIV

18. Precipitation Tests
Precipitation
Immunodiffusion

19. Agglutination Tests
Agglutination
Hemagglutination

20. Complement Fixation
Ab/Ag complex competition

21. Immunological Tests (cont.)
Neutralization
Immuno-
fluorescence

22. ELISA Tests

23. Western Blots
Protein profiling