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Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses James P. Clement, Massimiliano Aceti, Thomas.

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Presentation on theme: "Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses James P. Clement, Massimiliano Aceti, Thomas."— Presentation transcript:

1 Pathogenic SYNGAP1 Mutations Impair Cognitive Development by Disrupting Maturation of Dendritic Spine Synapses James P. Clement, Massimiliano Aceti, Thomas K. Creson, Emin D. Ozkan, Yulin Shi, Nicholas J. Reish, Antoine G. Almonte, Brooke H. Miller, Brian J. Wiltgen, Courtney A. Miller, Xiangmin Xu, Gavin Rumbaugh Cell Volume 151, Issue 4, Pages 709-723 (November 2012) DOI: 10.1016/j.cell.2012.08.045 Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

2 Figure 1 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

3 Figure 2 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

4 Figure 3 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

5 Figure 4 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

6 Figure 5 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

7 Figure 6 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

8 Figure 7 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

9 Figure 8 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

10 Figure S1 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

11 Figure S2 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

12 Figure S3 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

13 Figure S4 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

14 Figure S5 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

15 Figure S6 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

16 Cell 2012 151, 709-723DOI: (10.1016/j.cell.2012.08.045) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

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