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Geula & Mesulam, Cerebral Cortex 1996, 6:165-177 Age-matched controlAlzheimer’s disease.

Published byDamian Barker Modified over 9 years ago

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Presentation on theme: "Geula & Mesulam, Cerebral Cortex 1996, 6:165-177 Age-matched controlAlzheimer’s disease."— Presentation transcript:

1 Geula & Mesulam, Cerebral Cortex 1996, 6:165-177 Age-matched controlAlzheimer’s disease

2 The attentional abilities which depend on the integrity of cortical cholinergic inputs range from: the detection, selection, and discrimination of stimuli and associations (sustained and selective attention) to the regulation of processing capacity (divided attention). Attentional functions of the cortical cholinergic input system:

3 EVIDENCE LINKING CORTICAL ACh RELEASE TO ATTENTION HUMANS: CORRELATION BETWEEN COGNITIVE DEFICITS IN ALZHEIMER’S DISEASE AND LOSS OF BASAL FOREBRAIN CHOLINERGIC NEURONS; DRUGS THAT INCREASE ACh RELEASE CAN FACILITATE ATTENTION RATS: DRUGS OR LESIONS THAT DECREASE CORTICAL ACh RELEASE IMPAIR ATTENTIONAL PROCESSING & THESE DEFICITS CAN BE ATTENUATED WITH DRUGS THAT POTENTIATE STIMULATE ACh RELEASE; CORTICAL ACh RELEASE IS STIMULATED DURING PERFORMANCE OF ATTENTIONAL TASKS

4 CORTICAL ACh AND ALZHEIMER’S DISEASE THE HUNDRED BILLION $$$$ QUESTION! IF THE COGNITIVE DEFICITS IN ALZHEIMER’S DISEASE REFLECT DECREASED CORTICAL ACh, THEN WHY AREN’T DRUGS THAT INCREASE CORTICAL ACh RELEASE MORE THERAPEUTIC?

5 Human cortex Rat cortex Cortical cholinergic inputs and cognitive function

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