1. Hemorrhagic strokePROF.SHKROBOT

2. Stroke morbidity in different countries 1:3,6 1:7 Hemorrhagic stroke Ischemic stroke per 100 OOO of population

3. Stroke morbidity per 100 000 of population

4. Stroke mortality in different countries per 100 000 of population

5. Mortality from different types of stroke in Ukraine per 100 000 of population

6. Nowadays

7. ... Every fifth Ukrainian resident will die of stroke...

8. Every fifth one will finish his life as depending from others disabled person

9. Stroke is acute disorders of cerebral circulation, rapidly developing clinical signs of focal (at times global) disturbance of cerebral function, lasting more than 24 hours or leading to death with no apparent cause other then that of vascular origin

10. According to World Health Organization classification of all cerebrovascular diseases are divided into 3 groups: 1. Premonitary and initial symptoms of brain blood supply insufficiency 2. Acute cerebral blood circulation disturbances a) Dynamic cerebral blood circulation disturbances Hypertonic crisis Acute hypertonic encephalopathy b) Strokes: Haemorrhage subdural, epidural intracerebral haemorrhage ventricular hemorrage Ischemic Cardioembolic Atherothrombotic Hemodynamic Rheologic Lacuna

11. According to World Health Organization classification all cerebrovascular diseases are divided into 3 groups: 3. Dyscirculative encephalopathy or chronic cerebral blood circulation insufficiency or slowly progressive insufficiency of cerebral blood circulation I st II st III st Dyscirculative myelopathy or chronic spinal blood circulation insufficiency

12. Hemorrhagic stroke Intracerebral ( when the hemorrhage is into the substance or parenchyma of the brain ) Membrane –subarachnoid (when the bleeding originates in the subarachnoid spaces surrounding the brain) –epidural and subdural Combined –subarachnoid – parenchymatose –parenchymatose– subarachnoid –parenchymatose–ventricular –ventricular

13. Blood supplying of brain

14. The most common causes of hemorrhage are: Hypertension Symptomatic arterial hypertension (at kidney diseases, systemic vessel processes) Inborn arterial and arterio – venous malformations Blood diseases (leucosis, polycythemia) Cerebral atherosclerosis Intoxications, such as uremia, sepsis

15. Аneurism

16. LOKALIZATION

17. Localization of hemorrhages

18. Ventricular hemorrhage

19. According to the localization there are : Lateral hemorrhage ( they are located laterally compared with the internal capsule )

20. Medial hemorrhage (they are located medially compared with the internal capsule)

21. Combined hemorrhages (they take the whole region of basal nuclei: subcortical nuclei, thalamus, internal capsule)

22. Brain stem hemorrhages Cerebellar hemorrhages

23. In hemisphere

24. In ventricules

25. Pathomorphology Per rexis Per diapedesis

26. MRI

27. The main periods of stroke Acute (up to 3 – 4 months) Renewal (up to 1 year) Residual

28. Stages of acute period Precursors Apoplectic stroke Focal signs

29. General cerebral symptoms severe headache nausea vomiting seizures consciousness disorders -sopor -stupor -semicoma -coma

30. Coma is characterized by deep consciousness disorder, disturbance of breathing and heart activity. The patient doesn’t respond to stimuli.

31. C o m a response to stimuli is absent eyes are closed, mouth is opened face is red, lips are cyanotic, skin is cold, neck vessels are pulsing there is breathing disturbance pulse is strained and slow blood pressure is increased temperature increases in 24 hours patient is lying on his back all muscles are relaxed pupils are changed (there can be anizokoria, cross – eyes, sometimes gaze paresis can be observed) mouth angle is a little bit lower

32. On pathology side 1 Pupils are changed: anizokoria, midriasis cross – eyes gaze paralysis 2 Painful Trigeminal and Occipital points 3 Pain in eyeballs 4 Bechterev phenomena present 5 Meningeal signs present 6 Automatic movements

33. On the opposite side hemiplegia is often observed: positive Bare sign the arm is falling down like bine there is hypotonia of muscles reflexes are low Babinski sign is often observed too mouth angle is a little bit lower foot is turned outside

34. Large hemisphere hemorrhage meningeal signs vomiting and dysphagia retention of urine or involuntary urination in case of cortex irritation epileptic attacks

35. Secondary brain stem syndrome progressive breathing disorders disturbance of heart activity consciousness disorders disturbance of eye movements changes of muscle tonus (hormetonia) autonomic disorders (sweating, tachycardia, hyperthermia)

36. Brain stem hemorrhage tetraparesis alternating syndromes eye movements disorders Nystagmus gorge disorders cerebellar syndromes.

37. Pons hemorrhage ptosis gaze paresis increased muscular tone (hormetonia)

38. Cerebellar hemorrhage Dizziness Severe headache in occipital lobe Vomiting Eye movements disorders Ptosis Gervig – Mazhandi syndrome, Parino syndrome Cerebellar symptoms - nystagmus, dysartria, hypotonia, ataxia Paresis of extremities is not common

39. Complication of intracerebral hemorrhage is rupture into the ventricle system. This is usually associated with: worsening of patient’s state Hyperthermia breathing disorders hormetonia manifests as changes of muscle tone in extremities, when hypotonia is changed into hypertonia in a few seconds or minutes.

40. Diagnostics In blood usually leucocytosis, related lymphopenia, hyperglycemia (up to 8 – 10 mmole per liter) In liquor high pressure during lubar puncture a great number of erythrocytes are found On eye fundus – retinal hemorrhages, hypertonic angioretinopathy and Salus symptoms are observed At echoencephaloscopy there is dislocation of middle structures on 6 –7 sm to the healthy side At angiography - aneurysm, dislocation of blood vessels, to find out zone “without vessels“ CT and MRI find out hyperdensive focuses.

41. In liquor high pressure during lubar puncture a great number of erythrocytes are found 1. normal 2. subarachnoid hemorrhage 3. intracerebral hemorrhage 4. xantochromia

42. On eye fundus – retinal hemorrhages, hypertonic angioretinopathy and Salus symptoms are observed 1-2 embolism of retinal vessels 3 – hypertensive encephalopathy 4 – subarachnoid hemorrhage

43. At echoencephaloscopy there is dislocation of middle structures on 6 –7 sm to the healthy side

44. Angiography

45. Brain CT – scan

46. Brain CT - scan Ab

47. MRI Arteriovenose malformation

48. Medial hemorrhage

51. Aneurism of left cerebral artery Hemorrhage in thalamus

52. Differential diagnosis Infarction of brain (thrombembolic) Epistatus Uremic coma Diabetic coma Traumatic hemorrhage Brain tumor with inside hemorrhage

53. Subarachnoid hemorrhage Aetiologic factors: Aneurysmatic ( 50 – 62 % ) – aneurysm rupture. Hypertensive ( at hypertension ) Atherosclerotic ( 15 % ) Traumatic ( 5 – 6 % ) Infectious – toxic ( 8.5 % ) Blastomatose ( at tumors ) Pathohemic ( at blood diseases ) Cryptogenic ( 4 – 4.8 % )

54. Frequency of sub arachnoid hemorrhage 6 - 16 (in average 10) per 100 000 population in a year SAH – 10 % from all CVD, 0.5% in mortality structure Recurring non traumatic SAH – in 26,5 % (mortality – up to 70 %) In 10 % of patients with AVM was diagnosed AA

55. Clinical features Severe headache or feeling of hot liquid flowing in the brain (pain is local in the region of occipital lobe). Later pains in neck, back appear, sometimes they irradiate in legs. Simultaneously with headache vomiting and nausea occur. there are other general cerebral symptoms: short loss of consciousness, psychomotor excitement, seizures.

56. Aneurysm

57. Clinical features Meningeal syndrome rigidity of occipital muscles symptoms of Kernig, Brudzinsky general hyperesthesia. Significant focal neurologic symptoms are not common. Only in case of basal hemorrhage CNs suffer (that is the reason of ptosis, cross – eye, dyplopia, paresis of mimic muscles). That’s why lesion of CNs is typical for basal aneurysm rupture.

59. Kernig’s sign

60. The main reasons of complications - recurring ruptures of MA (25% during 2 weeks, 50% during 6 months). Mortality up to 70%. The highest risk is (4%) in first day. Usually in more severe patients. - development of arterial spasm (in 50% of patients) Mortality + disability - 20-27% due to secondary ischemic lesions in brain tissue

61. Complications Brain edema Recurrent SH Occlusive hydrocephalia Brain infarction

62. Hydrocephalus 11 2 33 4 Lateral ventricle 3rd ventricle 4th ventricle

63. Diagnosis Stroke – like development with general cerebral and meningeal symptoms and absence of significant focal neurologic deficit The presence of blood in liquor (bleeding liquor during first day and yellow liquor on 3rd – 5th day) Retinal hemorrhages are on eye fundus

64. Differential diagnosis Meningitis Acute food toxic infection Infectious diseases

65. Hospitalization For adequate treatment the patient should be hospitalized in stroke unite

66. Strokes treatment Nondifferential treatment includes: Prevention and treatment of pulmonary insufficiency Elimination of heart – vascular disorders Brain edema treatment Normalization of water – electrolytes balance and acid – alkali balance Osmosis correction Improving of brain metabolism Elimination of hyperthermia and other autonomic disorders

67. Prevention and treatment of pulmonary insufficiency –the patient is lying on the bed with his head elevated –cleaning of patient’s oral cavity –tracheostomia ( at inspiratory muscles paralysis ) –at lung edema - oxygen; narcosis, Bobrov’s apparatus, 2 ml 1 % lazix, 2 ml 1 % dimedroli, 2 ml 0.1 % atropini I/m –antibiotics are used in order to prevent pneumonia

68. Elimination of heart – vascular disorders At increased blood pressure we use Clofelini 1 – 3 ml 0.01 % solution i/m, i/v. Dibasoli 3 – 4 ml 1 % solution i/v Droperidoli 1 ml 0.25 % solution i/v Rasedili 1 – 2 ml 0.1 % i/v, I / m,  - adrenoblockers ( anaprilini, obzidani, inderali ) peripheral vasodilatators ( Natrii nytroprussidi, appresini ) in combination with euphyllini

69. In low blood pressure we prescribe Dexamethazoni 4 – 8 mg i/v by drops in physiological solution Prednizoloni 60 – 120 mg i/v by drops in physiological solution In order to improve heart activity we use strofantini, corgliconi, cordiamini

70. Brain edema treatment Diuretics Corticosteroids Albumini Ganglioblockers 20 % Mannit Manitoli Glycerini Lazix Diakarbi

71. Normalization of water – electrolytes balance and acid – alkali balance We should estimate patient’s necessity in water according to his secretion, the level of Na in blood, hematocritis An average water necessity is 35 ml per kg, in patients with loss of consciousness it is 50 ml per kg We should correct patient’s hyper- or hyponatriemia, hyper- or hypokaliemia 4 % solution of Na bicarbonates i/v, trisaminum is used at metabolic acidosis. KCl i/v is used at metabolic alkalosis

72. Osmosis correction Normally blood osmose is within 280 – 295, urine osmose is 600 – 900 moms per liter At stroke usually we have hyperosmose, which manifests as increased hematocritis, hyperagrigation

73. Improving of brain metabolism Vit E Piracetami Aminaloni cerebrolysini natrii oxybutiras

74. Liquidation of hyperthermia and autonomic disorders. analgini 50 % 2.0 aspizoli 0.5 g sibazoni 0.5 % 1 ml haloperidoli 0.5 % 1 ml dimedroli 1 % 2 ml natrii oxybutiras 20 % 10 ml

75. To lower increased blood pressure Clofelini,  - aqdrenoblockers (anaprilini, obzidani, inderali ), Calcium antagonists ( nifidipini, adalat ) IACE ( capoten, enalapril, renarapril ) are used Mg sulfatis 25 % 5-10 ml i\v At too high blood pressure ganglioblockers are used: Pentamini 5% 1.0 Benzohexonium 2.5 % 1 ml Arfonid 5 ml 5 % i/v in physiologic solution

76. Differential treatment of brain infarction To renew blood circulation in zone of ischemia To correct rheologic and coagulative properties of blood, to improve microcirculation To prevent disorders of cerebral metabolism To decrease brain edema To treat brain hypoxia

77. Differential treatment of hemorrhage The main directions of treatment are: –To lower increased blood pressure –To liquidate brain edema and lower intracranial pressure –To increase coagulative properties of blood and decrease penetrance of vessels’ wall –To prevent and treat cerebral vessels spasm –To normalize vital and autonomic functions and prevent complications –To treat hypoxia and brain metabolism disorders

78. Differential treatment of hemorrhage The main directions of treatment are: –To lower increased blood pressure –To liquidate brain edema and lower intracranial pressure –To increase coagulative properties of blood and decrease penetrance of vessels’ wall –To prevent and treat cerebral vessels spasm –To normalize vital and autonomic functions and prevent complications –To treat hypoxia and brain metabolism disorders

79. To increase coagulate properties of blood –CaCl2 10 – 20 ml 10 % i/v –Vicasoli 1 – 2 ml 1 % i/v –Ascorbinic acid 2–5 ml 5–10 % solution I/m Antifibrinolytics : –EAKA 100 ml 5 % solution 1–2 times per day I/v by drops during 5 – 7 days. Then we use it orally – 3 g every 3 – 4 hours up to 3 weeks.

80. To increase coagulate properties of blood At decompensated fibrinolysis we use: –Trasiloli 20 – 30 000 U i/v by drops in 250 ml of physiologic solution –Hordox 5 000 U i/v by drops every other day. to normalize microcirculation we use –dicinoni 2 ml 12.5 % solution 2 – 3 times per day during 10 days, then 2 tablets ( 0.5 g ) every day. –Ascorutini, rutamini ( 1 ml i/m 1 – 2 times per day ).

81. To prevent and treat cerebral vessels spasm Antagonists of Calcium are used: Nimotop is introduced I / v 15 mg per kg per day during 5 – 6 hours. On the 5th – 7 th day it is used orally 60 mg every 4 hours during 7 – 10 days.

82. Symptomatic treatment At severe headache baralhini 5 mli/ v, combination of analgini ( 4 ml 50 % solution ) with 1 ml 1 % dimedroli and novocaini 5 ml 0.5 % solution; promedoli are used. At vomiting haloperidoli 1 – 2 ml 0.5 % solution droperidoli 1 ml 0.25 % solution are used. At seizures sibazoni 2 – 4 ml 0.5 % solution, natrii oxybutiras 10 ml 20 % solution i/v are used. Surgical treatment is used at lateral or lobar hemorrhages less the 100 ml. At subarachnoid hemorrhages surgical treatment is recommended during first 48 hours or on the second week.