1. 課程名稱： 論文選讀（下） - 2008 學分數： 1 開課系所： 生科四（甲） 上課時間： Tue, 1:40~3:30 PM 任課教師： 賴金美老師（  bio2028@mails.fju.edu.tw ）上課地點： ES 508 週次日期課程內容週次日期課程內容 1 2 月 26 日 專討課程介紹與評分方式9 4 月 22 日 期中考週（停課） 2 3 月 04 日 特別演講（ ES609 ） 10 4 月 29 日 余明泰、譚國斌 3 3 月 11 日 專討諮詢（不上課）11 5 月 06 日 劉姿瑩、羅珮純 4 3 月 18 日 藍娬娟、吳宜靜 12 5 月 13 日 黃鈺雲、黃威呈 5 3 月 25 日 唐逸品、黃勝偉 13 5 月 20 日 6 4 月 01 日 粱博凱、林亞君 14 5 月 27 日 7 4 月 08 日 尤聰健、酆茂蓉 15 6 月 03 日 畢業考週 8 4 月 15 日 許庭毓、郭培群 16 6 月 10 日 期末考週

2. 需撰寫摘要；摘要需於前一週 W5 前交給老師以做修改，並於報告 當天發給每位同學。 口頭報告 40 分鐘，同學或老師提問 10 分鐘。 由前一週同學負責借用及歸還投影機並擔任該週報告之主持人 （負責介紹及發問）。 評分： Presentation: 60% [Abstract (20%); Presentation & Discussion (40%)] Raising question: 15% Final report (modified power point file): 15% 出席率： 10% （遲到扣分： 0.5 分 / 次）

3. Cell migration in 3D ECM Review article Tumor-cell invasion and migration: diversity and escape mechanisms Nature Review 2003 (3) 362-374

4. Cell migration in 3D ECM

7. Many studies confirm that the multistep model of cell migration applies to cancer cells. ECM-degrading enzymes, such as matrix metalloproteinases (MMPs) are frequently upregulated in tumor cells, and facilitate migration in vitro, as well as dissemination and metastasis in vivo. The overexpression or activation of the Rac, Rho, ROCK or MLCK signaling pathways have been correlated with in vitro tumor cell migration, as well as in vivo invasion and progression. Pharmacological inhibitors that block integrins, MMPs, ROCK or MLCK are being developed to interfere with cancer-cell invasion. Cancer therapeutics designed to target adhesion receptors or proteases have not yet been show to be effective in clinical trials. This might be due to the fact that the cancer cell’s migration mechanisms can be reprogrammed, allowing it to maintain its invasive properties via morphological and functional de- differentiation.

8. * Epithelial-Mesenchymal Transition (EMT)

9. * Intercellular junctional complex apical basal

10. Cell-cell adhesion results from interaction between extracellular domains of cadherins from opposing cells to form a "cell adhesion zipper", which, if extensive, would hold cells together with great strength different cell types might engage in different types of interactions   The greater the number of interacting cadherins in a cluster, the greater the strength of adhesion between apposing cells

11. Embryonic development is characterized by changes in gene expression, cell shape, cell motility, cell adhesion, etc. Mesenchyme (loose, primarily nonadhesive cells) Epithelium (tightly adherent, organized cell layer) * mesenchymal-epithelial transition N-cadherin

12. Sites of EMT and MET in the emergence and progression of carcinoma. Nature, Vol. 2, 442-454

13. Drivers and mediators of EMT. Cell, Vol. 118, 277-279 The morphological transition of EMT was accompanied by scattering and directional migration toward serum factors, a gain of mesenchymal cell markers (fibronectin, vimentin, and N-cadherin), and a loss of epithelial markers (E-cadherin, and  - and g-catenin).