1. Do Now: Can you figure out the coded message? EOB JT B DPEF! DNA IS A CODE!

2. DNA Basics DNA is a chemical polymer made of nucleotides. The order of nucleotides in a DNA molecule are instructions for making proteins. A gene is a piece of DNA for making 1 protein

3. Codes There’s a code that allows people to say and write whatever they want – it’s called the alphabet. Each “bit” is a letter that “codes for” a specific sound. Certain sounds in a specific order make up a word, and a number of words is used to make a sentence. DOG bit

4. Computer Codes Computer (binary) code is another example. “32-bit” means that every computer “word” has 32 digits, all of which are 1s or 0s (on / off). Computers are just really fast calculators with special programs. 00000000000000000000000000000001 = 1 00000000000000000000000000000010 = 2 00000000000000000000000000000011 = 3 00000000000000000000000000000100 = 4 00000000000000000000000000000101 = 5 00000000000000000000000000000110 = 6 00000000000000000000000000000111 = 7

5. Programs Program (n): “a planned, coordinated group of activities, procedures, etc., often for a specific purpose.“ DNA is a programming code for cells!

6. There are 4 bases in DNA: A,T,G, & C Computers use a 2 “letter” code: 0 and 1 The English language is a “base 26” code – there are 26 possible values for each piece of information DNA is a “base 4” code – every “bit” of information is a single A, T, G, or C in the DNA sequence.

7. The 4 “letters” of DNA : Nucleotide Bases

8. Let’s take a Look

9. This is a map of chromosome #6. How many copies of chromosome 6 are in each of your cells?

10. Close Up of Chromosome #6 This is a single gene called GUSBL1. We’ll call it Gus for short.

11. What Does a Gene Look Like? A Coded Message of DNA!!! 1 ggagcgcgcc agagactggc gggcagctcc gcccgcggcc gggatgcact aggcaaagcc 61 agctgggctc ctgagtccgg tgggtacttg gagaacttat tacgtctagc tggaggattg 121 taaatgcacc aatcagcatg ctgtgtctag ctcaagattt tctccatccc cttattttgg 181 gccagtggct gtcattacat atgagaactc aagctccatg aggagatgtt tcattgtcaa 241 gagcagtcat gatggcctgc actccacaca atgcaacaga gtgaaggagc aggttctggt 301 tctttggtgt agtcctgaag cttcctaaga aagttcacat caggtgatgg ataggagcaa 361 ccctgtaaaa ccagccttag actatttttc aaacaggctg gtgaattacc agatctccgt 421 caagtgcagt aaccagttca agttggaagt gtgtcttttg aatgcagaaa acaaagtcgt 481 ggacaaccag gctgggaccc agggccagct gaaggtgctg ggtgccaacc tctggtggcc 541 gtacctgatg cacgaacacc ccgcctacct gtactcgtgg gaggatggtg attgctcaca 601 ccaaagcctt ggacccctcc cagcctgtga cctttgtgac caactccacc tacgcagcag 661 acaagggggc tctgtatgtg gatgtgatcc gtgtgaacag ctactactct tggtatcgca 721 actacgggca cctggagttg attcagctgc agctgcccgc ccagtttgag aattggtgta 781 agacatcaca atcccattat tcagagcgcg tatggagtgg aaacgcttat agggtttcac 841 caggatccac ctctgatgtt cagtgaagag taccagaaaa gtctgctaga gcagtaccat 901 ctgggtctgg atcaaaaacg cagaaaatac gtggttggag agctcatctg gaattttgcc 961 gatttcatga ctaaccagt

12. OK, but What IS it?

13. Each Nucleotide has 3 Parts

14. Complimentary Base-Pairing The 2 strands of a DNA molecule are held together by HYDROGEN BONDS between nucleotides Because they have different shapes, A and T stick together, as do G and C. A is always across from T and G is always across from C in a DNA molecule Practice…

15. What We’ve Learned About DNA Already: DNA is a chemical polymer made up of many subunits called… Nucleotides A gene (made of DNA) is a “program,” or instructions a cell uses to make a… Protein

16. Why Scientists Study DNA HEALTH: certain forms of genes can cause diseases, like cancer. Some genes can even predispose a person to diseases like alcoholism. BIOTECHNOLOGY: by manipulating the genetic program of organisms, many useful drugs and therapies have been developed (insulin, HgH, etc.). EVOLUTION: Changes in DNA sequences between species indicate how the sequences have changed over time. IDENTIFICATION: Every organism has a unique DNA sequence (exception: identical twins)

17. Think Quick! A scientist breaks a DNA molecule down into its individual subunits. These subunits are called: A. monosaccharides B. amino acids C. lipids D. nucleotides

18. The nucleotides from the last question are broken down even more. Which of the following will NOT be produced as a result? A. Phosphate B. Sugar C. Proteins D. Nitrogen Bases

19. HOMEWORK Read “The Structure of DNA” pp. 185-187 SR # 1-3 p. 189