1. Materials move through cells by diffusion. Oxygen and food move into cells, while waste products move out of cells. How does the size of a cell affect how efficiently materials get to all parts of a cell? Work with a partner to complete this activity 1. On a sheet of paper, make a drawing of a cell that has the following dimensions: 5 cm x 5 cm x 5 cm. Your partner should draw another cell about one half the size of your cell on a separate sheet of paper. 2. Compare your drawings. How much longer do you think it would take to get from the cell membrane to the center of the big cell than from the cell membrane to the center of the smaller cell? 3.What is the advantage of cells being small? It would take twice the amount of time. If cells are small, materials can be distributed to all parts of the cell quickly.

2. Image from: http://www.bcps.org/offices/lis/models/life/images/grow.JPG Image by Riedell CELL GROWTH & DIVISION 10-1 & 10-2

3. 10–1 Cell Growth A. Limits to Cell Growth 1.DNA “Overload” 2.Exchanging Materials 3.Ratio of Surface Area to Volume 4.Cell Division

4. 2 Reasons why cells divide 1. _____________________ As cell grows bigger demand on DNA “genetic library” becomes too great Ex: Small town library has 1000 books. As town grows and more people borrow books, there may be a waiting list to read the most popular titles DNA OVERLOAD http://www.adc.state.az.us/images/Off-Library.JPG

5. 2 Reasons why cells divide 2. _____________________ As cell grows bigger demand for transport across membrane is too great Material exchange can’t keep up http://www.animationlibrary.com

6. Ability to transport of oxygen, food, waste across cell membrane depends on _______________ Need for these depends on ___________ SURFACE AREA CELL VOLUME As cell grows these DON’T increase at the same rate

7. Go to Section: Cell Size Surface Area (length x width x 6) Volume (length x width x height) Ratio of Surface Area to Volume Ratio of Surface Area to Volume in Cells Section 10-1

8. BIGGER CELLS NEED MORE FOOD and OXYGEN, but CAN’T TRANSPORT IT FAST ENOUGH or IN BIG ENOUGH QUANTITIES! http://www.animationlibrary.com

9. Multicellular organisms grow mainly by increasing cell number Image from: http://www.bcps.org/offices/lis/models/life/images/grow.JPG Image by Riedell

10. Go to Section: Section Outline 10–2Cell Division A.Chromosomes B.The Cell Cycle C. Events of the Cell Cycle D. Mitosis 1.Prophase 2.Metaphase 3.Anaphase 4.Telophase E.Cytokinesis Section 10-2

11. SPREAD OUT IN NON-DIVIDING CELLS SCRUNCHED UP IN DIVIDING CELLS CHROMATIN CHROMOSOMES DNA CAN BE:

12. DNA in PROKARYOTES BACTERIAL DNA is CIRCULAR HAVE ONE CHROMOSOME NO NUCLEUS; ATTACHED TO CELL MEMBRANE http://www.origin-life.gr.jp/3202/3202121/fig6.jpg

13. DNA in EUKARYOTES (Plants & Animals) DNA is ROD-SHAPED CHROMOSOMES MANY PAIRS FOUND IN NUCLEUS http://cellbio.utmb.edu/cellbio/chrom2.jpg

14. Chromosome structure ___________________ 2 identical arms __________________ constricted area holds chromatids together __________________ PAIR 2 of each chromosome (one from mom; one from dad) CHROMATIDS CENTROMERE HOMOLOGOUS

15. HOMOLOGOUS CHROMOSOMES http://arnica.csustan.edu/biol3020/cell_division/cell_division.htm SAME SIZE SAME SHAPE CARRY GENES for the SAME TRAITS BUT ______________! (Don’t have to have the SAME CHOICES) http://sps.k12.ar.us/massengale/genetics%20tutorial.htm NOT IDENTICAL

16. CELL DIVISION in PROKARYOTES Bacteria reproduce using __________________________________ BINARY FISSION http://fig.cox.miami.edu/~cmallery/150/mitosis/fission.jpg

17. CELL DIVISION in EUKARYOTES is more complicated Division of nucleus (chromosomes)= _____________ Division of cytoplasm = ___________

18. ______________ = series of events that cells go through as they grow and develop cells alive cell cycle CELL CYCLE

19. INTERPHASE – non-dividing phase G 1 - Grow bigger Cell is “doing its job” DNA is spread out as chromatin S - Synthesis (copy DNA) & chromosomal proteins G 2 - Grow bigger, make organelles & molecules needed for cell division

20. CELL DIVISION MITOSIS – Nuclear division Prophase Metaphase Anaphase Telophase Cytokinesis – Cytoplasm divides G 0 – cell stops dividing (Ex: nerve cell)

21. Go to Section: M phase G 2 phase S phase G 1 phase Figure 10–4 The Cell Cycle Section 10-2

22. CELL DIVISION in EUKARYOTES is more complicated Division of nucleus (chromosomes)= _____________ Division of cytoplasm = ___________ MITOSIS CYTOKINESIS

25. INTERPHASE (G 1 - S - G 2 ) In between divisions Cells are in this phase most of the time Can see nucleus DNA spread out as chromatin Can’t see chromosomes DNA gets copied (S) Cell gets ready to divide

26. PROPHASE 1st dividing phase Spindle fibers form & attach to chromosomes Nuclear membrane & nucleolus disappear DNA scrunches into chromosomes Centrioles appear in centrosome region & move to poles Pearson Education Inc publishing as Pearson Prentice Hall http://www.life.uiuc.edu/plantbio/102/lectures/08mit&veg102.html

27. ________ region organizes spindle Spindle MICROTUBULES are part of cytoskeleton http://www.coleharbourhigh.ednet.ns.ca/library/organelle_worksheet.htm CENTROSOME

28. METAPHASE Chromosomes line up in ___________ middle Images from: Pearson Eduction Ince; Publishing as Pearson Prentice Hall http://www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0247.JPG

29. ANAPHASE Centromeres split Centrioles pull chromatids_______ apart Images from: Pearson Eduction Ince; Publishing as Pearson Prentice Hall http://www.science.siu.edu/plant-biology/PLB117/JPEGs%20CD/0247.JPG

30. TELOPHASE (reverse prophase steps) See ______ nuclei Nuclear membrane & nucleolus return Chromosomes spread out as chromatin Centrioles disappear Spindle fibers disappear two Images from: Pearson Eduction Ince; Publishing as Pearson Prentice Hall http://www2.bc.cc.ca.us/cnewton/Biology%2011/Mitosis.html

31. CYTOKINESIS Cytoplasm splits into 2 cells ANIMAL CELLS pinch cytoplasm in two with a ______________________ CLEAVAGE FURROW

32. CYTOKINESIS Cytoplasm splits into 2 cells PLANT CELLS can’t pinch because they have a sturdy ____________ Plant cells separate cytoplasm by growing a _______________ down the middle. CELL PLATE CELL WALL http://www.eastcentral.edu/acad/depts/BI/plant_mitosis_nolabels.html

33. Go to Section: Centrioles Chromatin Interphase Nuclear envelope Cytokinesis Nuclear envelope reforming Telophase Anaphase Individual chromosomes Metaphase Centriole Spindle Centriole Chromosomes (paired chromatids) Prophase Centromere Spindle forming Section 10-2 Figure 10–5 Mitosis and Cytokinesis

34. Go to Section: Centrioles Chromatin Interphase Nuclear envelope Cytokinesis Nuclear envelope reforming Telophase Anaphase Individual chromosomes Metaphase Centriole Spindle Centriole Chromosomes (paired chromatids) Prophase Centromere Spindle forming Section 10-2 Figure 10–5 Mitosis and Cytokinesis

35. Go to Section: Centrioles Chromatin Interphase Nuclear envelope Cytokinesis Nuclear envelope reforming Telophase Anaphase Individual chromosomes Metaphase Centriole Spindle Centriole Chromosomes (paired chromatids) Prophase Centromere Spindle forming Section 10-2 Figure 10–5 Mitosis and Cytokinesis

36. Go to Section: Centrioles Chromatin Interphase Nuclear envelope Cytokinesis Nuclear envelope reforming Telophase Anaphase Individual chromosomes Metaphase Centriole Spindle Centriole Chromosomes (paired chromatids) Prophase Centromere Spindle forming Section 10-2 Figure 10–5 Mitosis and Cytokinesis

37. Go to Section: Centrioles Chromatin Interphase Nuclear envelope Cytokinesis Nuclear envelope reforming Telophase Anaphase Individual chromosomes Metaphase Centriole Spindle Centriole Chromosomes (paired chromatids) Prophase Centromere Spindle forming Section 10-2 Figure 10–5 Mitosis and Cytokinesis

38. Go to Section: Centrioles Chromatin Interphase Nuclear envelope Cytokinesis Nuclear envelope reforming Telophase Anaphase Individual chromosomes Metaphase Centriole Spindle Centriole Chromosomes (paired chromatids) Prophase Centromere Spindle forming Section 10-2 Figure 10–5 Mitosis and Cytokinesis

39. Videos Animal Cell Mitosis Animal Cell Cytokinesis

40. Go to Section: includes is divided into Concept Map Section 10-2 Cell Cycle

41. Go to Section: includes is divided into Concept Map Section 10-2 Cell Cycle M phase (Mitosis) Interphase G 1 phaseS phaseProphaseG 2 phaseMetaphaseTelophaseAnaphase

42. SOUTH DAKOTA CORE SCIENCE STANDARDS 9-12.L.1.1. Students are able to relate cellular functions and processes to specialized structures within cells. Transport (ANALYSIS) cell membranes, homeostasis Cell life cycles (ANALYSIS) Examples: somatic cells (mitosis) LIFE SCIENCE: Indicator 1: Understand the fundamental structures, functions, classifications, and mechanisms found in living things

43. Core High School Life Science Performance Descriptors High school students performing at the ADVANCED level: predict the function of a given structure; predict the outcome of changes in the cell cycle; predict how homeostasis is maintained within living systems; High school students performing at the PROFICIENT level: describe the relationship between structure and function explain how homeostasis is maintained within living systems; compare and contrast the cell cycles in somatic and germ cells; High school students performing at the BASIC level recognize that different structures perform different functions define homeostasis; describe the life cycle of somatic cells;