1. © 2015 Intelligent Health How does physical activity work? Anti-inflammatoryAnti-aging

2. © 2015 Intelligent Health Telomeres get shorter Epel, Elissa, et al. Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres. Annals of the New York Academy of Sciences 1172.1 (2009): 34-53

3. © 2015 Intelligent Health Senescence: the end of the cell Hezel, Aram F., Nabeel Bardeesy and Richard S. Maser. ‘Telomere induced senescence: end game signaling.’ Current molecular medicine 5.2 (2005): 145-152.

4. © 2015 Intelligent Health This causes inflammation Immune system is constantly switched on

5. © 2015 Intelligent Health Inflammation: ‘the cause of causes’ Chronic Inflammation Starts in children as young as 6 years old Arthritis Cancers Diabetes Obesity Dementia Cardiovascular disease Anxiety and Depression

6. © 2015 Intelligent Health Loneliness Hostile Rejection People PlacePurpose Fear and Chronic Stress

7. © 2015 Intelligent Health Chronic Stress Stress Hormones Physical Inactivity And other poor health behaviours leads to inflammation Mitochondrial damage and telomere shortening Depression Mitochondria as a key component of the stress response. Manoli et al. Trends in Endocrinology and Metabolism Vol 18 No 5 2007 CancersDiabetesDementia Cardiovascular

8. © 2015 Intelligent Health We are designed to be active and eat a balanced diet

9. © 2015 Intelligent Health ‘Physical inactivity is the fourth leading cause of death worldwide.’

10. © 2015 Intelligent Health Mortality due to Inactivity Lee I-M et al. Effects of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. The Lancet 2012 Published online July 18. Population Attributable Fraction of mortality due to Inactivity (%)

11. © 2015 Intelligent Health Attributable fractions for all-cause deaths Blair S N Br J Sports Med 2009;43:1-2 Attributable fractions (%) for all-cause deaths in 40,842 (3,333 deaths) men and 12,943 (491 deaths) women in the Aerobics Center Longitudinal Study Attributable Fraction %

12. © 2015 Intelligent Health Increases articular thickness in joints

13. © 2015 Intelligent Health Increases Hippocampus by 20%

14. © 2015 Intelligent Health Reduces Breast Cancer recurrence by 24%

15. © 2015 Intelligent Health Boosts Natural Killer Cells

16. © 2015 Intelligent Health Physical Activity clears all CVD risk from patients with Diabetes Moe B et al Diabetes Care March 2013 vol. 36 no. 3 690-695 Follow up of 53,973 Norwegian Men (recruited 1995). Adjusted for weight, 1,750 deaths from CVD in 2008. Less than 3 hours vs more than 3 hours a week of Physical Activity CVD Risk (1.93 – 4.07) (0.48 – 1.63) (0.63 – 0.96)

17. © 2015 Intelligent Health Hazard Ratios (95% Confident Intervals) of incident Metabolic Syndrome Duck-chul Lee, Xuemei Sui, Timothy S. Church, Carl J. Lavie, Andrew S. Jackson, Steven N. Blair: Changes in Fitness and Fatness on the Development of Cardiovascular Disease Risk Factors: Hypertension, Metabolic Syndrome, and Hypercholesterolemia Journal of the American College of Cardiology – 14 February 2012 (Vol. 59, Issue 7, Pages 665-672

18. © 2015 Intelligent Health Physical Activity is more than just weight loss

19. © 2015 Intelligent Health Meet Bob

20. © 2015 Intelligent Health Let’s get Bob active

21. © 2015 Intelligent Health We can give him NHS treatment

22. © 2015 Intelligent Health ‘Bob, why don’t you get off the bus a stop early?’

23. © 2015 Intelligent Health ‘Bob, you really should take the stairs instead of the lift’

24. © 2015 Intelligent Health ‘Bob, why don’t you try Betty’s keep fit class on a Tuesday?’

25. © 2015 Intelligent Health ‘Bob, have you tried cycling to the shops?’

26. © 2015 Intelligent Health Or we can link him with a group of supporters who walk 2 miles to Anfield

27. © 2015 Intelligent Health and to Bob, that is not exercise or health

28. © 2015 Intelligent Health It is invisible to him It is a ‘means to an end’ not the end itself ‘The end’ is now getting to Anfield And finding this greater value for each person will help create the industrial scale required Physical Activity is now hidden behind a much greater experience for Bob

29. © 2015 Intelligent Health How many minutes of exercise did you do yesterday? How much time did you spend sitting yesterday?