1. Mouse ECG (Tech) NCRR Overview Technology for the “Mouse ECG” project CardioWave BioPSE project background Tools developed to date Tools for the next phase

2. Mouse ECG (Tech) NCRR CardioWave BioPSE Original Project Specification CardioWave software provides cardiac activation modeling: runs in parallel on a distributed memory machine. Interface with SCIRun, for SCIRun's modeling and visualization capabilities. Application steps: ­build a model based on DTI heart data ­visualize the fibers ­modify the model (e.g. ischemia) ­simulate activation [CardioWave] ­visualize the results (Vi, Ve, activation time) ­embed heart in an FEM torso model ­simulate volume conduction over time steps ­visualize torso surface potential maps and ECGs

3. Mouse ECG (Tech) NCRR CardioWave BioPSE (2)

4. Mouse ECG (Tech) NCRR CardioWave BioPSE (3) Required Technologies Modeling tools: ­region selection ­Morphological operators (flood fill, erosion/dilation) ­Teem's tensor utilities (eigen-decomposition) Simulation tools ­integrate Duke's "Vulcan" FVM code Visualization / Analysis tools ­spinning fibers ­time-dependent visualization ­synchronized viewers Infrastructure tools ­data import / export ­direct matlab file i/o ­sockets (control, data passing) ­annotations ­subnets ­data bundles

5. Mouse ECG (Tech) NCRR CardioWave BioPSE (4) Demonstration of the Latest Technical Developments and Direction…