1. MANAGEMENT OF ANAEMIA IN PATIENTS ON DIALYSIS Philip N. Jeremiah Bee Boon Cheak Ghazali B Ahmad Lim Soo Kun Zawawi B Nordin Source: 20 th MDTR Report 2012, NRR

2. Table 6.1.1: Treatment for anaemia, HD patients 1997-2012 Year Number of patients % on ESAs % received blood transfusion % on oral iron % received parenteral iron 19971695468924 199821414613924 199929965115905 200043905615885 200151946213885 200261086710857 200370177212838 2004806474118010 2005934481147411 20061167983187616 20071290785157417 20081539988166323 20091796889155926 20101950990145726 20112277790145428 20122589291145530 Source: 20 th MDTR Report 2012, NRR

3. Table 6.1.2: Treatment for anaemia, PD patients 1997-2012 Year Number of patients % on ESAs % received blood transfusion % on oral iron % received parenteral iron 19974763712963 19985414416963 19996104414940 20006624611924 20017814511912 20028914911932 200312305314874 200413126315857 200513907212878 2006155274168313 2007180674168012 2008208477167712 2009221276167414 2010236078167312 2011261278187110 2012293880186811 Source: 20 th MDTR Report 2012, NRR

4. Table 6.1.3: Variation in Erythropoiesis-Stimulating Agents (ESAs) utilization (% patients) among HD centres, 1997-2012 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997457203648617291 199850043650587886 1999747204251678290 200010502042566983100 200112701948617688100 2002152142857.570.57990100 2003183173960738394100 2004219114066778697100 2005243854748291100 2006289354798793100 2007322462828994100 20083803366859196100 2009425868869296100 20104591373869296100 2011513475879397100 20125633776889397100 Source: 20 th MDTR Report 2012, NRR

5. Figure 6.1.3(a): Variation in ESAs utilization (% patients) among HD centres, 2012 Source: 20 th MDTR Report 2012, NRR

6. Figure 6.1.3(b): Median of ESA utilisation (% patients) among HD centres, 1997-2012 Source: 20 th MDTR Report 2012, NRR

7. Table 6.1.4: Variation in ESAs utilization (% patients) among PD centres, 1997-2012 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997719 21414953 1998915 30465860 19991022 3240.55478 20001126 33475670 20011225 334757.587 20021526 43536371 20031825 3850.56892 2004185552637797 20051941 63698197 20062235526773.5869697 20072304464769097100 200824205970.57986100 2009253056738087100 20102655638083.595100 201128446578.58792.5100 2012295172808793100 Source: 20 th MDTR Report 2012, NRR

8. Figure 6.1.4(a): Variation in ESAs utilization (% patients) among PD centres, 2012 Source: 20 th MDTR Report 2012, NRR

9. Figure 6.1.4(b): Median of ESA utilisation (% patients) among PD centres, 1997-2012 Source: 20 th MDTR Report 2012, NRR

10. Table 6.1.5: Variation in mean weekly ESAs dose (u/week) among HD centres, 1997-2012 Year Number of centres MeanSDMin 5 th centile LQ Media n UQ 95 th centile Max 19972926576052000 21822438307138673941 19983225975862000 20712408313236673818 199955239046418002000 2154266734553643 200078245255417902000 2326261536674783 200195248262519602000 2267280038184857 2002118247171016922000 2230261540005667 2003146246362317902000 2174266737474769 2004179246364719292000 2182260938624929 2005219349718712000 226729294066640016000 20062715119209420002800385447005932812520571 20073055285185820003143405950446108813316706 2008361458311281938300038064476520065298632 200940247478882444337841344780524162838154 2010437509611202182342543855000571472738240 20114995169128820003417434050445810741412919 20125475287135020003500436251256000749013250 Source: 20 th MDTR Report 2012, NRR

11. Figure 6.1.5(a): Variation in mean weekly ESAs dose (u/week) among HD centres 2012 Source: 20 th MDTR Report 2012, NRR

12. Figure 6.1.5(b): Median of mean weekly ESAs dose (u/week) among HD centres, 1997-2012 Source: 20 th MDTR Report 2012, NRR

13. Table 6.1.6: Variation in mean weekly ESAs dose (u/week) among PD centres, 1997-2012 Year Number of centres MeanSDMin 5 th centile LQ Media n UQ 95 th centile Max 1997631065212563 2625307935003790 1998628263552516 2570266032313318 1999726463042320 2385263529333146 2000827574802267 2300272130753600 20011126004422000 2300246231303360 20021226005371857 2240244730503453 20031625943952059 2279256328883575 20041726034302074 2400260026963958 200518344215822000 2296267841247371 200621464911802308266740915028544159656373 200722497210153250342941825058570264717090 20082245409812556300038524481534460516239 20092343579262364266740614613480952416541 20102543919572364272740224273498360666429 201128450312751947195539184600504370007849 201228467110892519263641984653507162088077 Source: 20 th MDTR Report 2012, NRR

14. Figure 6.1.6(a): Variation in mean weekly ESAs dose (u/week) among PD centres 2012 Source: 20 th MDTR Report 2012, NRR

15. Figure 6.1.6(b): Median of mean weekly ESAs dose (u/week) among PD centres, 1997-2012 Source: 20 th MDTR Report 2012, NRR

16. Table 6.1.7: Variation in use of blood transfusion (% patients) among HD centres, 1997-2012 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997450006133771 1998500049153649 19997400211214255 200010500511204776 200112700512203650 2002152002714.52767 20031830048183363 20042190027173548 200524300510204275 2006289021118294689 2007321008142441100 2008380008162747.5100 2009424007142244100 2010458007132242100 201151300713213689 2012563007132143100 Source: 20 th MDTR Report 2012, NRR

17. Figure 6.1.7(a): Variation in use of blood transfusion (% patients) among HD centres, 2012 Source: 20 th MDTR Report 2012, NRR

18. Figure 6.1.7(b): Median of use of blood transfusion (% patients) among HD centres, 1997-2012 Source: 20 th MDTR Report 2012, NRR

19. Table 6.1.8: Variation in use of blood transfusion (% patients) among PD centres, 1997-2012 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997711462947 19989007111747 1999100006.52447 20001100081742 2001120003.51637 20021500582142 20031800310.52159 20041800614.52037 200519004111744 20062203917273647 200723671118243336 20082424816263640 20092500915253138 20102600915.5253450 2011283513192367100 20122903917303975 Source: 20 th MDTR Report 2012, NRR

20. Figure 6.1.8(a): Variation in use of blood transfusion (% patients) among PD centres, 2012 Source: 20 th MDTR Report 2012, NRR

21. Figure 6.1.8(b): Median of use of blood transfusion (% patients) among PD centres, 1997-2012 Source: 20 th MDTR Report 2012, NRR

22. Table 6.2.1: Distribution of serum ferritin without ESAs, HD patients 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients ≥100 ng/ml % Patients ≥200 ng/ml 1997280493.1349.3435.5162.5850.58671 1998224430.8383.2297.5128.4636.58063 1999337517.9424.3402.8162.8809.58668 2000571487.5416.8363.2152.57418367 2001758537.6453.9383.51728288771 2002803519.5447.3373168.57818571 2003916551.5434.2456.7190827.78774 20041042590.7463.6473.5218910.58977 20051010618.5498.7485.52259029077 20061169562.4485.6408193.8817.58774 20071182586501431196860.98675 20081186578489.9431.9197838.18775 20091283546.6461.7419.71717988771 20101387510454.2372159.7755.68469 20111582497.5439.93731637008470 20121679480.7441.4344146.1671.78367 Source: 20 th MDTR Report 2012, NRR

23. Figure 6.2.1: Cumulative Distribution of serum ferritin without ESAs, HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

24. Table 6.2.2: Distribution of serum ferritin without ESAs, PD patients 1997-2012 YearNumber of patientsMeanSDMedianLQUQ % Patients ≥100 ng/ml % Patients ≥200 ng/ml 1997133469333.53921987188874 199892492.4368.3405208.2687.58777 1999124553.7400.1499.3255.3686.89485 2000144505.9433.8420152.3675.58869 2001223543.8417.5440216.97549178 2002236634.8491.2514.9226924.69379 2003329602.5429.2503.72698349384 2004303608.4385.7522.73308829485 2005225651.4397.8609324913.39688 2006263589.9411.3484280815.89585 2007305636.9396.6582.3342.8841.99687 2008338634410.1592327.48419386 2009364621.6401.1553322.5861.89586 2010382624.9446.6523.5287.4875.89383 2011443600406.7499.4313.7796.89587 2012476558.2401.9457.2262.2743.59583 Source: 20 th MDTR Report 2012, NRR

25. Figure 6.2.2: Distribution of serum ferritin without ESAs, PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

26. Table 6.2.3: Distribution of serum ferritin on ESAs, HD patients 1997- 2012 Year Number of patients MeanSDMedianLQUQ % Patients ≥100 ng/ml % Patients ≥200 ng/ml 1997471543.3347495.52199739077 1998328549.9382.4476.5248809.89180 1999586560.4418.64532258299379 20001174588.3456.6475.52198609178 20011637597.5444.2491236894.29179 20022224593.1459.3464.8231.3878.29179 20033134640.8428.1563.32989319485 20043904669.7460.4571306976.59486 20055116682.7471599.5315.3971.59385 20066765640.3459543291.28819384 20078032658.8452.2564.4315.59149486 20089936703.6469.3611337.5979.69587 200912236679.3459.5596.1319.59429486 201013597679.4470581.83129589485 201116274648.2459.45462949069384 201218431623.8448.5524277.58739383 Source: 20 th MDTR Report 2012, NRR

27. Figure 6.2.3: Cumulative distribution of serum ferritin on ESAs, HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

28. Table 6.2.4: Distribution of serum ferritin on ESAs, PD patients 1997- 2012 Year Number of patients MeanSDMedianLQUQ % Patients ≥100 ng/ml % Patients ≥200 ng/ml 1997129550.8323.74962568629381 1998135611.2438.3524.7257839.59380 1999136604.8436.3540.6264.6870.19379 2000180608.2416.7560295.2846.39282 2001261645.9449.2557.5275.7885.49384 2002345666.8462.4538.5284999.59485 2003517689.9459.9589304993.29685 2004540728.8427.2655.6406.3986.79892 2005767732.9433.6659403.6997.59792 2006888729.9435.6638.4399.5986.29894 20071091741.3426.1652423.810159894 20081310758.4445.4668.6422.41030.39893 20091390759.5438.7689421.11017.59893 20101554753.3438677.1426.31005.59793 20111681732.8439.1655.1407.51003.89792 20121946709.6443.2640.9376.1956.59690 Source: 20 th MDTR Report 2012, NRR

29. Figure 6.2.4: Cumulative distribution of serum ferritin on ESAs, PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

30. Table 6.2.5: Distribution of transferrin saturation without ESAs, HD patients, 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients ≥20 % 199772334.116.629.822.740.484 199859933.316.229.522.141.782 199965432.916.329.920.942.478 200080032.716.928.620.941.478 200183636.918.532.523.945.884 200281136.518.93222.945.783 200392240.318.636.127.251.291 2004103141.218.137.528.550.192 2005110637.717.834.425.646.287 2006114936.216.932.924.744.287 2007120636.116.532.52543.787 2008121134.315.531.823.741.485 2009128234.315.931.424.140.885 2010144233.515.630.422.740.583 2011156832.414.729.722.938.385 2012185232.314.429.822.738.683 Source: 20 th MDTR Report 2012, NRR

31. Figure 6.2.5: Cumulative distribution of transferrin saturation without ESAs, HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

32. Table 6.2.6: Distribution of transferrin saturation without ESAs, PD patients, 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients ≥20 % 199724638.717.935.325.447.688 199818437.715.737.325.64785 199919437.716.236.625.94788 20002363818.534.32548.186 200127943.220.84027.856.789 200233242.719.138.128.354.592 200339745.219.741.231.458.193 200437944.518.241.630.955.598 200528740.616.237.829.448.295 200629940.517.437.927.347.395 200734840.317.936.627.548.292 200834938.217.834.326.244.491 200943938.418.236.126.445.787 201044138.317.835.125.945.389 201142436.815.833.226.545.590 201249835.615.733.824.943.985 Source: 20 th MDTR Report 2012, NRR

33. Figure 6.2.6: Cumulative distribution of transferrin saturation without ESAs, PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

34. Table 6.2.7: Distribution of transferrin saturation on ESAs, HD patients, 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients ≥20 % 199763635.917.331.424.243.387 199854934.915.53224.442.586 199970334.51631.623.24285 2000124734.916.730.4234484 2001163436.217.932.323.64584 2002199534.617.630.622.243.681 2003264139.618.435.926.648.890 2004326939.61736.127.848.193 2005480836.617.232.824.64587 2006638435.116.431.624.142.187 2007760434.715.431.624.441.688 2008953534.715.431.52441.687 2009118503415.430.923.840.586 201013761341530.924.140.287 20111629732.614.329.723.138.885 20121899631.713.529.222.937.585 Source: 20 th MDTR Report 2012, NRR

35. Figure 6.2.7: Cumulative distribution of transferrin saturation on ESAs, HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

36. Table 6.2.8: Distribution of transferrin saturation on ESAs, PD patients, 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients ≥20 % 199714742.219.735.6275991 199811139.413.838.528.847.494 199913738.9173726.148.386 200023938.918.73624.551.186 200129244.119.640.729.255.894 200236343.618.639.73054.394 200346044.617.840.431.755.796 200469744.718.740.830.854.596 200582043.519.339.129.453.795 200691641.617.53829.450.795 2007108039.317.635.326.947.392 2008126538.617.934.426.247.191 2009155039.117.335.426.947.592 2010162838.917.535.526.747.391 2011167936.515.534.125.444.888 2012193836.214.53426.643.890 Source: 20 th MDTR Report 2012, NRR

37. Figure 6.2.8: Cumulative distribution of transferrin saturation on ESAs, PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

38. Table 6.2.9(a): Variation in Medium serum ferritin among patients on ESAs, HD centres 1997-2012 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 199720169230.3405492.8616.9904.1999 199813205 432468.5567722.8 199922169189.5373.5424.1520.8890.1941 200041165235.5372.5575.36978421087.5 200149213.8222383.5506700.8886.51209.5 200269117.6185363.3459.5611.6828.81031 2003100152.5289.9460.8567706.4973.61787.5 200412399.5324.8454.8570722.89772000 20051621.6328.5468.5625.9734982.52000 20062061.5227410.3549.5691899.32000 200724378.3254.3427.3559.8680.7872.31405 200828092.2319.9477.8592.8721.49451402 200933989.1292453.5590722895.51532.3 201036737.3275438.5564.5725.8975.31188 201143527245413.6532.3680.2917.11171.5 201249710.1242.9382.5509660.2879.11334.5 Source: 20 th MDTR Report 2012, NRR

39. Figure 6.2.9(a): Variation in medium serum ferritin among patients on ESAs, HD centres 2012 Source: 20 th MDTR Report 2012, NRR

40. Table 6.2.9(b): Proportion of patients on ESAs with serum ferritin ≥100 ng/ml, HD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997207375879296.5100 19981375 909194100 19992270769296100 20004168738893100 20014971 889396100 2002696073889397100 20031005775.59196100 200412350859296100 20051626809196100 20062060749194100 200724336759196100 200828045829296100 200933944829195100 201036713799096100 20114351575899599100 201249710768895100 Source: 20 th MDTR Report 2012, NRR

41. Figure 6.2.9(a): Variation in medium serum ferritin among patients on ESAs, HD centres 2012 Source: 20 th MDTR Report 2012, NRR

42. Table 6.2.9(b): Proportion of patients on ESAs with serum ferritin ≥100 ng/ml, HD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997207375879296.5100 19981375 909194100 19992270769296100 20004168738893100 20014971 889396100 2002696073889397100 20031005775.59196100 200412350859296100 20051626809196100 20062060749194100 200724336759196100 200828045829296100 200933944829195100 201036713799096100 20114351575899599100 201249710768895100 Source: 20 th MDTR Report 2012, NRR

43. Figure 6.2.9(b): Variation in proportion of patients on ESAs with serum ferritin ≥ 100 ng/ml, HD centres 2012 Source: 20 th MDTR Report 2012, NRR

44. Table 6.2.9(c): Median transferrin saturation among patients on ESAs, HD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 19972522.625.729.332.636.268.569.2 19982221.422.82832.235.644.451.4 19992616.42125.931.43444.8 2000451622.627.931.436.844.157.5 2001532122.627.232.13548.176.1 20026213.520.526.129.43650.860.2 20039018.224.930.734.34155.669.8 200411322.727.23335.941.45266.8 200514717.325.129.132.337.549.769.7 200618113.724.128.131.435.945.481.3 200721717.62227.931.435.842.878.1 200825716.523.827.831.634.246.275.8 200930116.922.827.430.434.24179.1 201035016.622.527.63133.940.976.6 201142715.322.626.529.732.83960.5 201248115.522.626.128.731.937.479.7 Source: 20 th MDTR Report 2012, NRR

45. Figure 6.2.9(c): Variation in median transferring saturation among patients on ESAs HD centres, 2012 Source: 20 th MDTR Report 2012, NRR

46. Table 6.2.9(d): Proportion of patients on ESAs with transferrin saturation ≥ 20%, HD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 19972569 849093100 1998225764788897100 19992630598386.594100 2000452060778694100 2001535760758896100 2002622755698392100 20039045678492100 200411367739094100 20051494270839195100 20061822061819095100 20072182763839096100 20082591768828995100 20093083564808894100 20103542464818994100 20114322563798693100 20124862360788794100 Source: 20 th MDTR Report 2012, NRR

47. Figure 6.2.9(d): Variation in proportion of patients on ESAs with transferring saturation ≥ 20%, HD centres, 2012 Source: 20 th MDTR Report 2012, NRR

48. Table 6.2.10(a): Variation in medium serum ferritin among patients on ESAs, PD centres 1997-2012 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 19974377.5 404.8457.3530577.5 19984418.4 468.7534.3606.3663 19995302.8 343.4470491.5719.5 20005335 437.3593745773 20019285.8 508581617.5908 200210372.2 437.4477606.5826.5 200312304 454.5520716.1954.9 200413317 523.8610701.3860.3 200517338.5 557.2709.9800.9843 200619391.2 531621.4788.5968.4 200721290.3349.5589.6633716.3961.71048.6 200821329.7385494.3656.3801.8970.1991.5 200921329.4341.3578.8670.7784.99471166.5 201024266.5306573.4654750.7799827.5 201126203.1362.2585.5641.5783.8923.8958.7 201227158.3205.7471.1643.1735.9870.51038.5 Source: 20 th MDTR Report 2012, NRR

49. Figure 6.2.10(a): Variation in medium serum ferritin among patients on ESAs, PD centres 2012 Source: 20 th MDTR Report 2012, NRR

50. Table 6.2.10(b): Proportion of patients on ESAs with serum ferritin ≥100 ng/ml, PD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997484 88.593.597100 1998483 8997.5100 1999585 9295100 2000587 889197100 2001980 8694100 20021091 9294.5100 20031285 959698100 20041393 95100 20051786 9697100 20061995 98100 20072190919698100 20082188 9398100 20092185869598100 201024858895.59899100 20112684 9297100 2012276583919698100 Source: 20 th MDTR Report 2012, NRR

51. Figure 6.2.10(b): Variation in proportion of patients on ESAs with serum ferritin ≥ 100ng/ml, PD centres 2012 Source: 20 th MDTR Report 2012, NRR

52. Table 6.2.10(c): Median transferrin saturation among patients on ESAs, PD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997626.7 27.633.642.570.5 1998434.2 35.53741.646.2 1999624 27.233.639.442.4 2000623.1 26.736.337.652.5 2001828.4 31.936.947.579.8 2002930.5 36.538.640.360.4 20031331.9 35.841.547.564 20041729.1 3640.942.782.3 20051730.3 36.139.143.474.9 20061931.9 34.837.74275.8 20071926.1 29.437.746.383 20081925.3 31.534.243.481.2 2009222526.732.937.244.654.983.2 20102223.924.933.235.742.253.178.3 20112422.423.930.534.537.148.660.3 20122525.126.530.534.436.145.245.7 Source: 20 th MDTR Report 2012, NRR

53. Figure 6.2.10(c): Variation in median transferrin saturation among patients on ESAs, PD centres 2012 Source: 20 th MDTR Report 2012, NRR

54. Table 6.2.10(d): Proportion of patients on ESAs with transferring saturation ≥ 20%, PD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997670 8890.5100 1998481 8895.596.597 1999653 8487.594100 2000668 7490100 2001885 9293.595.597 2002978 929398100 20031390 9596100 20041788 9697100 20051788 9397100 20061983 939598100 20071974 889498100 20081965 919597100 20092270839294.597100 20102269758995100 201124596785.59497.5100 2012256372869497100 Source: 20 th MDTR Report 2012, NRR

55. Figure 6.2.10(d): Variation in proportion of patients on ESAs with transferrin saturation ≥ 20 %, PD centres 2012 Source: 20 th MDTR Report 2012, NRR

56. Table 6.3.1: Distribution of haemoglobin concentration without ESAs, HD patients 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 19978969.31.99810.569238 199811199.11.98.97.810.371218 199914009.11.98.97.810.370228 200017529.42.19.17.910.6672211 200118099.41.99.3810.6642610 200217959.62.19.48.110.9622513 200318019.72.19.58.311602515 2004192510.12.29.98.611.5532819 2005166710.52.310.38.912.1462925 2006176010.62.210.5912.1423226 2007175610.82.210.79.112.4402931 2008175110.82.310.89.112.6392932 2009184711.22.311.39.412.9332938 2010187511.22.211.49.612.930 40 2011209411.22.211.49.712.8303139 2012226311.42.211.71013253144 Source: 20 th MDTR Report 2012, NRR

57. Figure 6.3.1(a): Cumulative distribution of haemoglobin concentration without ESAs, HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

58. Figure 6.3.1(b): Mean of haemoglobin concentration without ESAs, HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

59. Table 6.3.2: Distribution of haemoglobin concentration without ESAs, PD patients 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 19972979.21.69.18.110.372244 19983019.31.89.28.110.368266 19993369.51.69.58.410.566277 20003419.81.79.78.710.958339 20014059.81.89.78.610.759329 2002434101.89.98.811543511 2003542101.79.98.911523810 200448110.41.610.39.411.4424315 200537510.81.610.89.911.8285220 200638710.91.610.91011.8255520 200743611.11.61110.212.1225127 200845011.11.711.110.212.1215128 200948811.11.811.110.112.2254728 201049511.11.711.19.912.2274627 201155511.11.611.11012.2254827 201257511.21.711.110.112.4244630 Source: 20 th MDTR Report 2012, NRR

60. Figure 6.3.2(a): Cumulative distribution of haemoglobin concentration without ESAs, PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

61. Figure 6.3.2(b): Mean of haemoglobin concentration without ESAs, PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

62. Table 6.3.3(a): Distribution of haemoglobin concentration on ESAs, diabetes HD patients 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 19971368.71.48.67.79.581172 199818891.48.97.910.174242 19993559.21.69.1810.271263 20006449.31.69.18.210.370255 20019339.31.59.38.210.370264 200212619.51.79.48.410.565287 200316679.61.59.68.610.662326 200421899.81.59.78.710.857358 20052890101.69.98.911523810 20064084101.69.98.91153389 2007465510.11.510.1911.1484210 2008588210.11.510.1911.2474310 2009733810.21.510.39.211.3444511 2010812410.31.510.49.311.4424711 2011930210.31.510.49.311.4414712 20121073410.31.510.39.311.3424711 Source: 20 th MDTR Report 2012, NRR

63. Figure 6.3.3(a)(i): Cumulative distribution of haemoglobin concentration on ESAs, diabetes HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

64. Figure 6.3.3(a)(ii): Mean of haemoglobin concentration on ESAs, diabetes HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

65. Table 6.3.3(b): Distribution of haemoglobin concentration on ESAs, non-diabetes HD patients 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 199763791.697.91075232 19987839.11.69.17.910.371272 199911489.11.59.18.110.271263 200016889.51.89.48.310.664315 200121169.51.69.58.410.663325 200225989.51.79.68.410.761327 200331169.61.79.68.510.760328 200436179.91.69.98.81153389 2005432810.11.610.18.911.2484012 2006533110.11.610.19.111.2474112 2007604110.31.610.49.311.4414613 2008715210.31.510.49.211.4414712 2009818910.31.510.59.311.4404812 2010896910.41.510.59.411.5384913 20111027810.31.510.59.411.4394912 20121172510.31.510.49.311.4395011 Source: 20 th MDTR Report 2012, NRR

66. Figure 6.3.3(b)(i): Cumulative distribution of haemoglobin concentration on ESAs, non-diabetes HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

67. Figure 6.3.3(b)(ii): Mean of haemoglobin concentration on ESAs, non- diabetes HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

68. Table 6.3.4(a): Distribution of haemoglobin concentration on ESAs, diabetes PD patients 1997-2012 Year Number of subject MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 1997449.11.59.18.29.980164 1998559.11.68.7810.271254 19996191.398.19.979201 2000639.51.39.68.610.463352 2001729.81.69.88.710.654388 2002899.51.39.48.710.465332 200315310.11.710.19.111.2484111 200422410.21.610.29.111.3464014 200526710.31.610.39.311.543 14 200633410.21.410.39.411.1434710 200745910.51.310.49.611.4375112 200862910.51.310.69.611.4335512 200965210.51.410.69.611.4355312 201062010.51.410.59.511.4375013 201159210.41.410.59.511.4365311 201266710.41.410.59.611.337549 Source: 20 th MDTR Report 2012, NRR

69. Figure 6.3.4(a)(i): Cumulative distribution of haemoglobin concentration on ESAs, diabetes PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

70. Figure 6.3.4(a)(ii): Mean of haemoglobin concentration on ESAs, diabetes PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

71. Table 6.3.4(b): Distribution of haemoglobin concentration on ESAs, non-diabetes PD patients 1997-2012 Year Number of subject MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 19971318.71.58.47.69.679192 199818391.68.881075196 199920191.78.97.910.371245 20002379.31.89.18.110.666277 20012739.21.69.28.110.468275 20023439.41.79.38.210.470246 20034869.61.69.68.410.663289 20045749.71.79.68.410.957349 20057039.81.79.78.611563311 20067849.91.69.98.811523810 200786010.21.710.3911.4444115 200894810.21.610.39.211.344 12 2009101210.21.610.39.211.444 12 2010118510.21.610.39.111.3444511 2011135010.11.510.29.111.246459 2012158310.31.510.39.211.3434611 Source: 20 th MDTR Report 2012, NRR

72. Figure 6.3.4(b)(i): Cumulative distribution of haemoglobin concentration on ESAs, non-diabetes PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

73. Figure 6.3.4(b)(ii): Mean of haemoglobin concentration on ESAs, non- diabetes PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

74. Table 6.3.5(a): Proportion in median haemoglobin level among patients on ESAs, HD centres 1997-2012 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 1997297.888.599.310.410.6 1998327.6 8.69.19.410.410.5 1999537.78.18.69.19.610.310.4 2000758.18.28.99.39.710.514.6 2001918.18.48.99.49.910.411 20021137.58.38.99.51010.711.6 20031417.98.59.19.61010.711.6 20041777.68.69.29.810.21111.3 20052168.38.89.59.910.411.111.8 20062687.78.89.59.910.511.412.6 20073038.69.19.810.210.611.212.2 20083568.199.810.210.711.412.1 20094008.59.19.910.310.811.312.2 20104378.19.39.910.410.911.412.1 20114998.29.19.910.410.811.412.7 20125497.99.19.810.410.811.312.3 Source: 20 th MDTR Report 2012, NRR

75. Figure 6.3.5(a): Variation in median haemoglobin level among patients on ESAs, HD centres 2012 Source: 20 th MDTR Report 2012, NRR

76. Table 6.3.5(b): Proportion of patients on ESAs with haemoglobin level > 10g/dL, HD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 199729001423296082 1998320015.527.539.55771 199953041427366061 200075002033436197 2001914102233476971 20021130132636476487 20031417122736486995 20041777173142577385 200521601833496178100 20062680213648638194 2007303132843566783100 20083560254356.56983100 200940042746587086.5100 2010437132846607387100 201149902848607288100 201254902446607084100 Source: 20 th MDTR Report 2012, NRR

77. Figure 6.3.5(b): Variation in proportion of patients on ESAs with haemoglobin level > 10g/dL, HD centres 2012 Source: 20 th MDTR Report 2012, NRR

78. Table 6.3.6(a): Proportion in Median haemoglobin level among patients on ESAs, PD centres 1997-2012 Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 199767.8 8.799.5 199867.9 8.38.99.39.5 199978.1 8.48.79.39.5 200088.2 8.99.19.39.8 200111999.29.49.69.8 2002128.6 9.19.39.59.9 2003168.4 9.39.51011.2 2004178.4 9.29.710.211.2 2005188.8 9.69.910.311 2006228.78.99.59.910.410.610.9 2007229.5 10.110.310.811.1 2008229.29.610.210.410.811.111.2 2009239.5 9.910.510.71111.2 2010259.39.510.110.510.711.211.3 2011288.69.11010.310.611 2012289.4 9.910.410.611.111.2 Source: 20 th MDTR Report 2012, NRR

79. Figure 6.3.6(a): Variation in median haemoglobin level among patients on ESAs, PD centres 2012 Source: 20 th MDTR Report 2012, NRR

80. Table 6.3.6(b): Proportion of patients on ESAs with haemoglobin level > 10g/dL, PD centres Year Number of centres Min 5 th centile LQMedianUQ 95 th centile Max 199760010193138 1998619 2025.52940 199977720253640 2000819 3036.53843 20011125 31384250 200212 253237.548 200316002835.55075 20041710 38435372 20051821 35475676 20062216204348587075 20072235365259.56372 20082232355660.5657589 20092333384861677276 20102536 5058657376 201128182349.559697780 201228363947.561688185 Source: 20 th MDTR Report 2012, NRR

81. Figure 6.3.6(b): Variation in proportion of patients on ESAs with haemoglobin level > 10g/dL, PD centres, 2012 Source: 20 th MDTR Report 2012, NRR

82. Table 6.3.7: Distribution of haemoglobin concentration on ESAs, HD patients 1997-2012 Year Number of patients MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 19977738.91.68.97.89.976222 19989719.11.69.17.910.271263 199915039.21.59.18.110.271263 200023329.41.79.48.310.565296 200130499.41.69.48.310.565305 200238599.51.79.58.410.762317 200347839.61.69.68.510.761327 200458069.81.69.98.810.954379 20057218101.6108.911.1503911 2006941510.11.610911.1504010 20071069610.21.510.39.111.344 12 20081302310.21.510.39.111.3444511 20091552710.31.510.49.211.4424711 20101709310.31.510.49.311.4404812 20112003010.31.510.49.311.4404812 20122287210.31.510.49.311.4404812 Source: 20 th MDTR Report 2012, NRR

83. Figure 6.3.7(a): Cumulative distribution of haemoglobin concentration on ESAs, HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

84. Figure 6.3.7(b): Mean of haemoglobin concentration on ESAs, HD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

85. Table 6.3.8: Distribution of haemoglobin concentration on ESAs, PD patients 1997-2012 Year Number of subject MeanSDMedianLQUQ % Patients <10g/dL % Patients 10-<12g/dL % Patients >=12g/dL 19971758.81.58.67.79.879183 199823891.68.8810.174215 199926291.68.97.910.273234 20003009.41.79.28.210.665296 20013459.31.69.48.210.565305 20024329.41.69.38.410.469265 20036399.71.79.68.610.8593110 20047989.81.79.88.611543610 20059709.91.79.98.811.1533611 20061118101.610.1911.150419 2007131910.31.610.49.311.4424513 2008157710.31.510.49.411.3394813 2009166410.31.510.49.311.4404812 2010180510.31.510.49.311.4424612 2011199510.21.510.39.211.3424711 2012229810.31.510.49.411.3414811 Source: 20 th MDTR Report 2012, NRR

86. Figure 6.3.8(a): Cumulative distribution of haemoglobin concentration on ESAs, PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR

87. Figure 6.3.8(b): Mean of haemoglobin concentration on ESAs, PD patients 1997-2012 Source: 20 th MDTR Report 2012, NRR