1. Familial Hypercholesterolaemia - My Family History By Kenneth Henthorn as told to Dermot Neely

2. Family History - KH KH TC 11.0 (mmol/L) Index Case 55 y

3. Family History - KH KH TC 11.0 (mmol/L) Index Case 55 y First degree relatives 1 in 2 chance Second degree relatives 1 in 4 chance

4. Family History - parents II I KH TC 11.0 (mmol/L) Index Case K B 55 y First degree relatives 1 in 2 chance Second degree relatives 1 in 4 chance †76y†75y

5. Family History - parents II I KH TC 11.0 (mmol/L) MI age 36 Index Case K B 55 y First degree relatives 1 in 2 chance Second degree relatives 1 in 4 chance †76y†75y

6. Family History - parents II I KH TC 11.0 (mmol/L) MI age 36 Index Case K B 55 y ?chol First degree relatives 1 in 2 chance †76y†75y

7. Family History - siblings II I KH TC 11.0 (mmol/L) MI age 36 Index Case K B E 55 y K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y First degree relatives 1 in 2 chance †76y†75y

8. Family History - siblings II I KH TC 11.0 (mmol/L) MI age 36 Index Case K B E 55 y TC >13 (mmol/L) K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y First degree relatives 1 in 2 chance †76y†75y

9. Family History - siblings II I KH TC 11.0 (mmol/L) MI age 36 Index Case K B E 55 y TC >13 (mmol/L) K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y First degree relatives 1 in 2 chance †76y†75y ?chol

10. Family History - siblings II I KH TC 11.0 (mmol/L) MI age 36 Index Case K B E 55 y TC >13 (mmol/L) ?chol K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y First degree relatives 1 in 2 chance †76y†75y TC 9.7 (mmol/L)

11. Family History - siblings II I KH TC 11.0 (mmol/L) MI age 36 ?chol Index Case K B E 55 y TC >13 (mmol/L) ?chol K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y First degree relatives 1 in 2 chance †76y†75y TC 9.7 (mmol/L)

12. Family History - siblings II I KH TC 11.0 (mmol/L) MI age 36 ?chol Index Case K B E 55 y TC >13 (mmol/L) TC 9.7 (mmol/L) ?chol K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y First degree relatives 1 in 2 chance †76y†75y

13. Family History - siblings II I KH TC 11.0 (mmol/L) MI age 36 ?chol Index Case K B E 55 y TC >13 (mmol/L) TC 9.7 (mmol/L) ?chol K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y †76y†75y First degree relatives 1 in 2 chance Second degree relatives 1 in 4 chance

14. II I KH ?chol Index Case K B E TC >13 (mmol/L) TC 9.7 (mmol/L) ?chol K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y III Family History – the children TC 13 TC 11.3 28 y25 y 22 y 13 y28 y25 y TC 4.1 TC 4.6 J J S H †76y†75y Second degree relatives 1 in 4 chance

15. II I KH ?chol Index Case K B E ?chol K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y III Family History – second degree TC 13 TC 11.3 28 y25 y 22 y 13 y TC >12 30 y TC 4 28 y TC 4.1 TC 4.6 J J S M D H †76y†75y

16. II I KH ?chol Index Case K B E ?chol K J R 54 y52 y50 y ?chol P J †4y†36 y 55 y III Family History – second degree TC 13 TC 11.3 28 y25 y 22 y 13 y TC >12 30 y TC 4 28 y TC 4.1 TC 4.6 J J S M D H G TC 4 29 y †76y†75y