1. Kode Biotech: Focussed on innovation Steve Henry, Founder and CEO – Kode Biotech Professor – AUT Centre for Kode Technology Innovation, School of Engineering Centre for Kode Technology Innovation

2. SUPREME NEW ZEALAND INNOVATOR A proven proprietary platform technology with the potential to have major impact in multiple pharmaceutical related areas

3. Idea, Invention, Innovation IDEA (concept) INVENTION (concept made real) INNOVATION (useful implementation of invention)

4. invention Innovation idea implementation

5. Traditional academic route

6. Innovation gate Idea (initially unconstrained) But then innovation gate the idea by conceptual product (design), market gap analysis, competition, competitive advantage, ability to scale manufacture, stability (storage/shipping), ease of formulation, COGS, value proposition, FTO (patentability), regulatory hurdles, potential to partner, etc

7. Innovation gate Then maybe it is an academia project

8. Kode™ Technology market sector Mission: Kode Biotech is a life science intellectual property company that exists to create stakeholder wealth through Kode™ Technology

9. Disperse in water and in one step can paint a new biological and non-biological coating onto any biological and/or non-biological surface. Kode™ nanotechnology functional paints

10. Meet the Kode molecules “nanotechnology functional paint”

11. Primary functional heads for FSL’s Carbohydrates, 1 – 100 (inc. HA, sialyl, etc) Labels – biotin, fluorophores, isotopes Peptides < 60 aa Metals Polymers Chelators Chemically reactive groups inc click, maleimide Enzyme substrates, inc sortase Anti-microbials inc antibiotics

12. Secondary functional heads – captured or secondarily conjugated Avidin Antibodies (IgG and IgM) Cells Proteins

13. Any non biological surfaces ( <10 secs)

14. FSL constructs are inkjet printable

15. And can capture cells to surfaces

17. Attachment to non-biological surfaces

18. Constraints on Kode constructs Disperse in water Biologically inert (except head) Spontaneously and stably insert into cell membranes and/or modify surfaces Not affect functionality or vitality other than that induced by the functional head

19. Kode™ is “multi-functional nano paint” that by simple contact can paint multiple new biological and/or non-biological coatings onto almost any surface Proven Technology > 50% granted IPR portfolio (25 families > 150 patents) 25 peer-reviewed journal publications Several products in market generating revenue Scale GMP manufacture in progress for therapeutic Multiple global University R&D licensees AUT Centre for Kode Technology Innovation www.kodecyte.comwww.kodecyte.com - the academic repository for Kode™ Technology

20. Kode™ Technology top current innovations

21. Licensee: Products: Blood diagnostic products Kode™ Technology is used to add blood markers onto red cells to create both quality control products (Securacell™) and diagnostic reagents (Abtectcell™ and Phenocell™). Kode™ Technology was used to paint “Asian” blood group markers on European blood cells to create a diagnostic that allows CSL to sell product into Asia also in 2016 distributed by 1. Existing Products

22. Licensee: Products: Research tools Kode™ Technology in the form of several research products is sold to researchers throughout the world to modify cells, viruses and surfaces for research use. https://www.sigmaaldrich.com/kode 2. Existing Products

23. Licensee: Products: Solid tumor therapy Kode™ Technology in the form of an injection (Alphaject) is in clinical development for the treatment of solid tumors in humans. Human trials are scheduled for December 2016 https://www.youtube.com/watch?v=pIiWgQRa66o http://www.agalimmune.com/index.php/about- us/news-events 3. Existing Product

24. Kode™ Technology top innovation opportunities

25. Licensee: Products: In collaborative development One aspect of Kode™ Technology has been licensed to target drugs to specific locations in the human body. Modified liposomal and particle delivery unlicensed 4. Existing Product Opportunity

26. Potential licensee: Products: Kode™ Technology has been established as able to apply hydrating and anti-microbial surfaces onto contact lens. A proof-of-concept R&D project is contracted with to progress this opportunity 5. Existing Product Opportunity Potential licensee: Products: Oral care (teeth). Kode™ Technology has been established as capable of coating teeth in seconds. Negotiations are in progress with for this opportunity

27. Potential licensees: & Products: Skin care/cosmetics Kode™ Technology has the potential to be used as a water based hydrating and anti- microbial cosmetic, and is potentially capable of preventing PM2.5 air pollutants from penetrating the skin. Discussions with, and. 6. Existing Product Opportunity

28. Untreated BandAid™ growing bacteria Kode treated BandAid™ remains sterile Potential licensee: Products: Anti-microbial dressings Kode™ Technology can be applied to dressing surfaces including BandAid™ products and will cause the surface to be self-sterilising for at least 24 hours. Discussions have been opened with and are pending further experimental data 7. Existing Product Opportunity

29. Potential licensees: & Products: Surgical implant coatings Kode™ Technology can be applied to any implant surface in less than 1 second including hip, knee, breast, tubing, surgical thread/wire, etc and will cause the surface to be self-sterilising for at least 24 hours. Discussions have been opened with and other parties and are pending further experimental data Kode coating (left) on a 316L implant Kode treated implant remains sterile Untreated implant growing bacteria 8. Existing Product Opportunity

30. Potential licensee: Products: Pollution capturing surfaces Kode™ Technology can be applied to surfaces and capture airpollutants. Discussions have been opened with and are pending further experimental data 9. Existing Product Opportunity

31. Licensees: KBM, Dextra (NZP), & Products: FSL construct suppliers The manufacture and supply of Kode™ constructs to licensees is protected by patents and incurs royalty payments 10. Existing Products Supplies

32. Total addressable market for Kode-based products (opportunities 1-10) > USD 175 b

33. Potential markets: Multiple Products: Kode™ Technology has already established proof-of-concept / prototypes products for the following (a)Inkjet printed diagnostic assay on paper (b)Modification of microsphere (c)Anti-counterfeiting overt and covert devices of pharmaceuticals (d)Wound care (e)Bar-coding of cells and viruses (f)Extended range of diagnostic products Future Addressable Markets (a) (c) (b) (c) (d) (f) (e)

34. Kode Biotech Flexible and a little bit different

35. Kode Biotech Engagement

36. Revenue and Relationships

37. A micro company with big … Recruiting for this role

38. potential …

40. Web resources www.kodecyte.com www.kodebiotech.com www.glycoNZ.com http://www.aut.ac.nz/kti https://nz.linkedin.com/in/kodebiotech https://en.wikipedia.org/wiki/Kodecyte Contact CEO - Steve Henry shenry@kodebiotech.comshenry@kodebiotech.com