1. Chapter 9 Circulatory system

2. ---Closed tubular system ---Blood circulatory or cardiovascular S ---Lymph vascular S

3. The cardiovascular S heart artery vein capillary

4. 1. Capillaries 1) LM: endothelium: basement membrane: pericyte: /flattened with processes /function: i. support ii. undifferentiated cell

6. endothelial cell: processes –microvilli-like, finger-liked vesicle /60-70nm, constitute about 25-35% of total volume /transendothelial channel function: transport large molecules and storage of membrane (for enlarge, enlongated, pore-formed and microvilli)

7. EM: classification ① Continuous capillary: ---Structural feature: endothelial cell: -more vesicles -tight junction basal lamina: complete ---Distribution: CT, MT, lung and CNS

8. ② Fenestrated capillary --- Structural feature: endothelial cell: -have fenestrae or pore (60- 80nm in D, with 4-6 nm diaphragm) basal lamina: complete ---Distribution: gastrointestinal tract, endocrine gland and renal glomerulus

9. ③ Sinusoid capillaries (enlarge capillary) ---Structural feature: endothelium: gap, pore basal lamina: incomplete or no (absent) ---Distribution: liver, spleen and bone marrow

11. 2. Artery ---large A: aorta, pulmonary trunk ---medium-sized A: all named A, the diameter > 1mm (radial A, ulnar A) ---small A: 300um<D<1mm

12. 1)Medium-sized A – muscular A ---Tunica intima endothelium subendothelial layer: CT -collagenous F -elastic F -smooth muscle internal elastic membrane: wave-liked, pink-colored band- elastin

13. ---Tunica media: thickest layer smooth muscle: 10-40 layers of, circularly elastic F: produced by SM collagenous F: produced by SM ---Tunica adventitia: LCT –with small BV-vasa vasorum, NF and LV external elastic M

15. 2) Large A: elastic A ---Structural features: a. Tunica intima is thick, and internal elastic M is not prominant b. Tunica media: consists of 40-70 layers of elastic membrane, CF and SM

16. Large A elastic M SM

17. 3) Small A: ---large SA: internal EM 3-4 layers SM no external M ---small SA: no internal M 1-2 layers SM

19. 2. Veins ---three type ---correspond with A except for LV ---three layers

20. ---structural features: a. larger diameter, thinner walls- collapsed b. no internal and external elastic membrane, so the boundaries between three tunica are not very clear c. contains more CT, less smooth M, SM are arranged in bundles d. vein valve: /infolding of tunica intima /semilunar-liked /prevent back flow of blood

22. 4. Heart ---atrium(right and left) ---ventricle (right and left)

23. The wall of heart E SE subendocardial layer endocardium myocardium epicardium

24. 1) The wall of heart ---endocardium: endothelium subendothelial layer: more dense CT- contain fibroblast, CF, EF, SM subendocardial layer: LCT, with BV, N and conducting S- Purkinje fiber

25. ---myocardium: cardiac M: a. atrial muscle: /atrial granules: 0.3-0.4um in D, contain atrial natriuretic polypeptide or cardionatrin b. ventricular M: thick, long, branches LCT: rich in capillaries *atrioventricular fibrous annulus: DCT

26. ---epicardium: visceral layer of pericardium- serous membrane: mesothelium LCT: more fat cell- subepicardial layer ---cardiac valve: formed by infolding of endocardium: endothelium + DCT prevent the back flow of blood

27. 2) Conducting S ① components: ---sinoatriol node (SA node): located in epicardium of right atrium ---atrioventricular node (AV node) and bundles (AV bundles): located in subendocardial layer ---network of Purkinje fiber:

28. ② three types of cells a. pacemaker cell ( P cell): mainly distributed in SA and AV node small, fusiform or polygonal in shaped enclosed by DCT less organelle: myofibril, plasmalemmal vesicles and more glycogen

29. b. transitional cell: mainly distributed in periphery of SAN or AVN and AV bundle The structure is between pacemaker cell and cardiac M thinner and shorter than CM more myofibril than P cell

30. c. Purkinje cell: mainly constitute AV bundle and branches shorter, boarder than CM, with 1-2 centrally located nuclei rich in mitochondria, glycogen, less myofibril well-developed intercalated disks

31. Chapter 10 Immune system Chapter 10 Immune system

32. 1. Components 1) Cells

33. ① Lymphocyte : a. T-lymphocytes: cytotoxic T cell: Tc C- kill the tumor cell, virus infective cell and foreign cell helper T cell: Th C- promotes activity of BLC and Tc C suppressor T cell: Ts C –regulate the function of BLC and TC b. B-lymphocytes: become into plasma cell c. NK cell: counteract virus infective cell and tumor cell

34. ② Plasma cell ③ antigen presenting cell: a. dendritic cell: Blood DC Langerhans cell interstitial cell veiled cell interdigitating cell b.macrophage: Mononuclear phagocytic system

35. ④ other cells: granulated cell mast cell blood platelet blood-borne stem cell *Function: i. immunologic defence function ii. immune surveillance function iii. immune homeostasis

36. 2) Lymphoid tissue ---reticular T: reticular cell: stellate- shaped with processes to form network reticular fiber ---lymphocytes, macrophage, plasma cell and mast cell

37. a. Diffuse LT: no clear boundary mainly consists of TLC postcapillary venules: -high endothelial venules -opening for LC enter LT from blood

38. b. Lymphoid nodule: spherical or ovoid have clear boundaries mainly composed of BLC germinal center: stained pale * primary LN → secondary LN

39. 3) Lymphoid organs a.Central lymphoid organs: thymus, bone marrow developed earlier blood-borne stem cell comes from yolk sac microenvironment → proliferation promoting send LC to PLD and LT two weeks before borne

40. b. Peripheral lymphoid organs: lymph node, spleen and palatine tonsil developed later LC come from CLO cell proliferation need antigen stimulating - antigen dependent place for immune reactions

42. Thanks!