1. TRRM 2005/6 Introduction to TRRM Teaching Registrars Research Methods Jim teWaterNaude UCT Dept Public Health

2. TRRM 2005/6 Aims of the course n To enable registrars to acquire skills for designing clinical research n To enable registrars to produce their own research suitable for an MMed n To enable registrars to read articles critically, especially the methods section n To increase the research output of Health Sciences

3. TRRM 2005/6 How to get busy registrars to complete this course n Departmental & Faculty commitment n Mentor, research question, literature review n User-friendly text: Designing Clinical Research n Weekly written feedback from convenor n Set up small groups, or pairing up n Valuable product - the 5-page protocol n Promise of an MMed

4. TRRM 2005/6 Designing Clinical Research (content of a UCSF course) n - Research question and background n - Study designs and causal inference n - Subjects and variables n - Hypotheses and sample size n Create a 5-page protocol The UCT course is very similar …

5. TRRM 2005/6 TRRM (content of this 11 lecture UCT course) n - Research question (1) & Literature review (2) n - Study design (3) n - Population, sampling, measurement (4 & 5) n - Hypotheses and sample size (8 – 10) n - Ethics (11) n Create a 5-page protocol Evidence Based Medicine (6 & 7)

6. DateTitle Lecturer 26 August 2005The research planJim teWaterNaude 30 September 2005 Literature ReviewJimmy Volmink 28 October 2005 Study designLandon Myer 25 November 2005 Population and samplingRodney Ehrlich 27 January 2006 Measurement and quality controlRodney Ehrlich 24 February 2006 Evidence Based MedicineJames Irlam 31 March 2006Critical AppraisalJames Irlam 28 April 2006Data entry & exploratory analysisRauf Sayed 26 May 2006Hypothesis testing & confidence intervalsRauf Sayed 30 June 2006Sample sizeRauf Sayed 28 July 2006Research ethics Rodney Ehrlich & Tuviah Zabow Course timetable

7. TRRM 2005/6 Fridays are course days n Dr te Water Naude (course convenor) will be available on Fridays for the purposes of the course n Office on 4 th floor, Public Health Dept (may move to UCT Lung Institute) n Email is jim@cormack.uct.ac.za

8. TRRM 2005/6 The course is intended to be paperless n Registration is by email – send an email to jim@cormack.uct.ac.za n An E-list will be set up - replies to the list go centrally only - feedback may be individual or to the group - A Friday digest is intended n A CD will come out in October/ November – this will contain all the course material n There is a recommended textbook…

9. TRRM 2005/6

10. Designing Clinical Research 2nd Ed. Hulley et al Lippincott, Williams & Wilkins 2001 ISBN 0-7817-2218-7 Available to order on the web www.amazon.com Van Schaik have been asked to order

11. TRRM 2005/6 Good luck! Jim teWaterNaude UCT Dept Public Health