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Parameters for Lithium Treatment Are Critical in Its Enhancement of Fracture-Healing in Rodents by Joshua Bernick, Yufa Wang, Ian A. Sigal, Benjamin A.

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Presentation on theme: "Parameters for Lithium Treatment Are Critical in Its Enhancement of Fracture-Healing in Rodents by Joshua Bernick, Yufa Wang, Ian A. Sigal, Benjamin A."— Presentation transcript:

1 Parameters for Lithium Treatment Are Critical in Its Enhancement of Fracture-Healing in Rodents by Joshua Bernick, Yufa Wang, Ian A. Sigal, Benjamin A. Alman, Cari M. Whyne, and Diane Nam J Bone Joint Surg Am Volume 96(23):1990-1998 December 3, 2014 ©2014 by The Journal of Bone and Joint Surgery, Inc.

2 Diagram showing the high, middle, and low factor levels for lithium dosing, treatment-onset, and treatment-duration parameters explored in this study. Joshua Bernick et al. J Bone Joint Surg Am 2014;96:1990- 1998 ©2014 by The Journal of Bone and Joint Surgery, Inc.

3 A flowchart highlighting the chronology of the experimental procedures and analysis performed on each sample. μCT = microcomputed tomography, PMMA = polymethylmethacrylate, DICOMs = Digital Imaging and Communications in Medicine images, ROI = region of inte... Joshua Bernick et al. J Bone Joint Surg Am 2014;96:1990- 1998 ©2014 by The Journal of Bone and Joint Surgery, Inc.

4 Illustration showing the region of interest used in the stereological analysis. Joshua Bernick et al. J Bone Joint Surg Am 2014;96:1990- 1998 ©2014 by The Journal of Bone and Joint Surgery, Inc.

5 A Pareto chart showing both the size and direction of each input parameter as related to the output response. Joshua Bernick et al. J Bone Joint Surg Am 2014;96:1990- 1998 ©2014 by The Journal of Bone and Joint Surgery, Inc.

6 The predicted design space for maximum yield torque based on the design-of-experiments analysis. Joshua Bernick et al. J Bone Joint Surg Am 2014;96:1990- 1998 ©2014 by The Journal of Bone and Joint Surgery, Inc.

7 Figs. 6-A, 6-B, and 6-C Three-dimensional isosurface models and microcomputed tomography image slices of three rat femora used in the study at twenty-eight days after fracture. Joshua Bernick et al. J Bone Joint Surg Am 2014;96:1990- 1998 ©2014 by The Journal of Bone and Joint Surgery, Inc.

8 Lithium’s mechanism of action as it relates to glycogen synthase kinase (GSK)-3β. Joshua Bernick et al. J Bone Joint Surg Am 2014;96:1990- 1998 ©2014 by The Journal of Bone and Joint Surgery, Inc.

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