1. 945-5 Alzheimer’s Disease

2. Neuroimaging Figure 1 Sagittal T1WI in another case shows striking enlargement of the sylvian fissure and frontal sulci in a patient with advanced AD

3. Neuroimaging Figure 2 Axial FLAIR scan in the same case shows the markedly enlarged sylvian fissures. Note the underlying white matter is normal without evidence for the scattered hyperintense foci of microvascular disease

4. Neuroimaging Case 2. Heidenhain variant of AD is shown in this case. Note remarkable enlargement of the occipital horns with relative sparing of the temporal horns seen on te axial T1WI (A) and T2WI (B). The occipital cortex is thinned and atrophic (B, arrows).

5. Neuroimaging – Heidenhain Variant of AD Figure 3 Axial T1WI in a patient with the Heidenhain variant of AD shows disproportionate enlargement of the occipital horns of the lateral ventricles together with striking enlargement of the occipital sulci

6. Neuroimaging – Heidenhain Variant of AD Figure 4 Axial T2WI in the same case shows the cortex of the occipital gyri is markedly thinned. High signal intensity in the remaining parenchymal of the occipital lobes is also characteristic for the Heidenhain variant of AD

7. Acknowledgements Neuroimaging studies, Figure 1 – 4. Courtesy of Anne Osborn, M.D

8. http://library.med.utah.edu/NOVEL