1. Macromolecules

2. Organic Compounds CompoundsCARBON organicCompounds that contain CARBON are called organic. Macromoleculesorganic moleculesMacromolecules are large organic molecules.

3. Carbon (C) Carbon4 electronsCarbon has 4 electrons in outer shell. Carboncovalent bonds 4Carbon can form covalent bonds with as many as 4 other atoms (elements). Carbon is versatile C, H, O or NUsually with C, H, O or N. Example:CH 4 (methane)Example:CH 4 (methane)

4. Macromolecules Large organic molecules.Large organic molecules. POLYMERSAlso called POLYMERS. MONOMERSMade up of smaller “building blocks” called MONOMERS. Examples:Examples: 1. Carbohydrates 2. Lipids 3. Proteins 4. Nucleic acids (DNA and RNA)

5. Question: How Are Macromolecules Formed?

6. Answer: Dehydration Synthesis “condensation reaction”Also called “condensation reaction” polymers monomers“removing water.”Forms polymers by combining monomers by “removing water.” HOH HH H2OH2O

7. Question: How are Macromolecules separated or digested?

8. Answer: Hydrolysis monomers“adding water.”Separates monomers by “adding water.” HO HH H H2OH2O

9. Carbohydrates

10. Carbohydrates Small sugar moleculeslarge sugar moleculesSmall sugar molecules to large sugar molecules. Examples:Examples: A.monosaccharide B.disaccharide C.polysaccharide

11. Carbohydrates Monosaccharide: one sugar unit Examples:glucose ( Examples:glucose (C 6 H 12 O 6 )deoxyriboseribosefructosegalactose glucose

12. Carbohydrates Disaccharide: two sugar unit Examples: –Sucrose (glucose+fructose) –Lactose (glucose+galactose) –Maltose (glucose+glucose) glucoseglucose

13. Carbohydrates Polysaccharide: many sugar units Examples:starch (bread, potatoes) glycogen (beef muscle) cellulose (lettuce, corn) glucoseglucose glucoseglucose glucoseglucose glucoseglucose cellulose

14. Carbohydrates Function: short term energy storageFunction: short term energy storage Function: structure (cell walls and exoskeletons)Function: structure (cell walls and exoskeletons) copyright cmassengale14

15. Lipids

16. Lipids not soluble in waterGeneral term for compounds which are not soluble in water. are soluble in hydrophobic solventsLipids are soluble in hydrophobic solvents. Remember:“stores the most energy.”Remember: “stores the most energy.” Examples:1. FatsExamples:1. Fats 2. Phospholipids 3. Oils 4. Waxes 5. Steroid hormones 6. Triglycerides

17. Lipids Six functions of lipids: 1.Long term energy storage 2.Protection against heat loss (insulation) 3.Protection against physical shock 4.Protection against water loss 5.Chemical messengers (hormones) 6.Major component of membranes (phospholipids)

18. Lipids Triglycerides: c1 glycerol3 fatty acids Triglycerides: composed of 1 glycerol and 3 fatty acids. H H-C----O H glycerol O C-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 3 = fatty acids O C-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 3 = O C-CH 2 -CH 2 -CH 2 -CH =CH-CH 2 -CH 2 -CH 2 -CH 2 -CH 3 =

19. Fatty Acids fatty acids There are two kinds of fatty acids you may see these on food labels: 1.Saturated fatty acids: no double bonds (bad) 2.Unsaturated fatty acids: double bonds (good) O C-CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 2 -CH 3 = saturated O C-CH 2 -CH 2 -CH 2 -CH =CH-CH 2 -CH 2 -CH 2 -CH 2 -CH 3 = unsaturated

20. Proteins

21. Proteins (Polypeptides) peptide bonds polypeptidesAmino acids (20 different kinds of aa) bonded together by peptide bonds (polypeptides). Six functions of proteins:Six functions of proteins: 1.Storage:albumin (egg white) 2.Transport: hemoglobin 3.Regulatory:hormones 4.Movement:muscles 5.Structural:membranes, hair, nails 6.Enzymes:cellular reactions

22. Proteins (Polypeptides) Four levels of protein structure: A.Primary Structure B.Secondary Structure C.Tertiary Structure D.Quaternary Structure

23. Primary Structure peptide bonds (straight chains) Amino acids bonded together by peptide bonds (straight chains) aa1aa2aa3aa4aa5aa6 Peptide Bonds Amino Acids (aa)

24. Secondary Structure primary structurecoilspleats hydrogen bonds3-dimensional folding arrangement of a primary structure into coils and pleats held together by hydrogen bonds. Two examples:Two examples: Alpha Helix Beta Pleated Sheet Hydrogen Bonds

25. Tertiary Structure Secondary structuresbentfolded more complex 3-D arrangementSecondary structures bent and folded into a more complex 3-D arrangement of linked polypeptides Bonds: H-bonds, ionic, disulfide bridges (S-S)Bonds: H-bonds, ionic, disulfide bridges (S-S) “subunit”.Call a “subunit”. Alpha Helix Beta Pleated Sheet

26. Quaternary Structure Composed of 2 or more “subunits” Globular in shape Form in Aqueous environments enzymes (hemoglobin)Example: enzymes (hemoglobin) subunits

27. Nucleic Acids

28. Two types:Two types: a. Deoxyribonucleic acid (DNA-double helix) Function: DNA is the code from which all protein is synthesized. b. Ribonucleic acid (RNA-single strand) b. Ribonucleic acid (RNA-single strand) Function: Many functions—mRNA, tRNA, and rRNA (you will learn about these later). Nucleic acids nucleotidesdehydration synthesisNucleic acids are composed of long chains of nucleotides linked by dehydration synthesis.

29. Nucleic Acids Nucleotides include:Nucleotides include: phosphate group pentose sugar (5-carbon) nitrogenous bases: adenine (A) thymine (T) DNA only uracil (U) RNA only cytosine (C) guanine (G)

30. Nucleotide O O=P-O OPhosphate Group Group N Nitrogenous base (A, G, C, or T) (A, G, C, or T) CH2 O C1C1 C4C4 C3C3 C2C2 5 Sugar Sugar(deoxyribose)

31. DNA - double helix P P P O O O 1 2 3 4 5 5 3 3 5 P P P O O O 1 2 3 4 5 5 3 5 3 G C TA