1. High Concentrations of AGE-LDL and Oxidized LDL in Circulating Immune Complexes Are Associated With Progression of Retinopathy in Type 1 Diabetes Featured Article: Maria F. Lopes-Virella, M.D., Ph.D., Nathaniel L. Baker, M.S., Kelly J. Hunt, Ph.D., Timothy J. Lyons, M.D., Alicia J. Jenkins, M.D., Gabriel Virella, M.D., Ph.D., The DCCT/EDIC Study Group* Diabetes Care Volume 35: 1333-1340 June, 2012

2. Study Objectives Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340 To determine whether immunocomplexes (ICs) containing advanced glycation end product –LDL (AGE-LDL) and oxidized LDL (oxLDL) contribute to the development of retinopathy over a 16-year period in subjects with type 1 diabetes

3. Study Design Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340 517 participants in the DCCT/EDIC cohort Levels of AGE-LDL and oxLDL in ICs measured Retinopathy assessed by stereoscopic fundus photography Cox proportional hazards models used to assess effect of AGE-LDL-ICs and oxLDL-ICs on retinopathy progression

4. Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340

7. Conclusions Increased levels of AGE-LDL and oxLDL in ICs are associated with increased risk for progression to advanced retinopathy in patients with type 1 diabetes Suggests that the antibody response to modified LDL plays a significant role in retinopathy progression Lopes-Virella M et al. Diabetes Care 2012;35:1333-1340