1. Cardiovascular system
SYLLABUS:
RBP(Robbins Basic Pathology) Chapters:
The Blood Vessels
The Heart ,

2. Cardiovascular system
Postinflammatory valve scarring (rheumatic heart disease)
Giant cell myocarditis
Lymphocytic myocarditis
176a Cavernous hemangioma
Atherosclerosis
Arterio- and arteriolosclerosis (kidney)

3. obliterated originally layered and avascular leaflet architecture
Postinflammatory valve scarring (rheumatic heart disease)
diffuse fibrosis
neovascularization
obliterated originally layered and avascular leaflet architecture
Aschoff bodies replaced by fibrous scar

4. Postinflammatory valve scarring (rheumatic heart disease)

5. Postinflammatory valve scarring (rheumatic heart disease)

6. inflammatory cellular infiltrate containing:
Giant cell myocarditis
inflammatory cellular infiltrate containing:
- multinucleate giant cells (of either macrophage or myocyte origin)
lymphocytes
eosinophils
plasma cells
focal or frequently extensive necrosis

7. Giant cell myocarditis

8. Giant cell myocarditis

9. lymphocytic interstitial inflammatory infiltrate
Lymphocytic myocarditis
lymphocytic interstitial inflammatory infiltrate
focal necrosis of myocytes adjacent to the inflammatory cells

10. Lymphocytic myocarditis

11. sharply defined, but not encapsulated tumor
Cavernous hemangioma
sharply defined, but not encapsulated tumor
cavernous vascular spaces, partly or completely filled with blood separated by a scant connective tissue stroma
common intravascular thrombosis with associated dystrophic calcification

12. Cavernous hemangioma

13. Cavernous hemangioma

14. Atherosclerosis
the superficial fibrous cap composed of SMCs and relatively dense ECM
- beneath and to the side of the cap (the "shoulder") a cellular area consisting of macrophages, SMCs, and T lymphocytes
- necrotic core, containing a disorganized mass of lipid (primarily cholesterol and cholesterol esters), cholesterol clefts, debris from dead cells, foam cells (lipid-laden macrophages or SMCs), fibrin, variably organized thrombus, and other plasma proteins
- around the periphery of the lesions, there is usually evidence of neovascularization (proliferating small blood vessels)

15. Atherosclerosis

16. Arterio- and arteriolosclerosis (kidney)
Hyaline Arteriolosclerosis - homogeneous, pink, hyaline thickening of the walls of arterioles with loss of underlying structural detail, and with narrowing of the lumen
Hyperplastic arteriolosclerosis - onionskin, concentric, laminated thickening of the walls of arterioles with progressive narrowing of the lumina
- in malignant hypertension hyperplastic changes are accompanied by deposits of fibrinoid and acute necrosis of the vessel walls

17. Arterio- and arteriolosclerosis (kidney)

18. Arterio- and arteriolosclerosis (kidney)