1. NCI’s Physical Sciences – Oncology Centers Program: Evaluating trans-Disciplinary Collaborations and Field Convergence November 4, 2011 Larry A. Nagahara, PhD, Director, OPSO Nicole Moore, ScD, Project Manager, OPSO Office of Physical Sciences - Oncology, Center for Strategic Scientific Initiatives (CSSI), National Cancer Institute (NCI), National Institutes of Health (NIH)

2. Physical Scientist & Cancer Biologist How can I culture Physical Scientists & Cancer Biologists to work together? “helped many physicists make the transition to biology” They encouraged other investigators in the field to concentrate on seven bacteriophages... That way, experimental results from different laboratories could be compared. Max Delbrück

3. PS-OC Program Goal and Vision The Specific Purpose for the PS-OC Initiative: new knowledgenew fields of study To generate new knowledge and catalyze new fields of study in cancer research by utilizing physical sciences/engineering principles to enable a better understanding of cancer and its behavior at all scales. paradigm-shifting Not looking for new tools to do “better” science, but new perspectives and approaches to do paradigm-shifting science that will lead to exponential progress against cancer. trans-disciplinary teams Build trans-disciplinary teams and infrastructure to better understand and control cancer through the convergence of physical sciences and cancer biology. New – “Schools of Thought”

4. Scripps USC UC Berkeley Princeton DFCI TMHRI Moffitt ASU MIT Johns Hopkins Northwestern Cornell O’Halloran Licht Liphardt WeaverShuler Hempstead van Oudenaarden Jacks Michor Holland Austin Tlsty Wirtz SemenzaGatenby GilliesFerrari CurleyDavies Grady Kuhn Bethel Hillis Agus PS-OC Network: Physical scientists & cancer biologists/oncologists integrated at the start PS-OC Network

5. PS-OC Mechanism U54 (Cooperative Agreement Specialized Center) Facilitate and enable the convergence of the physical sciences with cancer biology/clinical oncology to understand cancer at a fundamental level. Active coordination by program managers trained in physical and cancer sciences. Accelerate ‘cycle of learning’ through shared resource core facilities. Provide linkages to key NCI programs and resources

6. PS-OC Operation: Interactions Inside and Outside of Network External Research Communities PS-OC Core A Education and Training Unit Outreach and Dissem Unit Project 2 Project 3 Project 4 Trans-Network Admin Unit Pilot Projects Organizing Framework Project 1 Core B PS-OC Core A Education and Training Unit Outreach and Dissem Unit Trans-Network Admin Unit Pilot Projects Organizing Framework Project 2 Project 3 Project 4 Project 1 Core B Trans- Network Projects Trainee Exchange Outreach Projects PS-OC Network Outreach Projects

7. Prospective Evaluation of PS-OCs Goal: Collect data during the Program for ongoing monitoring and feedback  Are the Program’s objectives and priorities being met by progress to date? Bring physical scientists to cancer research Form trans-disciplinary teams Convergence of Physical Sciences and Oncology fields Paradigm shifting science  What aspects of the Program should be changed?  Does the potential for future progress merit continued investment by NCI in the PS-OCs? Unique Program Unique Evaluation

8. Data Collection of Network Semi-Annual ~70-80 pages 3 reports to date Data Collection Methods: 1.Interviews with Investigators prior to start of program 2.Progress Reports  Progress of research towards aims  All personnel list  Publications, Presentations, Patents  List of trainees (including discipline)  Student exchanges and transitions  New collaborations within Center, within Network, or outside Network 3. Information collected from Investigators outside progress reports

9. Data Model Visual representation of the structure of the progress report data Used to formally describe data relationships Example relationships: Which people contributed to a project? Which projects does a progress report identify? Which publications has a person written?

10. Data Model Diagram

11. SQL Database Stores data entered through the Data Entry User Interface Entered data can be queried to support charting and data export in the Analysis User Interface Database Data Entry User Interface

12. iTRAQR – Phase 1

13. Evaluation Metrics Investigators and Trainees Network and Center Collaborations Trans-Disciplinary Authorship Collaborations Field Convergence (Physical Sciences/Oncology) Time series analysis of Physical Sciences and Oncology term concurrent in the literature Types of publications that investigators are generating Types of journals that investigators are publishing (before/after)

14. PS-OC Network: Who? Network Trainees and Investigators Trainees = Undergraduates, Graduates, Post-Doc, Research Associate, Medical Student Trainees Investigators Both Physical Scientist and Cancer Biologists at all levels Physical Sciences Cancer Biology Both

15. PS-OC Network: How do we interact? Network Level - June 2011 Annual Report Project/Core Collaborations Reported by both PSOC (15) Project/Core Collaborations Reported by one PSOC (68)

16. PS-OC Network: How do we interact? Center Level UC Berkeley PS-OC Princeton PS-OC Cornell PS-OC Examples of 3 PS-OC Center Interactions Each PS-OC is unique in the structure and degrees of interactions between Research Projects

17. Trans-Disciplinary Collaborations Analysis of Authorship Collaborations Node: Network PI (Physical Scientist, Oncologist) Line: Network Co-authorship PI pair (PS-PS, OC-OC, PS-OC) PS-OC Investigator Collaborations Pre-Award (2000-2008) vs. Post-award (2009 - present) 19 per year

18. Node: Network PI (Physical Scientist, Oncologist) Line: Network Co-authorship PI pair (PS-PS, OC-OC, PS-OC) Analysis of Collaborations 8% increase in trans-disciplinary authorship collaborations since the start of the PS-OC program Physical Sciences PIs Cancer PIs Physical Sciences & Cancer PIs Trans-Disciplinary Collaborations Analysis of Authorship Collaborations PS-OC Investigator Collaborations Pre-Award (2000-2008) vs. Post-award (2009 - present) 19 per year 62 per year

19. Field Convergence Set of Cleaned MeSH Terms Journal Category Physical Sciences Journals Cancer Journals Publications MeSH Terms Non-Descriptive Terms Cancer Terms Physical Sciences Terms 695 843 109 Physical Sciences MeSH Terms Cancer MeSH Terms

20. Field Convergence Analysis of PS-OC Investigators Publications Use sets of MeSH terms to categorize PS-OC investigator publications Start of PS-OC program (September 2009) ?

21. Physical Sciences PIsCancer Biology PIs Physical SciencesCancer Physical Sciences & CancerNon-Descriptive Field Convergence Analysis of PS-OC Investigators Publications

22. Physical Sciences in Oncology (physics.cancer.gov) More Information Larry A. Nagahara, Ph.D. Email: larry.nagahara@nih.govlarry.nagahara@nih.gov Nicole M. Moore, Sc.D. Email: nicole.moore@nih.govnicole.moore@nih.gov Nastaran Z. Kuhn, Ph.D. Email: Nastaran.kuhn@nih.govNastaran.kuhn@nih.gov Sean E. Hanlon, Ph.D Email: hanlonse@mail.nih.govhanlonse@mail.nih.gov Mariam Eljanne, Ph.D. Email: mariam.eljanne@nih.govmariam.eljanne@nih.gov