1. Wake Forest School of Medicine Translational Imaging Program Wake Forest Translational Science Institute (TSI) Akiva Mintz, MD, PhD, MHA

2. Golden B. Transforming healthcare Organizations. Healthcare Quarterly; 10:2006 Change Success vs. Failure Translational Imaging Program

3. Imaging as a Value-Adding Proposition TQM13 Vision Resources Action Plan Discussion Newcastle upon Tyne

4. Clinical Scanners microPET Research PET Scanner Staff 7T Preclinical MRI Cyclotron Clinical Radiologists Radio- chemistry 3T Large Research MRI Regulatory Support Resources & Structure

5. Clinical Scanners microPET Research PET Scanner Staff 7T Preclinical MRI Cyclotron Clinical Radiologists Radio- chemistry 3T Large Research MRI Regulatory Support Resources & Structure

6. Clinical Scanners microPET Research PET Scanner Staff 7T Preclinical MRI Cyclotron Clinical Radiologists Radio- chemistry 3T Large Research MRI Regulatory Support Resources & Structure

8. Clinical Scanners microPET Research PET Scanner Staff 7T Preclinical MRI Cyclotron Clinical Radiologists Radio- chemistry 3T Large Research MRI Regulatory Support Resources & Structure

9. Translational Imaging Program Synergizing Assets

10. Preclinical and Clinical Synergy TQM13 Translational Imaging Program (TIP) Benchtop Bedside Research & Clinical Practice Preclinical Imaging Radio-Tracer Development

11. Translational Imaging Program Roadmap to Excellence Workflow Efficiency Collaboration Customer Satisfaction Education Innovation

12. Phys. Pharm Cardio. Diabetes Neuro BioEng. Aging Center Dementia Cancer Center WFIRM Synergizing Assets TIP Translational Imaging Program

13. Synergizing Assets Wake Innovation Industry Translational Imaging Program

14. 7T Small Animal MRI Scanner microPET/CT Scanner Human Research PET/CT Scanner Radiotracer Synthesis Laboratory Cyclotron 3T MRI Translational Imaging Shared Resource Consultation – Multi modality expertise Access/Rates – negotiate center subsidized rates, PPG imaging cores Tracers – develop tracers in areas of institutional priority Proactive Catalyst – Work with potential investigators who do not currently use imaging Pilot mechanism Cross-pollinate novel imaging applications between seemingly unrelated projects – example: cancer metabolism and AD Value Added Translational Imaging Program

15. Proposed Structure Translational Imaging Program

16. Proposed Structure Translational Imaging Program TSI Team Chris OByrne Laurie Molloy Janeria McCullough Mike Kennedy Pattie Smith Rachel Woodside Lindsay Trost Meredith Hankins

17. Imaging as a Value-Adding Proposition TQM13 Vision Resources Action Plan Discussion Newcastle upon Tyne

18. TQM13 Technology/Equipment o Siemens 3.0T Large MRI o GE 16-slice PET/CT o Toshiba 32-slice CT o Imaging Informatics Infrastructure

19. TQM13 Technology/Equipment o Siemens 3.0T Large MRI o Bruker 7T small animal MRI o GE 16-slice PET/CT o Trifoil MicroPET/CT o Toshiba 32-slice CT o Imaging Informatics Infrastructure

20. TQM13 Tracer Manufacturing PET cGMP Production

21. Wake Forest Cyclotron (GE PET Trace) Wake Forest Radiotracer Synthesis Laboratory Trasis All-In-One GE TRACERlab FxC 4 Active Hot Cells TQM13 Tracer Manufacturing PET Tracer cGMP Production GE TRACERLAB FX MEI GE TRACERLAB FX M

22. TQM13 Agilent Gas Chromatography (GC) 3 HPLCs for QC and Development Terra Universal USP797- Compliant Class 5 Isolation Chamber TQM13 Tracer Manufacturing PET Tracer cGMP Production

23. Imaging as a Value-Adding Proposition TQM13 Vision Resources Action Plan Discussion Newcastle upon Tyne

24. Golden B. Transforming healthcare Organizations. Healthcare Quarterly; 10:2006 Change Success vs. Failure Translational Imaging Program

25. Administration Changes Translational Imaging Program Announcements New Website https://ctsi.wakehealth.edu/translational-imaging-program Electronic intake Updated contacts Outreach Pilot Program ID Areas of Need: Novel radiochemistry, Image Processing

26. TQM13 Key Areas Adaptive Clinical Trials/Early Response Metabolism Imaging Immune Modulation Clinical Protocol Development Imaging Pilots Immune Activation FA Metabolism Anti-mitochondrial Metabolism GBM Imaging Targeted Strategic Plans Example: Cancer

27. Novel Radiochemistry Small Animals Large Animals Clinical Trials Oncology Regenerative Med. AD/Neuroscience Metabolism Cardiology Partial Listing of Available Tracers 18 F-FLT 18 F-FMISO 11 C-Choline 11 C-Methionine 11 C-Acetate 11 C-PBR28 18 F-FMT 18 F-FES 18 F-FDHT 18 F-FDopa 89 Zr-mAb TQM13 Targeted Strategic Plans Example: Cancer

28. TQM13 TIP Alzheimer’s Disease Addiction Metabolism Diet Non Human Primate Models Cancer Bridging Foci to Create New Science Translational Imaging Program

29. Current Vision or Dream?