1. Chapter 12: Alcohols from Carbonyl Compounds CH 12-1 Alcohol RedOx Oxidation (loss of H) of alcohols to form carbonyls Reduction (gain of H) of carbonyls to form alcohols Multi-step synthesis strategy Grignard reaction: forming alcohols and new C-C bonds

2. Organic Oxidation/Reduction Reactions: Alcohols/Carbonyls Oxidation of alcohols involves loss of H, hybridization change, and formation of C=O bonds. Reduction of carbonyls involves addition of H, hybridization change, and loss of C=O bonds. alcohol carboxylic acid aldehyde (or ketone) The “strength” of the oxidizing or reducing reagent will dictate the functional groups made or transformed.

3. Reagents for Alcohol Oxidation (reactions only, no mechanisms) Oxidation of 1 o alcohols to aldehydes with “PCC”: Oxidation of 2 o alcohols to ketones with Chromic Acid: What about the oxidation of 3 o alcohols?

4. Reduction of the Carbonyl Group to Alcohols with NaBH 4 (reactions only, no mechanisms)