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Size and apolipoprotein composition are the main factors determining atherogenicity of triglyceride-rich particles.

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Presentation on theme: "Size and apolipoprotein composition are the main factors determining atherogenicity of triglyceride-rich particles."— Presentation transcript:

1 Size and apolipoprotein composition are the main factors determining atherogenicity of triglyceride-rich particles

2

3 Apo C-III modulates VLDL

4 Apo C-III in apo B particles is atherogenic

5 Relationship between apo C-III in apo B containing lipoproteins and atherogenicity

6 PROCAM Study MI-Incidence according to LDL-cholesterol and triglycerides

7 PROCAM Study CHD risk according to LDL-C and TG increased TG confers raised CHD risk at all levels of LDL-C

8 HDL: an anti-atherogenic lipoprotein

9 HDL metabolism: 5 key genes

10 HDL: apo AI-rich particles

11 Apo A-I protects against atherosclerosis

12 Apo A-II protects against atherosclerosis The human apo A-II transgenic mouse model


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