1. Tuesday1/19/2016 Agenda: Pedigrees  Notes: Pedigrees  Activity: Pedigree Worksheet  Activity: Genetics Review Guide  GENETICS EXAM WEDNESDAY/THURSDAY 1/20-1/21/2016 Homework/Class Work: Pedigree Worksheet and Review Guide due Wednesday/Thursday 1/20-1/21/2016 for 30 Points

2. Understanding a Pedigree Chart A family history of a genetic condition

3. Genotypes and Phenotypes Mom and Dad are Rr-that is their genotype, they can also be described as heterozygous- they have 1 of each gene What is their PHENOTYPE? The youngest son has a genotype of rr-he is Homozygous recessive-2 copies of the recessive gene His phenotype? I can’t Roll my Tongue!

4. Some common dominant and recessive traits Widow’s peak is dominant. You can be homozygous dominant (WW) or heterozygous (Ww) and you will have widow’s peak What is your genotype and phenotype if you’re homozygous recessive?

5. Making a Pedigree Chart Pedigree charts are made to chart family history and see how traits are passed A genetic counsellor will use pedigree charts to help determine the distribution of a disease in an affected family

6. Symbols Shade individuals that have the trait you’re studying Boys = squares (Lucy always calls Charlie Brown a ‘block head’) Girls = circles

7. Married-connected at side Siblings-connected at TOP not at the side (hopefully not siblings AND married) Oldest child-to the left Question-if shaded individuals in this pedigree have blue eyes, what is the GENOTYPE of the parents? Making a Pedigree Chart

8. Other Divorced, separated Deceased Identical twins Fraternal twins

9. Generations are identified by Roman numerals Organizing the pedigree chart I II III IV

10. Organizing the pedigree chart Individuals in each generation are identified by Arabic numerals numbered from the left Therefore the affected individuals are II3, IV2 and IV3 I II III IV 1 2 34567

11. What’s going on? Shaded = blue eyes 1 and 2 split after having 4, 2 then had kids with 3 and split with her too after 5-9 were born Genotypes of 1, 4,7? Genotypes of 2 & 3? Genotypes of 5,6, 8, 9, 10, 11, 12?