1. Lecture 22 Web: pollev.com/ucibio Text: To: 37607 Type in: 169964

2. Hormonal regulation

3. The TCA

4. The brain problem… Most energy stored as fatty acids Brain only uses Glc Fatty acids  Glc? How does brain function during starvation?

5. Production of ketone bodies Starvation  Glycogen = 1 day Amino acids  Glc. BUT… Without TCA, liver makes “Ketone bodies” from fats

6. Ketone bodies

7. Diabetes & ketone bodies Extreme starvation  Muscle breakdown Brain has plenty of Glc!

8. If only…

9. Making fatty acids = adding 2 Cs to chain!

10. AcCoA  Malonyl CoA

11. ACP in FAS

12. FAS

14. Fatty acid synthesis

15. Substrate shuttling in FAS

17. Further steps…

19. Regulation of FAS & breakdown

20. Allosteric regulation of ACC