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Chinese and Japanese are very similar in phenotype.

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Presentation on theme: "Chinese and Japanese are very similar in phenotype."— Presentation transcript:

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2 Chinese and Japanese are very similar in phenotype.

3 Expression variation among Chinese and Japanese individuals Differently expressed Illumina's commercial whole genome expression array, Sentrix Human-6 Expression BeadChip version 2 These arrays utilize a bead pool with ~48,000 unique bead types Each with several hundred thousand gene-specific 50mer probes attached.

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6 Genome locations of 768 DE genes

7 Functional enrichment of 768 DE genes

8 Identify local (Cis) and distant (Trans) genetic regulators that associate with gene expression difference PopulationCis: # genes(snps)Trans: # genes(snps) CHB39 (306)271 (4544) JPT68 (648)92 (1216)

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12 CTSS vs cis-SNPs

13 Dr. Shuhua Xu Yang ling, Lu dongsheng, Shi meng, Lou haiyi Jin wenfei, Pankaj All in population genomics group


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