2. Plague Black Death Black Plague Bubonic Plague Pestilence
The Great Plague

3. Three Types of Plague
Bubonic Plague
Pneumonic Plague
Septicemia Plague (blood infection)

4. Bubonic Plague Caused by bacteria:
Yersinia pestis
Carried by fleas – that live on rodents - often rats (can be dogs, cats, squirrels, etc.)
During the 1300’s; One quarter of the population of Europe died.
Mortality = 30-75%

5. Pneumonic Plague Caused by bacteria: Less common than Bubonic plague
Yersinia pestis
Less common than Bubonic plague
Most victims die
Mortality 90-95%
Infects the lungs
“Sheepshearer’s Disease”

6. Septicemia Plague Rarest of all plagues Mortality near 100%
Even today no treatment
“DIC” = disseminated intravascular coagulation

7. Septicemia Victim

8. Bubonic Plague Victim
Bubo = tender swollen area, often in the groin area or in the armpit.
Also appears in area where flea has bitten victim
“Bubo”

9. Bubonic

10. The Black Death Victim recovering from Bubonic Plague
At one time his entire body was black

11. Black Death Victim Same victim Toes have gangrene
Probably will have to be amputated

12. Mammalian Victim Pneumonic plague Rock squirrel in Colorado
Coughing up sputum from pneumonic plague

13. Death Toll
Most historians agree that the Black Death killed between 30-45% of the European population between 1348 & 1350
25 million people died between 1347 & 1352

18. CCR5 gene – Delta 32 Mutation
Located on Chromosome 3
Some people inherit one or two of these
Dd or dd
Heterozygous or Homozygous Recessive
Provided resistance against the plague
Now provides resistance against HIV

19. CCR5 codes for White Blood Cell

20. CCR5 Mutation % Europe

21. CCR5 Mutation = World

22. News of the Week …
Bubonic Plague In 2015? Madagascar's Current Plague More Virulent Than Strain From Dark Ages
Jan 28, :53 PM By Dana Dov
No, you did not misread the headline to this story. Not only does the bubonic plague still exist, but it’s infected hundreds of individuals on the island of Madagascar, off the coast of Africa. In fact, this is nearly an annual occurrence for the island nation. Unlike the plague of the past, however, this form is not only harder to contain but can kill nearly 24 hours after initial exposure.

23. Secrets of the Dead: Black Plague

24. Black Plague Kristie Kazimir and Alex Bester