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Circulating FGF21 proteolytic processing mediated by fibroblast activation protein by Eugene Y. Zhen, Zhaoyan Jin, Bradley L. Ackermann, Melissa K. Thomas,

Published byDominic Thornton Modified over 8 years ago

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Presentation on theme: "Circulating FGF21 proteolytic processing mediated by fibroblast activation protein by Eugene Y. Zhen, Zhaoyan Jin, Bradley L. Ackermann, Melissa K. Thomas,"— Presentation transcript:

1 Circulating FGF21 proteolytic processing mediated by fibroblast activation protein by Eugene Y. Zhen, Zhaoyan Jin, Bradley L. Ackermann, Melissa K. Thomas, and Jesus A. Gutierrez Biochem. J. Volume 473(5):605-614 March 1, 2016 ©2016 by Portland Press Ltd

2 MALDI analysis of hFGF21 degradation in plasma Eugene Y. Zhen et al. Biochem. J. 2016;473:605-614 ©2016 by Portland Press Ltd

3 The levels of FGF21 processed products in healthy volunteer donors Eugene Y. Zhen et al. Biochem. J. 2016;473:605-614 ©2016 by Portland Press Ltd

4 FAP digestion of human and mouse FGF21 Eugene Y. Zhen et al. Biochem. J. 2016;473:605-614 ©2016 by Portland Press Ltd

5 FGF21 processing in plasma with FAP inhibitor or FAP immunodepleted Eugene Y. Zhen et al. Biochem. J. 2016;473:605-614 ©2016 by Portland Press Ltd

6 Human FGF21 cleavage in mouse plasma from wild-type and FAP knockout mice Eugene Y. Zhen et al. Biochem. J. 2016;473:605-614 ©2016 by Portland Press Ltd

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