1. Ponpon’s Laboratory Room: D916 (Lab) ; D908 (Office) Department of Life Science, Tzu-Chi University 970 Hualien Taiwan EBV research group

2. Epstein-Barr Virus (EBV) 1.Human gamaherpesvirus 2. 184 kb DNA, double strand, linear 3. EBV associated diseases Burkitt’s Lymphoma Hodgkin’s Disease Nasopharyngeal Carcinoma (NPC) Lymphoproliferative Disease EBV

3. Epithilium of oropharynx Persistent infection of B cells by EBV Downregulation of EBV gene Memory B cell infection Cytotoxic T cell GC B cell Naive B cell Cytotoxic T cell EBV infection No SHM

4. Orip Wp CpQp EBNALP EBNA2 EBNA3s EBNA1 AB C LMP2A/B LMP1 Latency I Latency II Latency III Wp using BL Latent infection mediated by EBV

5. EBNA2 EBNALP EBNA3A EBNA3B EBNA3C EBNA1 EBV episomes EBV efficiently converts human B lymphocyte into proliferating lymphoblasts Resting B cell LCL EBNA2 Binds to RBP-Jk Transactivates - EBNA Cp, LMP1 - c-Myc, CD21, CD23 LMP1 Recruits TRAFs Activates NF-kB, JNK Mimics CD40 signaling EBV LMP2A LMP1 LMP2B EBNA3s Regulators of EBNA2 function? EBNALP Co-activates with EBNA2

6. Young ladies lead our group 小尤 Miley Mo 伶芝 雅琳 冠吟

7. Members in Ponpon’s Lab. Research Assistant: Guan-Yin Liu Ling-Chih Chien Undergraduate: Yi-Liy Ming Yi-Ting Yu Ya-Ling Chen Gadd family BAG family p53 pKA and p21 EBNA1 PI: Pon 2 Hsp90 LMP1 vs Cp Gene therapy ganoderma4725@gmail.com pengcw@mail.tcu.edu.tw cheery620@yahoo.com.tw 93711128@stmail.tcu.edu.tw Fu-Yue Hsu: 93711152@stmail.tcu.edu.tw Graduate student: jgiu334@yahoo.com.tw debby969@hotmail.com Ongoing project