1. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 ReDVA Meeting in Paris Guerbet, Villepinte, FR April 3-4, 2014 E. Lancelot

2. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction Day 1 – workpackages 2 & 3 orientation program Day 1 – brainstorming session Day 1 – plenary session Day 2 – workpackages 4 & 5 orientation program Day 2 – workshops Day 2 - conclusion Agenda of the meeting 2

3. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction Day 1 – workpackages 2 & 3 orientation program Day 1 – brainstorming session Day 1 – plenary session Day 2 – workpackages 4 & 5 orientation program Day 2 – workshops Day 2 - conclusion Agenda of the meeting 3

4. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction –Welcome and logistic matters (E. Lancelot – 5 min) –Update on the project developments Organizational matters (G. Houston – 15 min) Administrative matters (J. Wyatt – 15 min) Agenda of the meeting 4

5. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction Day 1 – workpackages 2 & 3 orientation program Day 1 – brainstorming session Day 1 – plenary session Day 2 – workpackages 4 & 5 orientation program Day 2 – workshops Day 2 - conclusion Agenda of the meeting 5

6. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – workpackages 2 & 3 orientation program –Key questions (G. Houston – 5 min) –Methodology (G. Houston – 10 min) –ERBP questionnaires (N. Inston – 15 min) –Deliverables and Gant chart (E. Lancelot – 15 min) Agenda of the meeting 6

7. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – workpackages 2 & 3 orientation program –Key questions (G. Houston – 5 min) –Methodology (G. Houston – 10 min) –ERBP questionnaires (N. Inston – 15 min) –Deliverables and Gant chart (E. Lancelot – 15 min) Agenda of the meeting 7 How are central vein problems assessed in the pre-operative setting? What is the place of CT and MRI? How are these problems managed, once detected? What types of interventions are available in case of failing VA site? How is the surveillance of VA sites performed?

8. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – workpackages 2 & 3 orientation program –Key questions (G. Houston – 5 min) –Methodology (G. Houston – 10 min) –ERBP questionnaires (N. Inston – 15 min) –Deliverables and Gant chart (E. Lancelot – 15 min) Agenda of the meeting 8 Literature review Retrospective analysis of ReVDA Partners data Local and European databases Two levels of questions: Deep vein catheters: who is doing what? MRI and CT: what are they used for and how?

9. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – workpackages 2 & 3 orientation program –Key questions (G. Houston – 5 min) –Methodology (G. Houston – 10 min) –ERBP questionnaires (N. Inston – 15 min) –Deliverables and Gant chart (E. Lancelot – 15 min) Agenda of the meeting 9 The PICO method Use of the EROS system List of topics relevant to VA How to elaborate the questionnaires and who should receive them?

10. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – workpackages 2 & 3 orientation program –Key questions (G. Houston – 5 min) –Methodology (G. Houston/N.Inston – 10 min) –ERBP questionnaires (N. Inston – 15 min) –Deliverables and Gant chart (E. Lancelot – 15 min) Agenda of the meeting 10 Who should do what and when?

11. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction Day 1 – workpackages 2 & 3 orientation program Day 1 – brainstorming session Day 1 – plenary session Day 2 – workpackages 4 & 5 orientation program Day 2 – workshops Day 2 - conclusion Agenda of the meeting 11

12. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – brainstorming session –Group 1 – « what are the strengths and weaknesses of each imaging modality in relation to VA solutions and implantation sites? » (J. Ayub – 45 min) –Group 2 – « evidence-based clinical practice in relation to VA assessment: what are the challenges? » (E. Lancelot – 45 min) –Group 1 – feedback (J. Ayub – 15 min) –Group 2 – feedback (E. Lancelot – 15 min) Agenda of the meeting 12

13. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – brainstorming session –Group 1 – « what are the strengths and weaknesses of each imaging modality in relation to VA solutions and implantation sites? » (J. Ayub – 45 min) –Group 2 – « evidence-based clinical practice in relation to VA assessment: what are the challenges? » (E. Lancelot – 45 min) –Group 1 – restitution (J. Ayub – 15 min) –Group 2 – restitution (E. Lancelot – 15 min) Agenda of the meeting 13 G. Houston + JS. Raynaud + S. Gandy + S. Kokkalis + Z. Kwhawaja + M. Walsh+ R. Ross + J. Alshakarchi + L. Brown N. Inston + R. Jones + D. Cassidy + S. Matthew + P. Hoskins + P. Stonebridge + S. Broderick + D. Newport + J. Wyatt + S. Bell

14. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction Day 1 – workpackages 2 & 3 orientation program Day 1 – brainstorming session Day 1 – plenary session Day 2 – workpackages 4 & 5 orientation program Day 2 – workshops Day 2 - conclusion Agenda of the meeting 14

15. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – plenary session – VA Clinical Aspects –Clinical aspects of VA site disease (N. Inston – 20 min) –Imaging modalities for VA site assessment (R. Jones – 20 min) –Techniques for intervention on failing VA (P Stonebridge– 20 min) Agenda of the meeting 15

16. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction Day 1 – workpackages 2 & 3 orientation program Day 1 – brainstorming session Day 1 – plenary session Day 2 – workpackages 4 & 5 orientation program Day 2 – workshops Day 2 - conclusion Agenda of the meeting 16

17. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 2 – workpackages 4 & 5 orientation program Lab based work in AV access: -Pressure flow rigs and CFD(M Walsh 10 mins) -Blood mimics and Ultrasound (P Hoskins 10 mins) -Flow visualisation (E Kokkalis 10 mins) Key Questions definition discussion (20 mins) (will be defined by above on Thursday am!) Agenda of the meeting 17

18. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction Day 1 – workpackages 2 & 3 orientation program Day 1 – brainstorming session Day 1 – plenary session Day 2 – workpackages 4 & 5 orientation program Day 2 – workshops Day 2 - conclusion Agenda of the meeting 18

19. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 2 – workshops –High-resolution imaging techniques for VA site assessment – technical considerations (JS. Raynaud & S. Gandy – 30 min) –Managing VA in haemodialized patients – the patient and clinicians view point (S. Matthew & S Bell – 30 min) –Laboratory-based techniques for VA site assessment – translational research in support of clinical research (M. Walsh & P Hoskins – 30 min) Agenda of the meeting 19

20. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 2 – workshops –Summary of the discussions (JS. Raynaud & S. Gandy – 10 min) –Summary of the discussions (S. Matthew – 10 min) –Summary of the discussions (M. Walsh – 10 min) Agenda of the meeting 20

21. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 1 – welcome and introduction Day 1 – workpackages 2 & 3 orientation program Day 1 – brainstorming session Day 1 – plenary session Day 2 – workpackages 4 & 5 orientation program Day 2 – workshops Day 2 - conclusion Agenda of the meeting 21

22. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Day 2 - conclusion –Next steps – scientific aspects (G. Houston – 10 min) –Next steps – administrative aspects (J. Wyatt – 10 min) Agenda of the meeting 22

23. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 Agenda Scientific Advisory Board Meeting Agenda G Houston (30 mins) Title of Presentation - Date, Confidentiality level Page 23

24. This project has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 324487 24 Thank you for your participation ! See you at the next ReDVA meeting !