1. Statistics and Processing Working Group AHM Fall 2009

2. Tool Development Voxel-based variance components/ICC analysis (UCSF: MatLab, UCSD: R) Textual knowledge discovery: Document classification and named entity recognition. (Ozyurt) Gaussian based spatial activation modeling method (Kim, Smyth, Stern). Markov Random Field approaches to spatial noise reduction (Ou, Wells, Golland). Disease relevant SNPs and fMRI associations (Calhoun)

3. Some Interim Results

4. Impact of Age on functional activation in schizophrenia and healthy volunteers: Auditory Oddball Task (Mathalon et al.).

5. Bayesian Hierarchical Analysis: SIRP Probe Copes L. H.R. H.L. H.R. H. Posterior distributions of DLPFC mean copes as a function of memory load and hemisphere

6. Markov Random Field Approach to Spatial Noise

7. 1.00 0.00 1 run 2 runs 3 runs 4 runs 5 runs 6 runs 7 runs 8 runs Between Site ICC

8. Papers: Major WG Goal for Year 5

9. Papers in Progress Ou, W., Wells, W.M., Golland, P., (2009) Improved fMRI Detection via Combining Spatial Regularization and Anatomical Priors. Manuscript under review. Kim S., Smyth P., Stern H. (2009) A non-parametric Bayesian approach to modeling spatial activations in multi-site fMRI data. Manuscript under review. Kim, M. A., Tura, E., Potkin, S.G., Fallon, J.H., Manoach, D.S., Calhoun, V.D., FBIRN, Turner, J.A. (2009). Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensation. Manuscript under review.

10. Papers in Progress Functional pathology progresses with age in schizophrenia: A multi-site fMRI study. (D. Mathalon, K. Jorgensen, B. Roach) Bayesian hierarchical analysis of multi-site, mutli-group FMRI data. (Kinh, Wells, Stern). Human QA paper (s) (Mathalon, Jorgensen, Notestines) Partial least squares (J. Turner) ICA papers (Calhoun and colleagues)

11. Papers in Progress Two ASL reliability papers. First paper ( Rasmussen, Liu)l Second paper ( Wierenga, Brown) Impact of run averaging and functional contrast on the reliability of functional magnetic resonance imaging data: [ECTS](Brown, Mathalon,) Effects of breath hold calibration on the between –site reliability of functional MRI data (Brown, Glover) Variance components analysis of Phase II data (Mathalon, Jorgensen) Best Practices: Lessons Learned

12. Statistics Activities at AHM Multivariate Approaches for Imaging Data (Today 4:15 PM) –Wes Thompson. Smoothing Spline ANOVA: East-Coast Traveling Subjects Study –Vince Calhoun. SNPs, Functional Connectivity, Patient/Control Differences seen through the ICA Lens. Statistical Contributions to Cookbook Paper (Tuesday 8:30 AM to 10:00 AM) Paper discussion clusters (Tuesday 10:30 AM to noon) –Sandy Wells and Mat Toews: Feature Based Image Analysis –Others?