1. Carmen Nájera Department of Organic Chemistry University of Alicante Alicante (Spain) Cross-Coupling Reactions in Aqueous Media 1 2 nd International Conference on Past and Present Research Systems of Green Chemistry September 14-16, 2015 Orlando, USA 2 nd International Conference on Past and Present Research Systems of Green Chemistry September 14-16, 2015 Orlando, USA

2. 2

3. 3

4. 4

5. 5

6. Challenge: very active catalyst ArCl activation ArOH activation C sp 3 activation C-H activation Catalysis in water Mild reaction conditions 6

7. High thermal, air and moisture stability Easy accessibility Unexpensive starting materials (ketones) Amenable to structural and electronic variations Features 7

8. 8 Synthesis

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10. 10

11. 11

12. 12 Allylic alcohols

13. 13

14. 14 Arylations in H 2 O

15. 15

16. 16

17. 17 Aryl Chlorides + Arylboronic Acids

18. 18 Aryl Chlorides + Alkylboronic Acids

19. 19

20. 20 A. Corma et al., Chem. Commun. 2003, 606

21. 21 Aryl Chlorides + Potassium Aryltrifluoroborates

22. 22

23. 23

24. 24 Allyl and Benzyl Chlorides + Arylboronic Acids

25. 25 Allyl Chlorides + Potassium Aryltrifluoroborates

26. 26 Benzyl Chlorides + Potassium Aryltrifluoroborates

27. 27 Allyl and Benzyl Chlorides + Potassium Alkenyltrifluoroborates

28. 28

29. 29 1-Naphthol derivatives studies

30. 30 Aryl Imidazole-1-sulfonates: reaction conditions in water

31. 31 Aryl Imidazole-1-sulfonates + Potassium trifluoroborates

33. 33

34. 34 Aryl Imidazole-1-sulfonates: ligands study

35. 35 Aryl Imidazole-1-sulfonates: scope

36. 36

37. 37 Aryl Chlorides: surfactants study

38. 38 Aryl Chlorides: scope

40. 40 Synthesis of (E)--1,4-Enynes: ligand studies

41. 41 Synthesis of (E)--1,4-Enynes: Pd source

42. 42 Synthesis of (E)--1,4-Enynes: scope

44. 44 Synthesis of 5-Carbapterocarpens

46. 46 Synthesis of Pterocarpans and 5-Carbapterocarpans

48. 48 Carbonylations in water

49. 49 Synthesis of Amides and Nitriles

50. 50

51. 51

52. 52 Spanish Ministry of Science and Innovation: BQ2001-0724, CTQ2004-00808, Consolider INGENIO 2010 CSD2007-00006, CTQ2007-62771/BQU, CTQ2010-20387 Spanish Ministerio de Economia y Competitividad: CTQ2013-43446-P, CTQ2014-51912-REDC FEDER Generalitat Valenciana: PROMETEO/2009/039 and PROMETEOII/2014/017 University of Alicante CAPES (Brazil)

53. 153

54. 54 Dimeric complexes Supported complexes