1. Ch 43 The Body’s Defense

2. Three lines of Defense: 1. External defenses 2. Internal (phagocytes, inflammation) 3. Specific defense: (lymphocytes) 1 & 2 are non-specific, innate 3 is specific, acquired

3. Phagocytosis (WBC’s) non-specific By Monocytes which turn into Macrophages (long-lived) and also neutrophils Eosinophils natural killer cells Dendritic cells

4. Inflammatory Response: non-specific Basophils and Mast cells release histamines

5. Other non-specific responses to infection: Fever Antimicrobial proteins Interferons: inhibit viral reproduction

6. Pathogen, antigen, epitope (antibody generator) Self vs. Non-self? Blood groups (A, B, AB, O antigens) Lymphocytes: (mature in thymus or bone marrow) Helper T cells: T H Cytotoxic T cells: T c (enzymes, cell mediated immunity) Suppressor T cells: T s B cells (antibodies, humoral immunity) Memory B’s Plasma cells What is specific immunity?

7. http://video.google.com/videoplay?docid=- 7586835408270491809&q=immune+response&total=1621&start=0&num=10&so=0&type=search&plindex=0

9. Overview video ://video.google.com/videoplay?docid=- 8860381196434790126&q=antibody+immune+response&total=44&start=0&num=10&so=0&type=search&plindex=1 ://video.google.com/videoplay?docid=- 8860381196434790126&q=antibody+immune+response&total=44&start=0&num=10&so=0&type=search&plindex=1

11. What is the second response like? Immunological Memory:

12. Cell surface markers in T cell function MHC (major histocompatibility complex) “Self” Cell surface proteins, recognized by different T cells Present the antigen to the T cells, initiates helper T cell responses

13. Perforin, cell to cell attack

14. Cytokine (Interleukins) and Helper T cells What is interleukin?

15. Cytotoxic T cells, perforin What is an APC? Why does water rush in when a pore is created by perforin?

16. Effector B-cells Memory B-cells Make antibodies Antigen driven cloning of lymphocytes: Clonal selection

17. Mechanisms of Humoral immunity: ANTIBODIES

18. Antibody structure and function Igs HIV / AIDS Active vs passive immunity Vaccines (pgs. 852-861)

21. These are slides we did not use this year (2008)

24. lymph nodes, bone marrow, thymus, spleen

25. Most cells of the body: Macrophages, B cells, nucleated activated T cells, thymus CD4 CD8 Kills the infected cell Alerts B & T cells

26. Perforin, cell to cell attack