1. بسم الله الرحمن الرحيم

2. Accessory gland of Digestive system salivary gland liver pancreas gall bladder

3. liver largest organ and gland = 1.5 kg location: abdominal cavity beneath diaphragm

4. function -production of proteins (albumin, fibrinogen) -detoxification -production of bile (lipid digestion ) -accumulation & change of metabolite -double circulatory system: portal vein (70-80%) hepatic artery

5. structure: -Capsule (glisson's capsule) -trabeculae -lobe, lobule -hilum

6. 1- hepatocyte: 2- sinusoids : Stroma: reticular connective tissue

7. Hepatocyte

8. Hepatocyte = polyhedral = 6 or more surface contact with: sinusoid wall contact with: with other hepatocyte

9. contact with other hepatocyte 1-tubular space canaliculi (first portin of bile duct system ) 2-fuse=2 plasma membrane tight junction gap junction

10. contact with sinusoid wall Disse space:Ito cell (fat storing cell) =stellate cell

11. Sinusoids: 1-Endothelial cell 2-kupffer cell(phagocytotic cell, product protein=5%)

12. Sinusoids:

13. The liver lobule 1-classic lobule 2-portal lobule 3-hepatic acinus (rappaport)

14. classic lobule -polygonal -centeral vein (center of lobule) -Hepatocyte( hepatic cord = radial) -Sinosoid= radial -Portal space= between different lobule

16. Portal space =Portal triad / space 1-Bile duct 2-hepatic arteriol 3-portal vein Nerve lymphatic vessel

19. Portal lobule center portal triad

20. hepatic acinus ( rappaport lobule ) diamond – shape Center of lobule = terminal branch of portal vein, -

22. double circulatory system 1-portal vein (70-80%) 2-hepatic artery hilum

23. portal vein

24. Bile ductal system --bile canaliculi -bile ductules (Hering canal) = simple cuboidal cell -bile duct

25. Bile canaliculi

26. در لحظات شادی ،خداوند را ستايش کن در لحظات سختی خداوند را جستجو کن در لحظات آرامش خداوند رامناجات کن در لحظات درد آور به خداوند اعتماد کن ودرتمام لحظات خداوند را شکر کن

27. Gall bladder

31. animation