1. Cardiovascular System The Heart Dr. M. Diamond

2. Cardiovascular System A closed system of the heart and blood vessels –The heart pumps blood –Blood vessels allow blood to circulate to all parts of the body Function –to deliver oxygen and –nutrients and –remove carbon dioxide and other waste products

3. Heart Location –Thorax between the lungs in the inferior mediastinum Orientation –Pointed apex directed toward left hip –Base points toward right shoulder About the size of your fist

4. The Heart: Coverings Pericardium—a double-walled sac –Fibrous pericardium is loose and superficial –Serous membrane is deep to the fibrous pericardium and composed of two layers Visceral pericardium –Next to heart; also known as the epicardium Parietal pericardium –Outside layer that lines the inner surface of the fibrous pericardium –Serous fluid fills the space between the layers of pericardium

5. Heart Wall Three layers –Epicardium Outside layer This layer is the visceral pericardium Connective tissue layer –Myocardium Middle layer Mostly cardiac muscle –Endocardium Inner layer Endothelium

6. Heart Chambers Right and left side act as separate pumps Four chambers –Atria Receiving chambers –Right atrium –Left atrium –Ventricles Discharging chambers –Right ventricle –Left ventricle

7. Heart Septa Interventricular septum –Separates the two ventricles Interatrial septum –Separates the two atria

8. Heart Valves Allow blood to flow in only one direction Prevent backflow Four valves –Atrioventricular (AV) valves— between atria and ventricles Bicuspid (mitral) valve (left side of heart) Tricuspid valve (right side of heart) –Semilunar valves—between ventricle and artery Pulmonary semilunar valve Aortic semilunar valve

9. Lub, dup AV valves –Anchored in place by chordae tendineae (“heart strings”) –Open during heart relaxation and closed during ventricular contraction Semilunar valves –Closed during heart relaxation but open during ventricular contraction Notice these valves operate opposite of one another to force a one-way path of blood through the heart

10. Operation of the AV valves Blood returning to the atria, puts pressure against AV valves; the AV valves are forced open As the ventricles fill, AV valve flaps hang limply into ventricles Atria contract, forcing additional blood into ventricles

11. Operation of the AV valves Ventricles contract, forcing blood against AV valve flaps AV valves close Chordae tendineae tighten, preventing valve flaps from everting into atria

12. Operation of the semilunar valves As ventricles contract and intraventricular pressure rises, blood is pushed up against semilunar valves, forcing them open Semilunar valve open As ventricles relax, and intraventricular pressure falls, blood flows back from arteries, filling the leaflets of semilunar valves and forcing them to close Semilunar valve closed

13. Two Loops Systemic circulation –Blood flows from the left side of the heart through the body tissues and back to the right side of the heart Pulmonary circulation –Blood flows from the right side of the heart to the lungs and back to the left side of the heart

14. Associated Heart Vessels The Big Ones Arteries –Aorta Leaves left ventricle –Pulmonary arteries Leave right ventricle Veins –Superior and inferior venae cavae Enter right atrium –Pulmonary veins (four) Enter left atrium

15. Blood Flow Superior and inferior venae cavae carry blood to right atrium Blood travels from right atrium, through tricuspid valve, to right ventricle From right ventricle, blood passes through pulmonary semilunar valve into pulmonary trunk (leaving heart) Pulmonary trunk splits into right and left pulmonary arteries that carry blood to the lungs

16. Pulmonary Circulation At the lungs –Oxygen picked up, –carbon dioxide dropped off by blood Oxygen-rich blood returns to heart through the four pulmonary veins Blood enters –left atrium and –travels through bicuspid valve –into the left ventricle Blood leaves the left ventricle –through the aortic semilunar valve and –Into the aorta

17. Coronary Circulation Blood in the heart chambers does not nourish the myocardium The heart has its own nourishing circulatory system consisting of –Coronary arteries—branch from the aorta to supply the heart muscle with oxygenated blood –Cardiac veins—drain the myocardium of blood –Coronary sinus—a large vein on the posterior of the heart, receives blood from cardiac veins Blood empties into the right atrium via the coronary sinus

18. Coronary vessels

19. Conduction System Intrinsic conduction system (nodal system) –Heart muscle cells contract, without nerve impulses, in a regular, continuous way Special tissue sets the pace Sinoatrial node = SA node (“pacemaker”), is in the right atrium Atrioventricular node = AV node, is at the junction of the atria and ventricles Atrioventricular bundle = AV bundle (bundle of His), is in the interventricular septum Bundle branches are in the interventricular septum Purkinje fibers spread within the ventricle wall muscles

21. Heart Contractions Contraction is initiated by the sinoatrial node (SA node) Sequential stimulation occurs at other autorhythmic cells Force cardiac muscle depolarization in one direction—from atria to ventricles Once SA node starts the heartbeat –Impulse spreads to the AV node –Then the atria contract At the AV node, the impulse passes through the AV bundle, bundle branches, and Purkinje fibers Blood is ejected from the ventricles to the aorta and pulmonary trunk as the ventricles contract

22. Cardiac Conduction

23. Cardiac Cycle Atria contract simultaneously Atria relax, then ventricles contract Systole = contraction Diastole = relaxation Cardiac cycle—events of one complete heart beat –Mid-to-late diastole—blood flows from atria into ventricles –Ventricular systole—blood pressure builds before ventricle contracts, pushing out blood –Early diastole—atria finish refilling, ventricular pressure is low