Presentation is loading. Please wait.

Presentation is loading. Please wait.

Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern.

Published byTodd Augustus Hancock Modified over 8 years ago

Similar presentations

Presentation on theme: "Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern."— Presentation transcript:

1 Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern Med. 2012;156(2):105-114. doi:10.7326/0003-4819-156-2-201201170-00004 Study flow diagram.ITT = intention-to-treat. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

2 Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern Med. 2012;156(2):105-114. doi:10.7326/0003-4819-156-2-201201170-00004 Mean serum 25-(OH)D levels and COPD exacerbation rates among the on-treatment population.25-(OH)D = 25-hydroxyvitamin D; ANOVA = analysis of variance; COPD = chronic obstructive pulmonary disease; RR = rate ratio. Top. Kaplan–Meier plots of time to first exacerbation in the on-treatment population. Middle. Mean serum 25-(OH)D levels in the on-treatment population, excluding patients who started low-dose vitamin D supplementation during the trial. Bottom. COPD exacerbations per patient-year in the on-treatment population. Two-way ANOVA statistics for between-group differences in serum 25-(OH)D levels and interaction are given. For exacerbation rates, Poisson regression statistics are given. P values are unadjusted. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

3 Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern Med. 2012;156(2):105-114. doi:10.7326/0003-4819-156-2-201201170-00004 Kaplan–Meier plots of time to first exacerbation (A), time to second exacerbation (B), time to first hospitalization (C), and death from any cause (D) in the intention-to-treat population. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

4 Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern Med. 2012;156(2):105-114. doi:10.7326/0003-4819-156-2-201201170-00004 FEV 1 from baseline to end of study in the intention-to-treat population.Linear mixed-model analysis showed no significant differences between the groups and study visits (P = 0.87). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

5 Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern Med. 2012;156(2):105-114. doi:10.7326/0003-4819-156-2-201201170-00004 Mean serum 25-(OH)D levels and COPD exacerbation rates among the ITT population (A), vitamin D–naive subgroup (B), and subgroup with severe vitamin D deficiency at baseline (C).Two-way analysis-of-variance statistics for between-group differences in serum 25-(OH)D levels and Poisson regression statistics for exacerbation rates are given. P values are unadjusted. Severe vitamin D deficiency was defined as having serum 25- (OH)D levels <10 ng/mL. To convert values to nmol/L, multiply by 2.5. 25-(OH)D = 25-hydroxyvitamin D; COPD = chronic obstructive pulmonary disease; ITT = intention-to-treat; RR = rate ratio. Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

6 Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern Med. 2012;156(2):105-114. doi:10.7326/0003-4819-156-2-201201170-00004 Plasma cathelicidin levels.25-(OH)D = 25-hydroxyvitamin D; ITT = intention-to-treat. Top. Relationship between plasma cathelicidin and serum 25-(OH)D levels at baseline. Spearman r = 0.027; P = 0.04. Bottom. Plasma cathelicidin levels during the study in the ITT population. Linear mixed-model analysis showed no significant differences between the groups and study visits (P = 0.85). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

7 Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern Med. 2012;156(2):105-114. doi:10.7326/0003-4819-156-2-201201170-00004 Monocyte phagocytosis assay results.ITT = intention-to-treat. Top. Percentage of monocytes positive for phagocytosis at the end of the study in the ITT population. Bottom. Percentage of monocytes positive for phagocytosis at the end of the study in the subgroup of participants with severe vitamin D deficiency (serum 25-hydroxyvitamin D levels <10 ng/mL). Figure Legend: Copyright © American College of Physicians. All rights reserved.American College of Physicians

Download ppt "Date of download: 5/27/2016 From: High Doses of Vitamin D to Reduce Exacerbations in Chronic Obstructive Pulmonary Disease: A Randomized Trial Ann Intern."

Similar presentations

Date of download: 5/27/2016 From: Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan: A Parallel, Randomized Trial Ann Intern Med. 2013;158(9):641-649.

Date of download: 5/27/2016 From: Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan: A Parallel, Randomized Trial Ann Intern Med. 2013;158(9):
Date of download: 5/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Vitamin D and Cardiovascular Disease: Will It Live.

Date of download: 5/27/2016 Copyright © The American College of Cardiology. All rights reserved. From: Vitamin D and Cardiovascular Disease: Will It Live.
Date of download: 5/28/2016 From: High-Dose Acyclovir Compared with Short-Course Preemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Liver.

Date of download: 5/28/2016 From: High-Dose Acyclovir Compared with Short-Course Preemptive Ganciclovir Therapy To Prevent Cytomegalovirus Disease in Liver.
Date of download: 5/29/2016 From: The Effect of a Lower Target Blood Pressure on the Progression of Kidney Disease: Long-Term Follow- up of the Modification.

Date of download: 5/29/2016 From: The Effect of a Lower Target Blood Pressure on the Progression of Kidney Disease: Long-Term Follow- up of the Modification.
Date of download: 5/31/2016 From: Alendronate and Estrogen–Progestin in the Long-Term Prevention of Bone Loss: Four-Year Results from the Early Postmenopausal.

Date of download: 5/31/2016 From: Alendronate and Estrogen–Progestin in the Long-Term Prevention of Bone Loss: Four-Year Results from the Early Postmenopausal.
Date of download: 5/31/2016 From: Polymorphonuclear Leukocytes in Non-Insulin-dependent Diabetes Mellitus: Abnormalities in Metabolism and Function Ann.

Date of download: 5/31/2016 From: Polymorphonuclear Leukocytes in Non-Insulin-dependent Diabetes Mellitus: Abnormalities in Metabolism and Function Ann.
Date of download: 6/2/2016 From: Screening for Vitamin D Deficiency: A Systematic Review for the U.S. Preventive Services Task Force Ann Intern Med. 2015;162(2):109-122.

Date of download: 6/2/2016 From: Screening for Vitamin D Deficiency: A Systematic Review for the U.S. Preventive Services Task Force Ann Intern Med. 2015;162(2):
Date of download: 6/2/2016 From: Internet-Based Self-management Plus Education Compared With Usual Care in Asthma: A Randomized Trial Ann Intern Med. 2009;151(2):110-120.

Date of download: 6/2/2016 From: Internet-Based Self-management Plus Education Compared With Usual Care in Asthma: A Randomized Trial Ann Intern Med. 2009;151(2):
Date of download: 6/3/2016 From: Mortality Rates in Elderly Patients Who Take Different Angiotensin-Converting Enzyme Inhibitors after Acute Myocardial.

Date of download: 6/3/2016 From: Mortality Rates in Elderly Patients Who Take Different Angiotensin-Converting Enzyme Inhibitors after Acute Myocardial.
Date of download: 6/3/2016 From: Chest Pain Relief by Nitroglycerin Does Not Predict Active Coronary Artery Disease Ann Intern Med. 2003;139(12):979-986.

Date of download: 6/3/2016 From: Chest Pain Relief by Nitroglycerin Does Not Predict Active Coronary Artery Disease Ann Intern Med. 2003;139(12):
Date of download: 6/3/2016 From: Sex, Age, and Birth Cohort Effects in Colorectal Neoplasms: A Cohort Analysis Ann Intern Med. 2010;152(11):697-703. doi:10.7326/0003-4819-152-11-201006010-00002.

Date of download: 6/3/2016 From: Sex, Age, and Birth Cohort Effects in Colorectal Neoplasms: A Cohort Analysis Ann Intern Med. 2010;152(11): doi: /
Date of download: 6/3/2016 From: Surgery Versus Nonsurgical Treatment of Lumbar Spinal Stenosis: A Randomized Trial Ann Intern Med. 2015;162(7):465-473.

Date of download: 6/3/2016 From: Surgery Versus Nonsurgical Treatment of Lumbar Spinal Stenosis: A Randomized Trial Ann Intern Med. 2015;162(7):
Date of download: 6/3/2016 From: Elevated Plasma Homocysteine Level Is an Independent Predictor of Coronary Heart Disease Events in Patients with Type.

Date of download: 6/3/2016 From: Elevated Plasma Homocysteine Level Is an Independent Predictor of Coronary Heart Disease Events in Patients with Type.
Date of download: 6/3/2016 From: Increased Incidence of Aortic Aneurysm and Dissection in Giant Cell (Temporal) Arteritis: A Population- Based Study Ann.

Date of download: 6/3/2016 From: Increased Incidence of Aortic Aneurysm and Dissection in Giant Cell (Temporal) Arteritis: A Population- Based Study Ann.
Date of download: 6/9/2016 From: Escitalopram for the Prevention of Peginterferon-α2a–Associated Depression in Hepatitis C Virus– Infected Patients Without.

Date of download: 6/9/2016 From: Escitalopram for the Prevention of Peginterferon-α2a–Associated Depression in Hepatitis C Virus– Infected Patients Without.
Date of download: 6/18/2016 From: Treatment of Anemia in Patients With Heart Disease: A Systematic Review Ann Intern Med. 2013;159(11):746-757. doi:10.7326/0003-4819-159-11-201312030-00007.

Date of download: 6/18/2016 From: Treatment of Anemia in Patients With Heart Disease: A Systematic Review Ann Intern Med. 2013;159(11): doi: /
Date of download: 6/22/2016 From: The Efficacy of Influenza Vaccine in Elderly Persons: A Meta-Analysis and Review of the Literature Ann Intern Med. 1995;123(7):518-527.

Date of download: 6/22/2016 From: The Efficacy of Influenza Vaccine in Elderly Persons: A Meta-Analysis and Review of the Literature Ann Intern Med. 1995;123(7):
Date of download: 6/22/2016 From: Long-Term Effects of Dihydrotestosterone Treatment on Prostate Growth in Healthy, Middle-Aged Men Without Prostate Disease:

Date of download: 6/22/2016 From: Long-Term Effects of Dihydrotestosterone Treatment on Prostate Growth in Healthy, Middle-Aged Men Without Prostate Disease:
Date of download: 6/22/2016 From: Biomarkers of Inflammation and Thrombosis as Predictors of Near-Term Mortality in Patients with Peripheral Arterial Disease:

Date of download: 6/22/2016 From: Biomarkers of Inflammation and Thrombosis as Predictors of Near-Term Mortality in Patients with Peripheral Arterial Disease:
Date of download: 6/22/2016 From: Prolonged Versus Standard-Duration Venous Thromboprophylaxis in Major Orthopedic Surgery: A Systematic Review Ann Intern.

Date of download: 6/22/2016 From: Prolonged Versus Standard-Duration Venous Thromboprophylaxis in Major Orthopedic Surgery: A Systematic Review Ann Intern.

Similar presentations

Ads by Google