1. Corporate Presentation Verena Zimmermann Role of Drug Screening Technology to Improve European Road Safety

2. Objectives Briefly highlight European road safety goals and achievements Consider economic benefits of reaching road safety goals Demonstrate characteristics of leading roadside drug screening technology and its role to reduce related traffic accidents Review international roadside drug screening practices 2

3. Agenda Introduction to Securetec AG Road Accidents in the European Union Socio-Economic Impact of Road Accidents Potential Consequences of Drug Driving Case Study: Effective Technology to Reduce Drug Driving Fatalities in Australia Characteristics of Leading Roadside Drug Screening Devices Roadside Drug Screening Practice in Europe 3

4. Founded 1995 45 Employees Located near Munich, Germany Subsidiaries in the U.S. and in France Leading in the area of drug detection with worldwide sales in more than 30 countries on 5 continents In-house Research and Development Certified according to international standard ISO 9001 for quality management and the standard EN ISO 13485 for medical devices Introduction to Securetec AG 4 Detecting up to 6 Drug Substances Simultaneously

5. 5 EU Safety Action Programme (2003) to halve road fatalities by 2010 was almost fully achieved. New Target: Reduce further 50% by 2020 1 1. Towards a European road safety area, policy orientations on road safety 2011-2020, European Commission, page 4 2. DG-TREN, Technical Assistance in support of the Preparation of the European Road Safety Action Programme 2011-2020, Final Report, European Commission February 2010, page 5 Road Accidents in the European Union: EU Objectives to Reduce Fatalities ²

6. 6 DG-TREN, Technical Assistance in support of the Preparation of the European Road Safety Action Programme 2011-2020, European Commission, Final Report, February 2010, page 8 Road Fatalities per Million Inhabitants in 2006 Road Accidents in the European Union: Fatalities per Million Gap between the best and worst performing Member State is large with the best performing 4 times better than the worst

7. 7 According to Evolution of Fatalities, 2001 vs. 2008, many countries could decrease fatalities DG-TREN, Technical Assistance in support of the Preparation of the European Road Safety Action Programme 2011-2020, European Commission, Final Report, February 2010, page 9 Road Accidents in the European Union: Evolution of Fatalities

8. 8 The estimated socio-economic costs in Europe are around €180 billion comprising 2% of GDP 1 The annual motor vehicle accident costs are approximately 20 billion Euros in the UK alone² The large number of road traffic deaths and injuries represents a substantial burden for the health sector in Member States³ 1.DG-TREN, Technical Assistance in support of the Preparation of the European Road Safety Action Programme 2011-2020, European Commission, Final Report, February 2010, page i 2.Baker Tilley report for Institute of Advanced Motoring, October 4th, 2011, http://www.mansgreatestmistake.com/the-true-cost-of-cars/annual-motor-vehicle-accident-costs 3.DG-TREN, Technical Assistance in support of the Preparation of the European Road Safety Action Programme 2011-2020,, European Commission, Final Report, February 2010, page 5 Socio-Economic Impact of Road Accidents

9. 9 Example of Costs Federal Highway Research Institute (BASt), Economic Costs of Road Traffic Accidents in Germany, Presented by Dr. Thomas Kranz, DTU, Denmark, 8 - 10 June, 2011 Hospital treatment Outpatient treatment Rehabilitation Care/nursing Ambulance services Ambulatory rehabilitation Vocational rehabilitation Police operations Legal Administrative costs of insurances Job replacements Funeral expenses Duration of temporary disability Duration of hospital treatment Duration of rehabilitation Reduction of fitness for work Socio-Economic Impact of Road Accidents: Cost Segments

10. 10 One major area of traffic accident causes is recognized as:  Consumption of alcohol and drugs or fatigue... 1 Availability and reliability of blood-screening procedures and confirmation tests for measuring alcohol and drug levels are problems for most low-income and middle-income countries² Post mortem research and studies on hospitalized injured motorists are only performed in a number of countries. Epidemiological studies are available as well  Based on these studies it can however be concluded that drug driving is a major contributing factor for road accidents with injured and killed persons³ 1.SAVING 20 000 LIVES ON OUR ROADS, EUROPEAN ROAD SAFETY ACTION PROGRAMME, Halving the number of road accident victims in the European Union by 2010: A shared responsibility COMMUNICATION FROM THE COMMISSION COM(2003) 311 final, pages 6 & 7 2.WORLD REPORT ON ROAD TRAFFIC INJURY PREVENTION, World Health Organization, 2004, Page 84 3.TISPOL Strategic Drugs & Alcohol Working Group, Enforcing drug and drink driving within Europe TISPOL POLICY PAPER, October 2012, Page 6 Potential Consequences of Drug Driving

11. 11 The use of illicit drugs and some medicines, is an increasingly worrying factor in road accidents… If nothing is done urgently, there could soon be more accidents due to drugs than to alcohol. Different measures will have to be taken e.g.: o Establishment of a harmonised procedure to detect illicit drugs in drivers o Development of detection equipment… SAVING 20 000 LIVES ON OUR ROADS, EUROPEAN ROAD SAFETY ACTION PROGRAMME, Halving the number of road accident victims in the European Union by 2010: A shared responsibility COMMUNICATION FROM THE COMMISSION COM(2003) 311 final, pages 20 & 21 Potential Consequences of Drug Driving

12. Case Study: Effective Technology to Reduce Drug Driving Fatalities in Australia Campaign: “Drivers tested: anybody, anywhere, anytime” reduced percentage of drug drivers involved in fatal accidents by half 12 2003 - 31% of drivers involved in fatal accidents tested positively for drugs 2004 - the Australian federal state of Victoria was the first region worldwide to establish a legal basis for drug control of vehicle operators which is not dependent on cause for suspicion  The entire street is blocked and all drivers are tested for alcohol and drugs  For Drug Screening, Securetec’s DrugWipe ® is applied 2005 - 25% of the drivers who were involved in severe traffic accidents, tested positively for illegal drugs 2009 – Only 15% www.police.vic.gov.au/policelife & www.tacsafety.com.au/campaigns/drug-driving 5th Australasian Drug Strategy Conference, Melbourne, Victoria in March 2010

13. 13 Results in 3 to 8 minutes Very high sensitivity, specificity and accuracy Simple, fast and hygienic sampling (saliva) Very small saliva sample (e.g. obtainable in seconds, not minutes) Clear visible test lines Small, portable, robust, and versatile products (e.g. saliva, sweat, surfaces) No electronics necessary: Handheld electronic reading devices can be used as an option Characteristics of Leading Roadside Drug Screening Devices

14. Germany 1998 Switzerland 2005 Iceland 2006 Finland 2004 Poland 2006 Czech Republic 2006 Belgium 2010 France 2008 Norway 2011 Slovak Republic 2009 Luxembourg 2011 Italy 2011 14 Roadside Drug Screening Practice in Europe Overview not comprehensive

15. 15 Why Test Oral Fluid? Saliva collection is much less invasive than urine collection When test person is not controlled during urine collection, sample can be manipulated and falsified Saliva sample reveals recent drug use Roadside Drug Screening Practice in Europe: Rationale for Saliva Sampling Comparison of detectable THC traces in blood, saliva, urine after consumption Most often, legislation in Europe dictates: Saliva is tested at the roadside, blood for confirmation

16. 16 http://www.druid-project.eu Roadside Drug Screening Practice in Europe: DRUID Study Sponsored by the European Commission, police officers evaluated failure rate, operability hygiene and technical performance of the most common oral fluid rapid tests - 36 institutions from 18 countries participated The study took place from 2006 – 2009 All data were independently gathered and assessed by Police and Universities in the EU and are publicly available The DRUID Study was defined in two parts:  Part I: ESTHER – Evaluation of Easy Operation  Part II: DRUID – Scientific Evaluation of Reliability ESTHER (Evaluation of oral Fluid Drug Screening devices by TISPOL to Harmonise European police Requirements DRUID (Driving under the Influence of Drugs)

17. 17 Part I “ESTHER” on Practicability (2006 – 2009) Roadside Drug Screening Practice in Europe: ESTHER Study Highlights

18. Solutions based on electronic readers 18 Part II “DRUID” Scientific Evaluation (2008 – 2009) Druid Project Deliverable 3.2.1 from 8.12.2009 National Institute for Health and Welfare, Finland. Roadside Drug Screening Practice in Europe: DRUID Study Highlights (Accuracy = 93%)

19. First roadside trials in 1998 First sales in 1999 Used in 10 out of 16 German States In 2011, over 60,000 DrugWipes were employed 19 Germany Traffic legislation changed in 2005 DrugWipe ® 5 introduced countrywide in 2005 ~20,000 pieces are used annually Switzerland Roadside Drug Screening Practice in Europe: Cooperation

20. Various saliva tests evaluated in ROSITA II DrugWipe ® 6 S (including Benzodiazepines) introduced in 2005 ~19,000 DrugWipe ® 6 S Annually 20 Finland In 2011, the respected Institut National de Criminalistique et de Criminologie (INCC) in Brussels, Belgium confirmed that DrugWipe ® 5+ is the best screening device for traffic controls Belgium police followed the recommendation and are now using DrugWipe ® nationwide. Belgium Roadside Drug Screening Practice in Europe: Cooperation

21. 21 In a comparative study in 2011, the best saliva tests available on the market were tested intensively over a period of 6 months: DrugWipe ® performance in laboratory and field tests was convincing. The legally required detection limits in France could be achieved and detection at these standards proved to be repeatable and reliable. DrugWipe ® 5 S safely detects at least 15 ng/ml  9-THC in saliva DrugWipe ® 5 S won the tender as the best drug screening device 110,000 drug tests per year delivered to the Police, Gendarmerie and Military Services France Roadside Drug Screening Practice in Europe: Cooperation

22. 22 EU member states and institutions widely recognize that drug driving significantly contributes to traffic accidents Several EU member states have already launched roadside drug screening programs which aim to reduce traffic accidents Technology can enable drug screening: There are devices available which are very easy-to-use and highly reliable Cooperation between industry and traffic police can only be achieved via national political will and relevant legislation Take Home Messages

23. Thank you Securetec Detektions-Systeme AG Lilienthalstr. 7 D-85579 Neubiberg (near Munich) Germany www.securetec.net 23