1. Date of download: 5/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease JAMA. 1999;281(15):1401-1406. doi:10.1001/jama.281.15.1401 For cohort, r=0.58 and P<.001.Regression line depicts correlation for entire cohort. Figure Legend:

2. Date of download: 5/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease JAMA. 1999;281(15):1401-1406. doi:10.1001/jama.281.15.1401 For cohort, r=0.43 andP<.001. Figure Legend:

3. Date of download: 5/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease JAMA. 1999;281(15):1401-1406. doi:10.1001/jama.281.15.1401 For cohort, r=0.59 andP<.001. Figure Legend:

4. Date of download: 5/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease JAMA. 1999;281(15):1401-1406. doi:10.1001/jama.281.15.1401 Relative to the group without dementia (Clinical Dementia Rating[CDR] Scale score=0.0), the activity ofacetylcholinesterase (AChE) was significantly reduced(P<.001 for all) in the CDR 5.0 group only. BA indicatesBrodmann area. Figure Legend:

5. Date of download: 5/27/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Cholinergic Markers in Elderly Patients With Early Signs of Alzheimer Disease JAMA. 1999;281(15):1401-1406. doi:10.1001/jama.281.15.1401 Relative to the group without dementia (Clinical Dementia Rating[CDR] Scale score=0.0), the activity of cholineacetyltransferase (ChAT) was significantly reduced (P<.001for all) in the CDR 5.0 group only. BA indicates Brodmann area. Figure Legend: